[{"data":1,"prerenderedAt":232},["ShallowReactive",2],{"drug-amphetamine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":62,"contraindications":114,"warnings":124,"renal":139,"monitoring":148,"interactions":149,"review":150,"examples":153,"atc":168,"iran":170,"links":177,"populations":192,"usApproval":227},"amphetamine",1,{"fa":7,"en":8},"آمفتامین (نمک‌های ترکیبی، آهسته‌رهش)","Mixed amphetamine salts (extended-release)","nervous-system",{"fa":11,"en":12},"محرک CNS","CNS stimulant",[14],{"name":15,"market":16},"Adderall XR","US",[18,19,20,21,22],"adderall","آدرال","dextroamphetamine","دکستروآمفتامین","آمفتامین",[24,38,46,54],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"xr-10","capsule","oral","10 mg XR capsule",{"amount":30,"unit":31,"perUnit":26,"scored":32},10,"mg",false,[16],[35],{"source":36,"section":37},"fda-adderall-xr","3",{"id":39,"form":26,"route":27,"label":40,"concentration":41,"markets":43,"refs":44},"xr-20","20 mg XR capsule",{"amount":42,"unit":31,"perUnit":26,"scored":32},20,[16],[45],{"source":36,"section":37},{"id":47,"form":26,"route":27,"label":48,"concentration":49,"markets":51,"refs":52},"xr-5","5 mg XR capsule",{"amount":50,"unit":31,"perUnit":26,"scored":32},5,[16],[53],{"source":36,"section":37},{"id":55,"form":26,"route":27,"label":56,"concentration":57,"markets":59,"refs":60},"xr-30","30 mg XR capsule",{"amount":58,"unit":31,"perUnit":26,"scored":32},30,[16],[61],{"source":36,"section":37},[63,90,103],{"id":64,"disease":65,"label":66,"population":69,"type":75,"unit":31,"dose":76,"refs":77,"notes":80},"c6","adhd",{"fa":67,"en":68},"ADHD کودک ۶ تا ۱۲ سال — ۱۰ mg صبح؛ هفتگی ۵ یا ۱۰ mg افزایش تا حداکثر ۳۰ mg","ADHD, children 6–12 y — 10 mg in the morning; +5 or 10 mg weekly to max 30 mg",{"minAge":70,"maxAge":73},{"value":71,"unit":72},6,"year",{"value":74,"unit":72},13,"fixed",{"perDose":30,"perDoseMax":58,"dosesPerDay":5},[78],{"source":36,"section":79},"2.3",[81],{"text":82,"refs":85},{"fa":83,"en":84},"پیش از شروع بیماری قلبی و تیک بررسی شود. کپسول کامل یا محتوا روی پوره سیب.","Screen for cardiac disease and tics first. Swallow whole or sprinkle on applesauce.",[86,88],{"source":36,"section":87},"2.1",{"source":36,"section":89},"2.2",{"id":91,"disease":65,"label":92,"population":95,"type":75,"unit":31,"dose":99,"refs":100},"c13",{"fa":93,"en":94},"ADHD نوجوان ۱۳ تا ۱۷ سال — ۱۰ mg؛ پس از یک هفته تا ۲۰ mg","ADHD, adolescents 13–17 y — 10 mg; may increase to 20 mg after one week",{"minAge":96,"maxAge":97},{"value":74,"unit":72},{"value":98,"unit":72},18,{"perDose":30,"perDoseMax":42,"dosesPerDay":5},[101],{"source":36,"section":102},"2.4",{"id":104,"disease":65,"label":105,"population":108,"type":75,"unit":31,"dose":110,"refs":111},"adult",{"fa":106,"en":107},"ADHD بزرگسال — ۲۰ mg صبح","ADHD, adults — 20 mg in the morning",{"minAge":109},{"value":98,"unit":72},{"perDose":42,"dosesPerDay":5},[112],{"source":36,"section":113},"2.5",[115],{"id":116,"severity":117,"text":118,"refs":121},"ci","block",{"fa":119,"en":120},"حساسیت به آمفتامین؛ MAOI همزمان یا ظرف ۱۴ روز (بحران فشار خون).","Hypersensitivity to amphetamine; MAOIs concomitantly or within 14 days (hypertensive crisis).",[122],{"source":36,"section":123},"4",[125,132],{"text":126,"refs":129},{"fa":127,"en":128},"هشدار جعبه‌ای: پتانسیل بالای سوءمصرف، اعتیاد، بیش‌مصرفی و مرگ.","Boxed warning: high potential for abuse, misuse and addiction, overdose and death.",[130],{"source":36,"section":131},"Boxed Warning",{"text":133,"refs":136},{"fa":134,"en":135},"خطر در بیماری قلبی جدی؛ افزایش فشار و ضربان؛ عوارض روانی؛ مهار رشد؛ تشنج؛ رینود؛ سندرم سروتونین؛ تیک.","Risk in serious cardiac disease; raised BP and HR; psychiatric reactions; growth suppression; seizures; Raynaud; serotonin syndrome; tics.",[137],{"source":36,"section":138},"5",[140],{"egfrBelow":58,"severity":141,"text":142,"refs":145},"warn",{"fa":143,"en":144},"GFR ۱۵ تا \u003C۳۰: بزرگسال ۱۵ mg، کودک ۵ mg (۶ تا ۱۲ سال حداکثر ۲۰)؛ ESRD توصیه نمی‌شود.","GFR 15–\u003C30: adults 15 mg, children 5 mg (6–12 y max 20); ESRD not recommended.",[146],{"source":36,"section":147},"2.6",[],[],{"status":151,"reviewer":152,"date":152},"unverified",null,[154,159,164],{"regimen":64,"formulation":25,"input":155,"expect":158},{"ageYears":156,"weightKg":157},8,25,{"perDose":30,"tabletsPerDoseRounded":5,"upperPerDose":58},{"regimen":91,"formulation":25,"input":160,"expect":163},{"ageYears":161,"weightKg":162},14,50,{"perDose":30,"tabletsPerDoseRounded":5,"upperPerDose":42},{"regimen":104,"formulation":39,"input":165,"expect":167},{"ageYears":58,"weightKg":166},70,{"perDose":42,"tabletsPerDoseRounded":5},[169],"N06BA01",{"status":171,"refs":172},"not-found",[173],{"source":174,"section":175,"url":176},"darooyab-generic","G-3363\u002FAmfetamine","https:\u002F\u002Fwww.darooyab.ir\u002FG-3363\u002FAmfetamine",[178,182,186,189],{"kind":179,"url":180,"label":181},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021303","NDA021303",{"kind":183,"url":184,"label":185},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=aff45863-ffe1-4d4f-8acf-c7081512a6c0","FDA Adderall XR",{"kind":187,"url":188,"label":169},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06BA01",{"kind":190,"url":176,"label":191},"darooyab","Amfetamine",{"pregnancy":193,"lactation":202,"pediatric":211,"geriatric":219},{"level":194,"text":195,"quote":198,"refs":199},"caution",{"fa":196,"en":197},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from published epidemiologic studies and postmarketing reports on use of prescription amphetamine in pregnant women have not identified a drug-associated risk of major birth defects and miscarriage (see Data ) .",[200],{"source":36,"section":201},"8.1",{"level":203,"text":204,"quote":207,"refs":208},"avoid",{"fa":205,"en":206},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in nursing infants, advise patients that breastfeeding is not recommended during treatment with ADDERALL XR.",[209],{"source":36,"section":210},"8.2",{"level":194,"text":212,"quote":215,"refs":216},{"fa":213,"en":214},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of ADDERALL XR have been established in pediatric patients with ADHD 6 years of age and older.",[217],{"source":36,"section":218},"8.4",{"level":194,"text":220,"quote":223,"refs":224},{"fa":221,"en":222},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","ADDERALL XR has not been studied in the geriatric population.",[225],{"source":36,"section":226},"8.5",{"kind":228,"refs":229,"id":181},"NDA",[230],{"source":36,"section":231},"SPL approval \u002F marketing category",1792444714798]