[{"data":1,"prerenderedAt":204},["ShallowReactive",2],{"drug-bisoprolol":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":20,"formulations":25,"regimens":57,"contraindications":99,"warnings":109,"renal":110,"monitoring":111,"interactions":112,"review":113,"examples":116,"atc":122,"iran":124,"links":148,"populations":165,"usApproval":199},"bisoprolol",1,{"fa":7,"en":8},"بیزوپرولول","Bisoprolol","cardiovascular",{"fa":11,"en":12},"بتابلاکر انتخابی β1","Beta-1 selective blocker",[14,17],{"name":15,"market":16},"Zebeta","US",{"name":18,"market":19},"Concor","GB",[21,22,23,24,7],"zebeta","concor","کنکور","بیسوپرولول",[26,40,49],{"id":27,"form":28,"route":29,"label":30,"concentration":31,"markets":35,"refs":36},"tab-2-5","tablet","oral","2.5 mg tablet",{"amount":32,"unit":33,"perUnit":28,"scored":34},2.5,"mg",false,[16],[37],{"source":38,"section":39},"fda-bisoprolol","How Supplied",{"id":41,"form":28,"route":29,"label":42,"concentration":43,"markets":46,"refs":47},"tab-5","5 mg tablet (scored)",{"amount":44,"unit":33,"perUnit":28,"scored":45},5,true,[16],[48],{"source":38,"section":39},{"id":50,"form":28,"route":29,"label":51,"concentration":52,"markets":54,"refs":55},"tab-10","10 mg tablet",{"amount":53,"unit":33,"perUnit":28,"scored":34},10,[16],[56],{"source":38,"section":39},[58,84],{"id":59,"disease":60,"label":61,"population":64,"type":68,"unit":33,"dose":69,"refs":70,"limits":73,"notes":77},"htn","hypertension",{"fa":62,"en":63},"فشار خون — ۵ mg یک بار در روز","Hypertension — 5 mg once daily",{"minAge":65},{"value":66,"unit":67},18,"year","fixed",{"perDose":44,"dosesPerDay":5},[71],{"source":38,"section":72},"Dosage and Administration",{"maxPerDay":74,"refs":75},20,[76],{"source":38,"section":72},[78],{"text":79,"refs":82},{"fa":80,"en":81},"گاهی شروع ۲٫۵ mg (برونکواسپاسم). افزایش به ۱۰ و سپس ۲۰ mg. نارسایی کبد یا CrCl کمتر از ۴۰: شروع ۲٫۵ mg.","Some patients start 2.5 mg (bronchospasm). Increase to 10 then 20 mg. Hepatic impairment or CrCl \u003C40: start 2.5 mg.",[83],{"source":38,"section":72},{"id":85,"disease":60,"label":86,"population":89,"type":91,"unit":33,"dose":92,"refs":96},"peds",{"fa":87,"en":88},"زیر ۱۸ سال","Under 18 years",{"maxAge":90},{"value":66,"unit":67},"notCalculated",{"reason":93},{"fa":94,"en":95},"بی‌خطری و اثربخشی در کودکان ثابت نشده است.","Safety and effectiveness in children not established.",[97],{"source":38,"section":98},"Pediatric Use",[100],{"id":101,"severity":102,"text":103,"refs":106},"ci","block",{"fa":104,"en":105},"شوک کاردیوژنیک، نارسایی قلبی آشکار، بلوک AV درجه ۲ یا ۳، برادی‌کاردی سینوسی شدید.","Cardiogenic shock, overt cardiac failure, second- or third-degree AV block, marked sinus bradycardia.",[107],{"source":38,"section":108},"Contraindications",[],[],[],[],{"status":114,"reviewer":115,"date":115},"unverified",null,[117],{"regimen":59,"formulation":41,"input":118,"expect":121},{"ageYears":119,"weightKg":120},50,80,{"perDose":44},[123],"C07AB07",{"status":125,"forms":126,"refs":143},"registered",[127,131,135,139],{"code":128,"en":129,"fa":130},"10100","BISOPROLOL FUMARATE 1.25MG TAB","قرص بیزوپرولول فومارات ۱٫۲۵ میلی‌گرم",{"code":132,"en":133,"fa":134},"08904","BISOPROLOL FUMARATE 10MG TAB","قرص بیزوپرولول فومارات ۱۰ میلی‌گرم",{"code":136,"en":137,"fa":138},"11472","BISOPROLOL FUMARATE 2.5MG TAB","قرص بیزوپرولول فومارات ۲٫۵ میلی‌گرم",{"code":140,"en":141,"fa":142},"07125","BISOPROLOL FUMARATE 5MG TAB","قرص بیزوپرولول فومارات ۵ میلی‌گرم",[144],{"source":145,"section":146,"url":147},"darooyab-generic","G-1560\u002FBisoprolol","https:\u002F\u002Fwww.darooyab.ir\u002FG-1560\u002FBisoprolol",[149,153,157,160,163],{"kind":150,"url":151,"label":152},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=075643","ANDA075643",{"kind":154,"url":155,"label":156},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=83e4b4e5-9130-44c8-abab-fcd0db5d8c49","FDA Bisoprolol",{"kind":158,"url":159,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa693024.html",{"kind":161,"url":162,"label":123},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C07AB07",{"kind":164,"url":147,"label":8},"darooyab",{"lactation":166,"pediatric":175,"geriatric":183,"pregnancy":191},{"level":167,"text":168,"quote":171,"refs":172},"caution",{"fa":169,"en":170},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk caution should be exercised when bisoprolol fumarate is administered to nursing women.",[173],{"source":38,"section":174},"Nursing Mothers",{"level":176,"text":177,"quote":180,"refs":181},"not-established",{"fa":178,"en":179},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[182],{"source":38,"section":98},{"level":167,"text":184,"quote":187,"refs":188},{"fa":185,"en":186},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Observed reductions in heart rate were slightly greater in the elderly than in the young and tended to increase with increasing dose.",[189],{"source":38,"section":190},"Geriatric Use",{"level":167,"quote":192,"text":193,"refs":196},"مصرف در بارداری بیزوپرولول گروه C در شرايط خاص و نظارت ويژه پزشك قابل استفاده است:",{"fa":194,"en":195},"دارویاب: گروه C — فقط اگر فایده بیشتر از خطر باشد.","Darooyab: category C — only if benefit outweighs risk.",[197],{"source":145,"section":198,"url":147},"G-1560\u002FBisoprolol — مصرف در بارداری",{"kind":200,"refs":201,"id":152},"ANDA",[202],{"source":38,"section":203},"SPL approval \u002F marketing category",1792440727822]