[{"data":1,"prerenderedAt":211},["ShallowReactive",2],{"drug-atorvastatin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":59,"contraindications":98,"warnings":108,"renal":109,"monitoring":110,"interactions":111,"review":112,"examples":115,"atc":125,"iran":127,"links":155,"populations":172,"usApproval":206},"atorvastatin",1,{"fa":7,"en":8},"آتورواستاتین","Atorvastatin","cardiovascular",{"fa":11,"en":12},"استاتین (مهارکننده HMG-CoA ردوکتاز)","Statin",[14],{"name":15,"market":16},"Lipitor","US",[18,7,19],"lipitor","استاتین",[21,35,43,51],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-10","tablet","oral","10 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},10,"mg",false,[16],[32],{"source":33,"section":34},"fda-atorvastatin","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-20","20 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},20,[16],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":48,"refs":49},"tab-40","40 mg tablet",{"amount":47,"unit":28,"perUnit":23,"scored":29},40,[16],[50],{"source":33,"section":34},{"id":52,"form":23,"route":24,"label":53,"concentration":54,"markets":56,"refs":57},"tab-80","80 mg tablet",{"amount":55,"unit":28,"perUnit":23,"scored":29},80,[16],[58],{"source":33,"section":34},[60,78],{"id":61,"disease":62,"label":63,"population":66,"type":71,"unit":28,"dose":72,"refs":73},"hefh-child","hyperlipidemia",{"fa":64,"en":65},"هیپرکلسترولمی خانوادگی هتروزیگوت — ۱۰ سال به بالا: ۱۰ تا ۲۰ mg روزانه","HeFH — ≥10 years: 10–20 mg daily",{"minAge":67,"maxAge":69},{"value":27,"unit":68},"year",{"value":70,"unit":68},18,"fixed",{"perDose":27,"perDoseMax":39,"dosesPerDay":5},[74,76],{"source":33,"section":75},"2.3",{"source":33,"section":77},"8.4",{"id":79,"disease":62,"label":80,"population":83,"type":71,"unit":28,"dose":85,"refs":86,"notes":89},"adult",{"fa":81,"en":82},"بزرگسال — شروع ۱۰ تا ۲۰ mg روزانه (محدوده ۱۰ تا ۸۰)","Adults — start 10–20 mg daily (range 10–80)",{"minAge":84},{"value":70,"unit":68},{"perDose":27,"perDoseMax":55,"dosesPerDay":5},[87],{"source":33,"section":88},"2.2",[90],{"text":91,"refs":94},{"fa":92,"en":93},"اگر کاهش LDL بیش از ۴۵٪ لازم است، شروع با ۴۰ mg. LDL را از ۴ هفته بعد بسنجید.","If >45% LDL-C reduction needed, may start at 40 mg. Assess LDL-C from 4 weeks.",[95,96],{"source":33,"section":88},{"source":33,"section":97},"2.1",[99],{"id":100,"severity":101,"text":102,"refs":105},"liver","block",{"fa":103,"en":104},"نارسایی حاد کبد یا سیروز جبران‌نشده؛ حساسیت.","Acute liver failure or decompensated cirrhosis; hypersensitivity.",[106],{"source":33,"section":107},"4",[],[],[],[],{"status":113,"reviewer":114,"date":114},"unverified",null,[116,121],{"regimen":61,"formulation":22,"input":117,"expect":120},{"ageYears":118,"weightKg":119},12,45,{"perDose":27,"upperPerDose":39},{"regimen":79,"formulation":22,"input":122,"expect":124},{"ageYears":123,"weightKg":55},50,{"perDose":27,"tabletsPerDoseRounded":5},[126],"C10AA05",{"status":128,"forms":129,"refs":150},"registered",[130,134,138,142,146],{"code":131,"en":132,"fa":133},"01910","ATORVASTATIN 10MG TAB","قرص آتورواستاتین ۱۰ میلی‌گرم",{"code":135,"en":136,"fa":137},"01911","ATORVASTATIN 20MG TAB","قرص آتورواستاتین ۲۰ میلی‌گرم",{"code":139,"en":140,"fa":141},"01912","ATORVASTATIN 40MG TAB","قرص آتورواستاتین ۴۰ میلی‌گرم",{"code":143,"en":144,"fa":145},"16350","ATORVASTATIN 80MG TAB","قرص آتورواستاتین ۸۰ میلی‌گرم",{"code":147,"en":148,"fa":149},"52871","ATORVASTATIN (AS CALCIUM) TABLET ORAL 80 mg","قرص آتورواستاتین (معادل کلسیم) ۸۰ میلی‌گرم",[151],{"source":152,"section":153,"url":154},"darooyab-generic","G-1537\u002FAtorvastatin","https:\u002F\u002Fwww.darooyab.ir\u002FG-1537\u002FAtorvastatin",[156,160,164,167,170],{"kind":157,"url":158,"label":159},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=205519","ANDA205519",{"kind":161,"url":162,"label":163},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=10e766cc-c3fd-4584-a0d7-652c516e828c","FDA Atorvastatin",{"kind":165,"url":166,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa600045.html",{"kind":168,"url":169,"label":126},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C10AA05",{"kind":171,"url":154,"label":8},"darooyab",{"pregnancy":173,"lactation":182,"pediatric":190,"geriatric":198},{"level":174,"text":175,"quote":178,"refs":179},"avoid",{"fa":176,"en":177},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Atorvastatin calcium decreases synthesis of cholesterol and possibly other biologically active substances derived from cholesterol; therefore, atorvastatin calcium may cause fetal harm when administered to pregnant patients based on the mechanism of action [see Clinical Pharmacology (12.1) ].",[180],{"source":33,"section":181},"8.1",{"level":174,"text":183,"quote":186,"refs":187},{"fa":184,"en":185},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in a breastfed infant, based on the mechanism of action, advise patients that breastfeeding is not recommended during treatment with atorvastatin calcium [see Use in Specific Populations (8.1) , Clinical Pharmacology (12.1) ] .",[188],{"source":33,"section":189},"8.2",{"level":191,"text":192,"quote":195,"refs":196},"caution",{"fa":193,"en":194},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of atorvastatin calcium as an adjunct to diet to reduce LDL-C have been established pediatric patients 10 years of age and older with HeFH.",[197],{"source":33,"section":77},{"level":191,"text":199,"quote":202,"refs":203},{"fa":200,"en":201},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Dose selection for an elderly patient should be cautious, recognizing the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy and the higher risk of myopathy.",[204],{"source":33,"section":205},"8.5",{"kind":207,"refs":208,"id":159},"ANDA",[209],{"source":33,"section":210},"SPL approval \u002F marketing category",1792440728188]