[{"data":1,"prerenderedAt":201},["ShallowReactive",2],{"drug-captopril":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":60,"contraindications":105,"warnings":124,"renal":125,"monitoring":126,"interactions":127,"review":128,"examples":131,"atc":136,"iran":138,"links":154,"populations":171,"usApproval":196},"captopril",1,{"fa":7,"en":8},"کاپتوپریل","Captopril","cardiovascular",{"fa":11,"en":12},"مهارکننده ACE","ACE inhibitor",[14],{"name":15,"market":16},"Capoten","US",[18,19,7,20],"capoten","کاپوتن","ACEI",[22,36,44,52],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-12-5","tablet","oral","12.5 mg tablet (scored)",{"amount":28,"unit":29,"perUnit":24,"scored":30},12.5,"mg",true,[16],[33],{"source":34,"section":35},"fda-captopril","How Supplied",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-25","25 mg tablet (scored)",{"amount":40,"unit":29,"perUnit":24,"scored":30},25,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-50","50 mg tablet (scored)",{"amount":48,"unit":29,"perUnit":24,"scored":30},50,[16],[51],{"source":34,"section":35},{"id":53,"form":24,"route":25,"label":54,"concentration":55,"markets":57,"refs":58},"tab-100","100 mg tablet (scored)",{"amount":56,"unit":29,"perUnit":24,"scored":30},100,[16],[59],{"source":34,"section":35},[61,90],{"id":62,"disease":63,"label":64,"population":67,"type":71,"unit":29,"dose":72,"refs":74,"limits":77,"notes":81},"adult-htn","hypertension",{"fa":65,"en":66},"فشار خون — بزرگسال: شروع ۲۵ mg دو یا سه بار در روز","Hypertension — adults: start 25 mg two or three times daily",{"minAge":68},{"value":69,"unit":70},18,"year","fixed",{"perDose":40,"dosesPerDay":73},2,[75],{"source":34,"section":76},"Dosage and Administration, Hypertension",{"maxPerDay":78,"refs":79},450,[80],{"source":34,"section":76},[82],{"text":83,"refs":86},{"fa":84,"en":85},"یک ساعت قبل از غذا. پس از ۱ تا ۲ هفته تا ۵۰ mg دو یا سه بار؛ معمولاً بیش از ۵۰ mg سه بار لازم نیست؛ محدوده ۲۵ تا ۱۵۰ mg دو یا سه بار؛ حداکثر ۴۵۰ mg\u002Fday.","One hour before meals. After 1–2 weeks up to 50 mg two or three times daily; usually not above 50 mg three times daily; range 25–150 mg two or three times daily; max 450 mg\u002Fday.",[87,88],{"source":34,"section":76},{"source":34,"section":89},"Dosage and Administration",{"id":91,"disease":63,"label":92,"population":95,"type":97,"unit":29,"dose":98,"refs":102},"peds",{"fa":93,"en":94},"کودکان","Children",{"maxAge":96},{"value":69,"unit":70},"notCalculated",{"reason":99},{"fa":100,"en":101},"بی‌خطری و اثربخشی در کودکان ثابت نشده؛ فقط اگر سایر روش‌ها مؤثر نبوده.","Safety and effectiveness in children not established; use only if other measures failed.",[103],{"source":34,"section":104},"Pediatric Use",[106,115],{"id":107,"severity":108,"text":109,"refs":112},"angioedema","block",{"fa":110,"en":111},"سابقه آنژیوادم (با ACEI، ارثی یا ایدیوپاتیک)؛ همراه ساکوبیتریل (۳۶ ساعت فاصله)؛ آلیسکیرن در دیابت؛ حساسیت.","History of angioedema (ACE inhibitor, hereditary or idiopathic); with sacubitril (36 h gap); aliskiren in diabetes; hypersensitivity.",[113],{"source":34,"section":114},"Contraindications",{"id":116,"severity":117,"text":118,"refs":121},"pregnancy","warn",{"fa":119,"en":120},"هشدار جعبه‌ای: سمیت جنینی — با تشخیص بارداری فوراً قطع شود.","Boxed warning: fetal toxicity — stop as soon as pregnancy is detected.",[122],{"source":34,"section":123},"Boxed Warning",[],[],[],[],{"status":129,"reviewer":130,"date":130},"unverified",null,[132],{"regimen":62,"formulation":37,"input":133,"expect":135},{"ageYears":48,"weightKg":134},80,{"perDose":40,"perDay":48,"tabletsPerDoseRounded":5},[137],"C09AA01",{"status":139,"forms":140,"refs":149},"registered",[141,145],{"code":142,"en":143,"fa":144},"00205","CAPTOPRIL 25MG TAB","قرص کاپتوپریل ۲۵ میلی‌گرم",{"code":146,"en":147,"fa":148},"00206","CAPTOPRIL 50MG TAB","قرص کاپتوپریل ۵۰ میلی‌گرم",[150],{"source":151,"section":152,"url":153},"darooyab-generic","G-1581\u002FCaptopril","https:\u002F\u002Fwww.darooyab.ir\u002FG-1581\u002FCaptopril",[155,159,163,166,169],{"kind":156,"url":157,"label":158},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=074677","ANDA074677",{"kind":160,"url":161,"label":162},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=1395ba5b-2fc9-41ff-9c43-e0740d781dee","FDA Captopril",{"kind":164,"url":165,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682823.html",{"kind":167,"url":168,"label":137},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C09AA01",{"kind":170,"url":153,"label":8},"darooyab",{"pregnancy":172,"lactation":180,"pediatric":188},{"level":173,"text":174,"quote":177,"refs":178},"avoid",{"fa":175,"en":176},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","See WARNINGS: Fetal Toxicity",[179],{"source":34,"section":123},{"level":173,"text":181,"quote":184,"refs":185},{"fa":182,"en":183},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in nursing infants from captopril, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of captopril tablets to the mother (see PRECAUTIONS: Pediatric Use ).",[186],{"source":34,"section":187},"Nursing Mothers",{"level":189,"text":190,"quote":193,"refs":194},"not-established",{"fa":191,"en":192},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[195],{"source":34,"section":104},{"kind":197,"refs":198,"id":158},"ANDA",[199],{"source":34,"section":200},"SPL approval \u002F marketing category",1792191870077]