[{"data":1,"prerenderedAt":471},["ShallowReactive",2],{"drug-cefixime":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":53,"contraindications":257,"warnings":277,"renal":299,"monitoring":309,"interactions":310,"review":311,"examples":314,"atc":362,"iran":364,"links":416,"populations":433,"usApproval":466},"cefixime",1,{"fa":7,"en":8},"سفیکسیم","Cefixime","anti-infectives",{"fa":11,"en":12},"سفالوسپورین نسل سوم","Third-generation cephalosporin",[14],{"name":15,"market":16},"Suprax","US",[18,19],"cefixim","سفکسیم",[21,35,43],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"susp-100-5","suspension","oral","100 mg \u002F 5 mL",{"amount":27,"unit":28,"perVolumeMl":29},100,"mg",5,[16],[32],{"source":33,"section":34},"fda-cefixime","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"susp-200-5","200 mg \u002F 5 mL",{"amount":39,"unit":28,"perVolumeMl":29},200,[16],[42],{"source":33,"section":34},{"id":44,"form":45,"route":24,"label":46,"concentration":47,"markets":50,"refs":51},"cap-400","capsule","400 mg capsule",{"amount":48,"unit":28,"perUnit":45,"scored":49},400,false,[16],[52],{"source":33,"section":34},[54,91,114,132,149,175,197,215,232,246],{"id":55,"disease":56,"label":57,"population":60,"type":68,"unit":28,"dose":69,"refs":71,"limits":76,"allowedFormulations":83,"notes":84},"acute-otitis-media-od","acute-otitis-media",{"fa":58,"en":59},"اوتیت مدیا — ۸ mg\u002Fkg یک‌بار در روز","Otitis media — 8 mg\u002Fkg once daily",{"minAge":61,"maxAge":64,"maxWeightKg":67},{"value":62,"unit":63},6,"month",{"value":65,"unit":66},13,"year",45,"weightBased",{"perKgPerDay":70,"dividedDoses":5},8,[72,74],{"source":33,"section":73},"2.2",{"source":33,"section":75},"1",{"maxPerDay":48,"refs":77},[78],{"source":33,"section":79,"note":80},"2.2, Table 1",{"fa":81,"en":82},"۴۵٫۱ کیلوگرم به بالا: ۴۰۰ mg در روز","≥45.1 kg: 400 mg\u002Fday",[22,36],[85],{"text":86,"refs":89},{"fa":87,"en":88},"در اوتیت مدیا فقط سوسپانسیون؛ قرص\u002Fکپسول جایگزین سوسپانسیون نشود (سطح خونی بالاتر با سوسپانسیون).","Treat otitis media with the suspension; do not substitute the tablet or capsule.",[90],{"source":33,"section":73},{"id":92,"disease":56,"label":93,"population":96,"type":68,"unit":28,"dose":99,"refs":101,"limits":104,"allowedFormulations":108,"notes":109},"acute-otitis-media-q12",{"fa":94,"en":95},"اوتیت مدیا — ۴ mg\u002Fkg هر ۱۲ ساعت","Otitis media — 4 mg\u002Fkg every 12 h",{"minAge":97,"maxAge":98,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":100},2,[102,103],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":105},[106],{"source":33,"section":79,"note":107},{"fa":81,"en":82},[22,36],[110],{"text":111,"refs":112},{"fa":87,"en":88},[113],{"source":33,"section":73},{"id":115,"disease":116,"label":117,"population":120,"type":68,"unit":28,"dose":123,"refs":124,"limits":127,"allowedFormulations":131},"urinary-tract-infection-od","urinary-tract-infection",{"fa":118,"en":119},"عفونت ادراری بدون عارضه — ۸ mg\u002Fkg یک‌بار در روز","Uncomplicated UTI — 8 mg\u002Fkg once daily",{"minAge":121,"maxAge":122,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":5},[125,126],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":128},[129],{"source":33,"section":79,"note":130},{"fa":81,"en":82},[22,36],{"id":133,"disease":116,"label":134,"population":137,"type":68,"unit":28,"dose":140,"refs":141,"limits":144,"allowedFormulations":148},"urinary-tract-infection-q12",{"fa":135,"en":136},"عفونت ادراری بدون عارضه — ۴ mg\u002Fkg هر ۱۲ ساعت","Uncomplicated UTI — 4 mg\u002Fkg every 12 h",{"minAge":138,"maxAge":139,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":100},[142,143],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":145},[146],{"source":33,"section":79,"note":147},{"fa":81,"en":82},[22,36],{"id":150,"disease":151,"label":152,"population":155,"type":68,"unit":28,"dose":158,"refs":159,"limits":162,"allowedFormulations":166,"notes":167},"streptococcal-pharyngitis-od","streptococcal-pharyngitis",{"fa":153,"en":154},"فارنژیت\u002Fتونسیلیت — ۸ mg\u002Fkg یک‌بار در روز","Pharyngitis\u002Ftonsillitis — 8 mg\u002Fkg once daily",{"minAge":156,"maxAge":157,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":5},[160,161],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":163},[164],{"source":33,"section":79,"note":165},{"fa":81,"en":82},[22,36],[168],{"text":169,"refs":172},{"fa":170,"en":171},"برای عفونت استرپتوکوک پیوژنز حداقل ۱۰ روز.","For Streptococcus pyogenes infections treat at least 10 days.",[173],{"source":33,"section":174},"2.1",{"id":176,"disease":151,"label":177,"population":180,"type":68,"unit":28,"dose":183,"refs":184,"limits":187,"allowedFormulations":191,"notes":192},"streptococcal-pharyngitis-q12",{"fa":178,"en":179},"فارنژیت\u002Fتونسیلیت — ۴ mg\u002Fkg هر ۱۲ ساعت","Pharyngitis\u002Ftonsillitis — 4 mg\u002Fkg every 12 h",{"minAge":181,"maxAge":182,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":100},[185,186],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":188},[189],{"source":33,"section":79,"note":190},{"fa":81,"en":82},[22,36],[193],{"text":194,"refs":195},{"fa":170,"en":171},[196],{"source":33,"section":174},{"id":198,"disease":199,"label":200,"population":203,"type":68,"unit":28,"dose":206,"refs":207,"limits":210,"allowedFormulations":214},"aecb-od","aecb",{"fa":201,"en":202},"تشدید برونشیت مزمن — ۸ mg\u002Fkg یک‌بار در روز","Acute exacerbation of chronic bronchitis — 8 mg\u002Fkg once daily",{"minAge":204,"maxAge":205,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":5},[208,209],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":211},[212],{"source":33,"section":79,"note":213},{"fa":81,"en":82},[22,36],{"id":216,"disease":199,"label":217,"population":220,"type":68,"unit":28,"dose":223,"refs":224,"limits":227,"allowedFormulations":231},"aecb-q12",{"fa":218,"en":219},"تشدید برونشیت مزمن — ۴ mg\u002Fkg هر ۱۲ ساعت","Acute exacerbation of chronic bronchitis — 4 mg\u002Fkg every 12 h",{"minAge":221,"maxAge":222,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":100},[225,226],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":228},[229],{"source":33,"section":79,"note":230},{"fa":81,"en":82},[22,36],{"id":233,"disease":116,"label":234,"population":237,"type":238,"unit":28,"dose":239,"refs":240},"adult",{"fa":235,"en":236},"بزرگسال، بیش از ۴۵ کیلوگرم یا بالای ۱۲ سال — ۴۰۰ mg روزانه","Adults, >45 kg or >12 years — 400 mg daily",{},"fixed",{"perDose":48,"dosesPerDay":5},[241,242],{"source":33,"section":174},{"source":33,"section":73,"note":243},{"fa":244,"en":245},"بیش از ۴۵ کیلوگرم یا بالای ۱۲ سال: دوز بزرگسال",">45 kg or older than 12 years: adult dose",{"id":247,"disease":247,"label":248,"population":251,"type":238,"unit":28,"dose":253,"refs":254,"durationDays":256},"gonorrhea",{"fa":249,"en":250},"سوزاک بدون عارضه — ۴۰۰ mg تک‌دوز","Uncomplicated gonorrhea — single 400 mg dose",{"minAge":252},{"value":65,"unit":66},{"perDose":48,"dosesPerDay":5},[255],{"source":33,"section":174},{"min":5,"max":5},[258,267],{"id":259,"severity":260,"text":261,"refs":264},"hypersensitivity","block",{"fa":262,"en":263},"آلرژی شناخته‌شده به سفیکسیم یا سایر سفالوسپورین‌ها.","Known allergy to cefixime or other cephalosporins.",[265],{"source":33,"section":266},"4",{"id":268,"severity":260,"rule":269,"text":271,"refs":274},"under-6-months",{"maxAge":270},{"value":62,"unit":63},{"fa":272,"en":273},"بی‌خطری و اثربخشی زیر ۶ ماه ثابت نشده است.","Safety and effectiveness below 6 months not established.",[275],{"source":33,"section":276},"8.4",[278,285,292],{"text":279,"refs":282},{"fa":280,"en":281},"واکنش‌های حساسیتی","Hypersensitivity reactions",[283],{"source":33,"section":284},"5.1",{"text":286,"refs":289},{"fa":287,"en":288},"اسهال مرتبط با کلستریدیوئیدس دیفیسیل","Clostridioides difficile-associated diarrhea",[290],{"source":33,"section":291},"5.2",{"text":293,"refs":296},{"fa":294,"en":295},"اثر بر انعقاد (افزایش زمان پروترومبین)","Coagulation effects",[297],{"source":33,"section":298},"5.4",[300],{"egfrBelow":301,"severity":302,"text":303,"refs":306},60,"warn",{"fa":304,"en":305},"کلیرانس کمتر از ۶۰: کاهش دوز طبق جدول ۲ برچسب (بزرگسالان).","CrCl \u003C60 mL\u002Fmin: reduce per label Table 2 (adults).",[307],{"source":33,"section":308},"2.3",[],[],{"status":312,"reviewer":313,"date":313},"unverified",null,[315,321,326,332,336,340,344,347,350,354,359],{"regimen":55,"formulation":22,"input":316,"expect":318},{"ageYears":100,"weightKg":317},12,{"perDose":319,"mlPerDose":320},96,4.8,{"regimen":92,"formulation":22,"input":322,"expect":323},{"ageYears":100,"weightKg":317},{"perDose":324,"mlPerDose":325},48,2.4,{"regimen":115,"formulation":36,"input":327,"expect":330},{"ageYears":328,"weightKg":329},10,40,{"perDose":331,"mlPerDose":70},320,{"regimen":133,"formulation":36,"input":333,"expect":334},{"ageYears":328,"weightKg":329},{"perDose":335},160,{"regimen":150,"formulation":36,"input":337,"expect":339},{"ageYears":62,"weightKg":338},20,{"perDose":335},{"regimen":176,"formulation":22,"input":341,"expect":342},{"ageYears":62,"weightKg":338},{"perDose":343},80,{"regimen":198,"formulation":36,"input":345,"expect":346},{"ageYears":62,"weightKg":338},{"perDose":335},{"regimen":216,"formulation":36,"input":348,"expect":349},{"ageYears":62,"weightKg":338},{"perDose":343},{"regimen":55,"formulation":44,"input":351,"expect":352},{"ageYears":62,"weightKg":338},{"status":353},"blocked",{"regimen":233,"formulation":44,"input":355,"expect":358},{"ageYears":356,"weightKg":357},30,70,{"tabletsPerDoseRounded":5},{"regimen":247,"formulation":44,"input":360,"expect":361},{"ageYears":338,"weightKg":301},{"perDose":48},[363],"J01DD08",{"status":365,"forms":366,"refs":411},"registered",[367,371,375,379,383,387,391,395,399,401,404,408],{"code":368,"en":369,"fa":370},"02419","CEFIXIME 100MG\u002F5ML 100ML FOR SUSP","سوسپانسیون سفیکسیم ۱۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۰۰ میلی‌لیتر",{"code":372,"en":373,"fa":374},"03849","CEFIXIME 100MG\u002F5ML 50ML FOR SUSP","سوسپانسیون سفیکسیم ۱۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۵۰ میلی‌لیتر",{"code":376,"en":377,"fa":378},"02115","CEFIXIME 100MG\u002FSACHET FOR SUSP","سوسپانسیون سفیکسیم ۱۰۰ میلی‌گرم",{"code":380,"en":381,"fa":382},"07495","CEFIXIME 200MG CAP","کپسول سفیکسیم ۲۰۰ میلی‌گرم",{"code":384,"en":385,"fa":386},"00226","CEFIXIME 200MG TAB","قرص سفیکسیم ۲۰۰ میلی‌گرم",{"code":388,"en":389,"fa":390},"07496","CEFIXIME 400MG CAP","کپسول سفیکسیم ۴۰۰ میلی‌گرم",{"code":392,"en":393,"fa":394},"00227","CEFIXIME 400MG TAB","قرص سفیکسیم ۴۰۰ میلی‌گرم",{"code":396,"en":397,"fa":398},"00228","CEFIXIME 50MG\u002FSACHET FOR PED SUSP","سوسپانسیون سفیکسیم ۵۰ میلی‌گرم \u002F پد",{"code":400,"en":369,"fa":370},"51971",{"code":400,"en":402,"fa":403},"CEFIXIME 200MG\u002F5ML 50ML FOR SUSP","سوسپانسیون سفیکسیم ۲۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۵۰ میلی‌لیتر",{"code":405,"en":406,"fa":407},"51889","CEFIXIME POWDER, FOR SUSPENSION ORAL 100 mg\u002F5 mL 50 mL","سوسپانسیون خوراکی سفیکسیم ۱۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۵۰ میلی‌لیتر",{"code":409,"en":410,"fa":394},"52222","CEFIXIME TABLET ORAL 400 mg",[412],{"source":413,"section":414,"url":415},"darooyab-generic","G-325\u002FCefixime","https:\u002F\u002Fwww.darooyab.ir\u002FG-325\u002FCefixime",[417,421,425,428,431],{"kind":418,"url":419,"label":420},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=065129","ANDA065129",{"kind":422,"url":423,"label":424},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=6d68dbd9-7d75-4ff1-91db-79ff8ae879ec","FDA Cefixime",{"kind":426,"url":427,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa690007.html",{"kind":429,"url":430,"label":363},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01DD08",{"kind":432,"url":415,"label":8},"darooyab",{"pregnancy":434,"lactation":443,"pediatric":451,"geriatric":458},{"level":435,"text":436,"quote":439,"refs":440},"caution",{"fa":437,"en":438},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from published observational studies, case series, and case reports over several decades with cephalosporin use, including cefixime, in pregnant women have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes (see Data) .",[441],{"source":33,"section":442},"8.1",{"level":435,"text":444,"quote":447,"refs":448},{"fa":445,"en":446},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no available data on the presence of cefixime in human milk, the effects on the breast-fed infant, or the effects on milk production.",[449],{"source":33,"section":450},"8.2",{"level":435,"text":452,"quote":455,"refs":456},{"fa":453,"en":454},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of cefixime have been established in pediatric patients 6 months of age and older.",[457],{"source":33,"section":276},{"level":435,"text":459,"quote":462,"refs":463},{"fa":460,"en":461},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Clinical studies did not include sufficient numbers of subjects aged 65 and older to determine whether they respond differently than younger subjects.",[464],{"source":33,"section":465},"8.5",{"kind":467,"refs":468,"id":420},"ANDA",[469],{"source":33,"section":470},"SPL approval \u002F marketing category",1792191873940]