[{"data":1,"prerenderedAt":224},["ShallowReactive",2],{"drug-carbidopa-levodopa":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":72,"contraindications":100,"warnings":110,"renal":111,"monitoring":112,"interactions":113,"review":114,"examples":117,"atc":127,"iran":129,"links":165,"populations":184,"usApproval":219},"carbidopa-levodopa",1,{"fa":7,"en":8},"کاربیدوپا-لوودوپا","Carbidopa\u002Flevodopa","nervous-system",{"fa":11,"en":12},"پیش‌ساز دوپامین","Dopamine precursor",[14],{"name":15,"market":16},"Sinemet","US",[18,19,20,21,22],"sinemet","سینمت","لوودوپا","کاربیدوپا لوودوپا","پارکینسون",[24,46,59],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"components":32,"markets":41,"refs":42},"tab-10-100","tablet","oral","10\u002F100 mg tablet (carbidopa\u002Flevodopa)",{"amount":30,"unit":31,"perUnit":26},100,"mg",{"carbidopa":33,"levodopa":38},{"name":34,"amount":37,"unit":31},{"fa":35,"en":36},"کاربیدوپا","Carbidopa",10,{"name":39,"amount":30,"unit":31},{"fa":20,"en":40},"Levodopa",[16],[43],{"source":44,"section":45},"fda-carbidopalevodopa","How Supplied",{"id":47,"form":26,"route":27,"label":48,"concentration":49,"components":50,"markets":56,"refs":57},"tab-25-100","25\u002F100 mg tablet (carbidopa\u002Flevodopa)",{"amount":30,"unit":31,"perUnit":26},{"carbidopa":51,"levodopa":54},{"name":52,"amount":53,"unit":31},{"fa":35,"en":36},25,{"name":55,"amount":30,"unit":31},{"fa":20,"en":40},[16],[58],{"source":44,"section":45},{"id":60,"form":26,"route":27,"label":61,"concentration":62,"components":64,"markets":69,"refs":70},"tab-25-250","25\u002F250 mg tablet (carbidopa\u002Flevodopa)",{"amount":63,"unit":31,"perUnit":26},250,{"carbidopa":65,"levodopa":67},{"name":66,"amount":53,"unit":31},{"fa":35,"en":36},{"name":68,"amount":63,"unit":31},{"fa":20,"en":40},[16],[71],{"source":44,"section":45},[73],{"id":74,"disease":75,"label":76,"population":79,"type":83,"unit":31,"dose":84,"refs":86,"doseComponent":89,"allowedFormulations":90,"notes":91},"pd","parkinsons",{"fa":77,"en":78},"پارکینسون — شروع ۱ قرص ۲۵\u002F۱۰۰ سه بار در روز","Parkinson’s — start one 25\u002F100 tablet three times daily",{"minAge":80},{"value":81,"unit":82},18,"year","fixed",{"perDose":30,"dosesPerDay":85},3,[87],{"source":44,"section":88},"Dosage and Administration, Usual Initial Dosage","levodopa",[47],[92],{"text":93,"refs":96},{"fa":94,"en":95},"هر روز یا یک روز در میان یک قرص اضافه تا ۸ قرص ۲۵\u002F۱۰۰ در روز. کاربیدوپا ۷۰ تا ۱۰۰ mg\u002Fday برای اشباع لازم است.","Add one tablet every day or every other day up to eight 25\u002F100 tablets per day. About 70–100 mg\u002Fday carbidopa is needed to saturate decarboxylase.",[97,98],{"source":44,"section":88},{"source":44,"section":99},"Dosage and Administration",[101],{"id":102,"severity":103,"text":104,"refs":107},"ci","block",{"fa":105,"en":106},"همراه MAOIهای غیرانتخابی؛ حساسیت؛ گلوکوم زاویه بسته.","With nonselective MAOIs; hypersensitivity; narrow-angle glaucoma.",[108],{"source":44,"section":109},"Contraindications",[],[],[],[],{"status":115,"reviewer":116,"date":116},"unverified",null,[118,123],{"regimen":74,"formulation":47,"input":119,"expect":122},{"ageYears":120,"weightKg":121},65,70,{"perDose":30,"tabletsPerDoseRounded":5},{"regimen":74,"formulation":60,"input":124,"expect":125},{"ageYears":120,"weightKg":121},{"status":126},"blocked",[128],"N04BA02",{"status":130,"forms":131,"refs":160},"registered",[132,136,140,144,148,152,156],{"code":133,"en":134,"fa":135},"00747","LEVODOPA-C 110MG TAB","قرص لوودوپا–C ۱۱۰ میلی‌گرم",{"code":137,"en":138,"fa":139},"02383","LEVODOPA-C 125MG TAB","قرص لوودوپا–C ۱۲۵ میلی‌گرم",{"code":141,"en":142,"fa":143},"06733","LEVODOPA-C 275MG TAB","قرص لوودوپا–C ۲۷۵ میلی‌گرم",{"code":145,"en":146,"fa":147},"10062","LEVODOPA-C 62.5MG TAB","قرص لوودوپا–C ۶۲٫۵ میلی‌گرم",{"code":149,"en":150,"fa":151},"00748","LEVODOPA-C FORTE 250 TAB","قرص لوودوپا–C فورت ۲۵۰",{"code":153,"en":154,"fa":155},"52301","LEVODOPA \u002F CARBIDOPA TABLET ORAL 100 mg\u002F25 mg","قرص لوودوپا \u002F کاربیدوپا ۱۰۰ میلی‌گرم \u002F ۲۵ میلی‌گرم",{"code":157,"en":158,"fa":159},"52479","LEVODOPA \u002F CARBIDOPA TABLET, EXTENDED RELEASE ORAL 200 mg\u002F50 mg","قرص آهسته‌رهش لوودوپا \u002F کاربیدوپا ۲۰۰ میلی‌گرم \u002F ۵۰ میلی‌گرم",[161],{"source":162,"section":163,"url":164},"darooyab-generic","G-4529\u002FLevodopa-C","https:\u002F\u002Fwww.darooyab.ir\u002FG-4529\u002FLevodopa-C",[166,170,174,178,181],{"kind":167,"url":168,"label":169},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=074260","ANDA074260",{"kind":171,"url":172,"label":173},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=4ace5274-b6cf-414c-b9c0-f60e28a9cea5","FDA Carbidopa-levodopa",{"kind":175,"url":176,"label":177},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601068.html","Levodopa and Carbidopa",{"kind":179,"url":180,"label":128},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N04BA02",{"kind":182,"url":164,"label":183},"darooyab","Levodopa-C",{"pregnancy":185,"lactation":194,"pediatric":202,"geriatric":211},{"level":186,"text":187,"quote":190,"refs":191},"caution",{"fa":188,"en":189},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","No teratogenic effects were observed in a study in mice receiving up to 20 times the maximum recommended human dose of carbidopa and levodopa.",[192],{"source":44,"section":193},"Precautions\u002FWarnings – Pregnancy",{"level":186,"text":195,"quote":198,"refs":199},{"fa":196,"en":197},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution should be exercised when carbidopa and levodopa is administered to a nursing woman.",[200],{"source":44,"section":201},"Precautions\u002FWarnings – Nursing Mothers",{"level":203,"text":204,"quote":207,"refs":208},"not-established",{"fa":205,"en":206},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[209],{"source":44,"section":210},"Precautions\u002FWarnings – Pediatric Use",{"level":186,"text":212,"quote":215,"refs":216},{"fa":213,"en":214},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In the clinical efficacy trials for carbidopa and levodopa, almost half of the patients were older than 65, but few were older than 75.",[217],{"source":44,"section":218},"Precautions\u002FWarnings – Geriatric Use",{"kind":220,"refs":221,"id":169},"ANDA",[222],{"source":44,"section":223},"SPL approval \u002F marketing category",1792191878624]