[{"data":1,"prerenderedAt":285},["ShallowReactive",2],{"drug-carbamazepine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":46,"contraindications":140,"warnings":150,"renal":158,"monitoring":159,"interactions":160,"review":161,"examples":164,"atc":187,"iran":189,"links":225,"populations":245,"usApproval":280},"carbamazepine",1,{"fa":7,"en":8},"کاربامازپین","Carbamazepine","nervous-system",{"fa":11,"en":12},"ضدتشنج","Anticonvulsant",[14],{"name":15,"market":16},"Tegretol","US",[18,19,7],"tegretol","تگرتول",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-200","tablet","oral","200 mg tablet (partially scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},200,"mg",true,[16],[32],{"source":33,"section":34},"fda-carbamazepine","How Supplied",{"id":36,"form":37,"route":24,"label":38,"concentration":39,"markets":42,"refs":43},"susp-100-5","suspension","100 mg \u002F 5 mL suspension",{"amount":40,"unit":28,"perVolumeMl":41},100,5,[16],[44],{"source":45,"section":34},"fda-carbamazepinesusp",[47,76,96,113],{"id":48,"disease":49,"label":50,"population":53,"type":57,"unit":28,"dose":58,"refs":62,"limits":65,"notes":69},"epi-lt6","epilepsy",{"fa":51,"en":52},"صرع — زیر ۶ سال: شروع ۱۰ تا ۲۰ mg\u002Fkg\u002Fday","Epilepsy — under 6 y: start 10–20 mg\u002Fkg\u002Fday",{"maxAge":54},{"value":55,"unit":56},6,"year","weightBased",{"perKgPerDay":59,"perKgPerDayMax":60,"dividedDoses":61},10,20,2,[63],{"source":33,"section":64},"Dosage and Administration",{"maxPerKgPerDay":66,"refs":67},35,[68],{"source":33,"section":64},[70],{"text":71,"refs":74},{"fa":72,"en":73},"هفتگی تا پاسخ مطلوب افزایش؛ معمولاً پاسخ زیر ۳۵ mg\u002Fkg\u002Fday؛ قرص دو یا سه بار در روز.","Increase weekly to response; usually below 35 mg\u002Fkg\u002Fday; tablets 2–3 times daily.",[75],{"source":33,"section":64},{"id":77,"disease":49,"label":78,"population":81,"type":85,"unit":28,"dose":86,"refs":87,"notes":89},"epi-6-12",{"fa":79,"en":80},"صرع — ۶ تا ۱۲ سال: شروع ۱۰۰ mg دو بار در روز","Epilepsy — 6–12 y: start 100 mg twice daily",{"minAge":82,"maxAge":83},{"value":55,"unit":56},{"value":84,"unit":56},13,"fixed",{"perDose":40,"dosesPerDay":61},[88],{"source":33,"section":64},[90],{"text":91,"refs":94},{"fa":92,"en":93},"افزایش هفتگی تا ۱۰۰ mg\u002Fday.","Increase weekly by up to 100 mg\u002Fday.",[95],{"source":33,"section":64},{"id":97,"disease":49,"label":98,"population":101,"type":85,"unit":28,"dose":103,"refs":104,"notes":106},"epi-12plus",{"fa":99,"en":100},"صرع — بزرگسال و بالای ۱۲ سال: شروع ۲۰۰ mg دو بار در روز","Epilepsy — adults and >12 y: start 200 mg twice daily",{"minAge":102},{"value":84,"unit":56},{"perDose":27,"dosesPerDay":61},[105],{"source":33,"section":64},[107],{"text":108,"refs":111},{"fa":109,"en":110},"افزایش هفتگی تا ۲۰۰ mg\u002Fday.","Increase weekly by up to 200 mg\u002Fday.",[112],{"source":33,"section":64},{"id":114,"disease":115,"label":116,"population":119,"type":122,"unit":28,"dose":123,"refs":128,"notes":131},"tn","trigeminal-neuralgia",{"fa":117,"en":118},"نورالژی سه‌قلو — روز اول ۱۰۰ mg دو بار، افزایش تا رفع درد (حداکثر ۱۲۰۰ mg در روز)","Trigeminal neuralgia — day 1: 100 mg twice daily, increase until pain-free (max 1,200 mg\u002Fday)",{"minAge":120},{"value":121,"unit":56},18,"titration",{"dividedDoses":61,"titration":124},{"start":27,"increment":27,"incrementEveryDays":5,"targetMin":125,"targetMax":126,"max":127},400,800,1200,[129],{"source":33,"section":130},"Dosage and Administration — Trigeminal Neuralgia",[132],{"text":133,"refs":136},{"fa":134,"en":135},"افزایش روزانه حداکثر ۲۰۰ mg (۱۰۰ mg هر ۱۲ ساعت) و فقط در حد نیاز برای رفع درد. نگهدارنده بیشتر بیماران ۴۰۰ تا ۸۰۰ mg در روز. هر ۳ ماه تلاش برای کمترین دوز یا قطع. مسکن ساده نیست.","Increase by up to 200 mg\u002Fday (100 mg every 12 h) only as needed for pain freedom. Most maintain on 400–800 mg\u002Fday. Try to reduce to the minimum or stop every 3 months. Not a simple analgesic.",[137,138],{"source":33,"section":130},{"source":33,"section":139},"Indications and Usage",[141],{"id":142,"severity":143,"text":144,"refs":147},"ci","block",{"fa":145,"en":146},"سابقه سرکوب مغز استخوان؛ حساسیت به کاربامازپین یا ضدافسردگی‌های سه‌حلقه‌ای؛ MAOI.","History of bone marrow depression; hypersensitivity to carbamazepine or tricyclics; MAOIs.",[148],{"source":33,"section":149},"Contraindications",[151],{"text":152,"refs":155},{"fa":153,"en":154},"هشدار جعبه‌ای: واکنش‌های پوستی کشنده (SJS\u002FTEN) مرتبط با آلل HLA-B*1502 (خطر حدود ۱۰ برابر در برخی جمعیت‌های آسیایی)؛ آپلاستیک آنمی و آگرانولوسیتوز.","Boxed warning: fatal skin reactions (SJS\u002FTEN) linked to HLA-B*1502 (about 10× risk in some Asian populations); aplastic anemia and agranulocytosis.",[156],{"source":33,"section":157},"WARNINGS (boxed): SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE",[],[],[],{"status":162,"reviewer":163,"date":163},"unverified",null,[165,170,175,180,183],{"regimen":48,"formulation":22,"input":166,"expect":168},{"ageYears":167,"weightKg":60},4,{"perDose":40,"tabletsPerDoseRounded":169},0.5,{"regimen":77,"formulation":22,"input":171,"expect":174},{"ageYears":172,"weightKg":173},8,25,{"tabletsPerDoseRounded":169},{"regimen":97,"formulation":22,"input":176,"expect":179},{"ageYears":177,"weightKg":178},30,70,{"tabletsPerDoseRounded":5},{"regimen":48,"formulation":36,"input":181,"expect":182},{"ageYears":167,"weightKg":60},{"perDose":40,"mlPerDose":41},{"regimen":114,"formulation":36,"input":184,"expect":186},{"ageYears":185,"weightKg":178},60,{"perDose":40,"mlPerDose":41},[188],"N03AF01",{"status":190,"forms":191,"refs":220},"registered",[192,196,200,204,208,212,216],{"code":193,"en":194,"fa":195},"09437","CARBAMAZEPINE 100MG\u002F5ML 120ML SUSP","سوسپانسیون کاربامازپین ۱۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":197,"en":198,"fa":199},"14911","CARBAMAZEPINE 100MG\u002F5ML 250ML SYRUP","شربت کاربامازپین ۱۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۲۵۰ میلی‌لیتر",{"code":201,"en":202,"fa":203},"00208","CARBAMAZEPINE 200MG TAB","قرص کاربامازپین ۲۰۰ میلی‌گرم",{"code":205,"en":206,"fa":207},"10690","CARBAMAZEPINE 300MG SR TAB","قرص آهسته‌رهش کاربامازپین ۳۰۰ میلی‌گرم",{"code":209,"en":210,"fa":211},"02114","CARBAMAZEPINE SR 200MG TAB","قرص آهسته‌رهش کاربامازپین ۲۰۰ میلی‌گرم",{"code":213,"en":214,"fa":215},"01420","CARBAMAZEPINE SR 400MG TAB","قرص آهسته‌رهش کاربامازپین ۴۰۰ میلی‌گرم",{"code":217,"en":218,"fa":219},"51864","CARBAMAZEPINE SUSPENSION ORAL 100 mg\u002F5mL 120 mL","سوسپانسیون خوراکی کاربامازپین ۱۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",[221],{"source":222,"section":223,"url":224},"darooyab-generic","G-659\u002FCarbamazepine","https:\u002F\u002Fwww.darooyab.ir\u002FG-659\u002FCarbamazepine",[226,230,234,237,240,243],{"kind":227,"url":228,"label":229},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=207798","ANDA207798",{"kind":231,"url":232,"label":233},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=9f3d91cd-a959-4e07-a51b-8a4e9ba9ece2","FDA Carbamazepine",{"kind":231,"url":235,"label":236},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=0526a054-3eda-49b4-b390-7d5d16e30af8","FDA Carbamazepine susp.",{"kind":238,"url":239,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682237.html",{"kind":241,"url":242,"label":188},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N03AF01",{"kind":244,"url":224,"label":8},"darooyab",{"pregnancy":246,"lactation":255,"pediatric":263,"geriatric":272},{"level":247,"text":248,"quote":251,"refs":252},"avoid",{"fa":249,"en":250},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Carbamazepine can cause fetal harm when administered to a pregnant woman.",[253],{"source":33,"section":254},"Precautions\u002FWarnings – Usage in Pregnancy",{"level":247,"text":256,"quote":259,"refs":260},{"fa":257,"en":258},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in nursing infants from carbamazepine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[261],{"source":33,"section":262},"Precautions\u002FWarnings – Nursing Mothers",{"level":264,"text":265,"quote":268,"refs":269},"caution",{"fa":266,"en":267},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Substantial evidence of carbamazepine's effectiveness for use in the management of children with epilepsy (see INDICATIONS AND USAGE for specific seizure types) is derived from clinical investigations performed in adults and from studies in several in vitro systems which support the conclusion that (1) the …",[270],{"source":33,"section":271},"Precautions\u002FWarnings – Pediatric Use",{"level":264,"text":273,"quote":276,"refs":277},{"fa":274,"en":275},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","No systematic studies in geriatric patients have been conducted.",[278],{"source":33,"section":279},"Precautions\u002FWarnings – Geriatric Use",{"kind":281,"refs":282,"id":229},"ANDA",[283],{"source":33,"section":284},"SPL approval \u002F marketing category",1792191878374]