[{"data":1,"prerenderedAt":490},["ShallowReactive",2],{"drug-ciprofloxacin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":70,"contraindications":298,"warnings":317,"renal":318,"monitoring":319,"interactions":320,"review":321,"examples":324,"atc":382,"iran":384,"links":428,"populations":451,"usApproval":485},"ciprofloxacin",1,{"fa":7,"en":8},"سیپروفلوکساسین","Ciprofloxacin","anti-infectives",{"fa":11,"en":12},"فلوروکینولون","Fluoroquinolone",[14],{"name":15,"market":16},"Cipro","US",[18,19,7,20],"cipro","سیپرو","سیپروفلوکسازین",[22,36,44,52,63],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-250","tablet","oral","250 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},250,"mg",false,[16],[33],{"source":34,"section":35},"fda-ciprofloxacin","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-500","500 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},500,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-750","750 mg tablet",{"amount":48,"unit":29,"perUnit":24,"scored":30},750,[16],[51],{"source":34,"section":35},{"id":53,"form":54,"route":25,"label":55,"concentration":56,"markets":58,"refs":59},"susp-250","suspension","5% (250 mg \u002F 5 mL) oral suspension",{"amount":28,"unit":29,"perVolumeMl":57},5,[16],[60],{"source":61,"section":62},"fda-ciprosusp","Dosage Forms and Strengths",{"id":64,"form":54,"route":25,"label":65,"concentration":66,"markets":67,"refs":68},"susp-500","10% (500 mg \u002F 5 mL) oral suspension",{"amount":40,"unit":29,"perVolumeMl":57},[16],[69],{"source":61,"section":62},[71,91,104,117,130,144,157,169,181,211,236,250,270],{"id":72,"disease":73,"label":74,"population":77,"type":81,"unit":29,"dose":82,"refs":84,"durationDays":87,"allowedFormulations":90},"uti","urinary-tract-infection",{"fa":75,"en":76},"عفونت ادراری: ۲۵۰ تا ۵۰۰ mg هر ۱۲ ساعت، ۷ تا ۱۴ روز","Urinary tract infection: 250–500 mg every 12 h, 7–14 days",{"minAge":78},{"value":79,"unit":80},18,"year","fixed",{"perDose":28,"perDoseMax":40,"dosesPerDay":83},2,[85],{"source":34,"section":86},"2.1, Table 1",{"min":88,"max":89},7,14,[23,37,45],{"id":92,"disease":73,"label":93,"population":96,"type":81,"unit":29,"dose":98,"refs":99,"durationDays":101,"allowedFormulations":103},"cystitis",{"fa":94,"en":95},"سیستیت حاد بدون عارضه: ۲۵۰ mg هر ۱۲ ساعت، ۳ روز","Acute uncomplicated cystitis: 250 mg every 12 h, 3 days",{"minAge":97},{"value":79,"unit":80},{"perDose":28,"dosesPerDay":83},[100],{"source":34,"section":86},{"min":102,"max":102},3,[23,37,45],{"id":105,"disease":106,"label":107,"population":110,"type":81,"unit":29,"dose":112,"refs":113,"durationDays":115,"allowedFormulations":116},"sssi","skin-soft-tissue-infection",{"fa":108,"en":109},"عفونت پوست و بافت نرم: ۵۰۰ تا ۷۵۰ mg هر ۱۲ ساعت، ۷ تا ۱۴ روز","Skin and skin structure: 500–750 mg every 12 h, 7–14 days",{"minAge":111},{"value":79,"unit":80},{"perDose":40,"perDoseMax":48,"dosesPerDay":83},[114],{"source":34,"section":86},{"min":88,"max":89},[23,37,45],{"id":118,"disease":119,"label":120,"population":123,"type":81,"unit":29,"dose":125,"refs":126,"durationDays":128,"allowedFormulations":129},"lrti","lower-respiratory-infection",{"fa":121,"en":122},"عفونت تنفسی تحتانی: ۵۰۰ تا ۷۵۰ mg هر ۱۲ ساعت، ۷ تا ۱۴ روز","Lower respiratory tract: 500–750 mg every 12 h, 7–14 days",{"minAge":124},{"value":79,"unit":80},{"perDose":40,"perDoseMax":48,"dosesPerDay":83},[127],{"source":34,"section":86},{"min":88,"max":89},[23,37,45],{"id":131,"disease":132,"label":133,"population":136,"type":81,"unit":29,"dose":138,"refs":139,"durationDays":141,"allowedFormulations":143},"sinusitis","acute-bacterial-sinusitis",{"fa":134,"en":135},"سینوزیت حاد: ۵۰۰ mg هر ۱۲ ساعت، ۱۰ روز","Acute sinusitis: 500 mg every 12 h, 10 days",{"minAge":137},{"value":79,"unit":80},{"perDose":40,"dosesPerDay":83},[140],{"source":34,"section":86},{"min":142,"max":142},10,[23,37,45],{"id":145,"disease":146,"label":147,"population":150,"type":81,"unit":29,"dose":152,"refs":153,"durationDays":155,"allowedFormulations":156},"diarrhea","acute-diarrhoea",{"fa":148,"en":149},"اسهال عفونی: ۵۰۰ mg هر ۱۲ ساعت، ۵ تا ۷ روز","Infectious diarrhoea: 500 mg every 12 h, 5–7 days",{"minAge":151},{"value":79,"unit":80},{"perDose":40,"dosesPerDay":83},[154],{"source":34,"section":86},{"min":57,"max":88},[23,37,45],{"id":158,"disease":158,"label":159,"population":162,"type":81,"unit":29,"dose":164,"refs":165,"durationDays":167,"allowedFormulations":168},"typhoid",{"fa":160,"en":161},"حصبه: ۵۰۰ mg هر ۱۲ ساعت، ۱۰ روز","Typhoid fever: 500 mg every 12 h, 10 days",{"minAge":163},{"value":79,"unit":80},{"perDose":40,"dosesPerDay":83},[166],{"source":34,"section":86},{"min":142,"max":142},[23,37,45],{"id":170,"disease":170,"label":171,"population":174,"type":81,"unit":29,"dose":176,"refs":177,"durationDays":179,"allowedFormulations":180},"gonorrhea",{"fa":172,"en":173},"سوزاک بدون عارضه: ۲۵۰ mg تک‌دوز","Uncomplicated gonorrhoea: 250 mg single dose",{"minAge":175},{"value":79,"unit":80},{"perDose":28,"dosesPerDay":5},[178],{"source":34,"section":86},{"min":5,"max":5},[23,37,45],{"id":182,"disease":73,"label":183,"population":186,"type":189,"unit":29,"dose":190,"refs":193,"limits":196,"durationDays":199,"notes":201,"allowedFormulations":210},"peds-cuti",{"fa":184,"en":185},"UTI عارضه‌دار\u002Fپیلونفریت — ۱ تا ۱۷ سال: ۱۰ تا ۲۰ mg\u002Fkg هر ۱۲ ساعت","Complicated UTI\u002Fpyelonephritis — 1–17 y: 10–20 mg\u002Fkg every 12 h",{"minAge":187,"maxAge":188},{"value":5,"unit":80},{"value":79,"unit":80},"weightBased",{"perKgPerDose":142,"perKgPerDoseMax":191,"intervalHours":192},20,12,[194],{"source":34,"section":195},"2.2, Table 3",{"maxPerDose":48,"refs":197},[198],{"source":34,"section":195},{"min":142,"max":200},21,[202],{"text":203,"refs":206},{"fa":204,"en":205},"حداکثر ۷۵۰ mg در هر دوز حتی بالای ۵۱ kg. سیپروفلوکساسین در کودکان داروی خط اول نیست (عوارض مفصلی).","Max 750 mg per dose even above 51 kg. Not a first-choice drug in children (joint adverse events).",[207,208],{"source":34,"section":195},{"source":34,"section":209},"8.4",[23,37,45],{"id":212,"disease":213,"label":214,"population":217,"type":189,"unit":29,"dose":220,"refs":221,"limits":224,"durationDays":227,"notes":228},"cuti-child","pyelonephritis",{"fa":215,"en":216},"عفونت ادراری عارضه‌دار \u002F پیلونفریت — ۱ تا ۱۷ سال: ۱۰ تا ۲۰ mg\u002Fkg هر ۱۲ ساعت","Complicated UTI \u002F pyelonephritis — 1–17 y: 10–20 mg\u002Fkg every 12 h",{"minAge":218,"maxAge":219},{"value":5,"unit":80},{"value":79,"unit":80},{"perKgPerDose":142,"perKgPerDoseMax":191,"intervalHours":192},[222],{"source":61,"section":223},"Dosage and Administration — Pediatric Dosage Guidelines",{"maxPerDose":48,"refs":225},[226],{"source":61,"section":223},{"min":142,"max":200},[229],{"text":230,"refs":233},{"fa":231,"en":232},"حداکثر ۷۵۰ mg در هر دوز حتی بالای ۵۱ kg. در کودکان خطر عوارض مفصلی؛ داروی خط اول نیست.","Max 750 mg per dose even above 51 kg. Joint adverse events in children; not first choice.",[234,235],{"source":61,"section":223},{"source":61,"section":209},{"id":237,"disease":237,"label":238,"population":241,"type":81,"unit":29,"dose":243,"refs":244,"durationDays":247,"allowedFormulations":249},"prostatitis",{"fa":239,"en":240},"پروستاتیت باکتریایی مزمن — ۵۰۰ mg هر ۱۲ ساعت، ۲۸ روز","Chronic bacterial prostatitis — 500 mg every 12 h, 28 days",{"minAge":242},{"value":79,"unit":80},{"perDose":40,"dosesPerDay":83},[245],{"source":61,"section":246},"Dosage and Administration — Adult Dosage Guidelines",{"min":248,"max":248},28,[23,37,45,53,64],{"id":251,"disease":251,"label":252,"population":255,"type":81,"unit":29,"dose":257,"refs":258,"durationDays":261,"notes":262},"plague",{"fa":253,"en":254},"طاعون (درمان یا پیشگیری) — بزرگسال ۵۰۰ تا ۷۵۰ mg هر ۱۲ ساعت، ۱۴ روز","Plague (treatment or prophylaxis) — adult 500–750 mg every 12 h, 14 days",{"minAge":256},{"value":79,"unit":80},{"perDose":40,"perDoseMax":48,"dosesPerDay":83},[259],{"source":34,"section":260},"2.1",{"min":89,"max":89},[263],{"text":264,"refs":267},{"fa":265,"en":266},"تأیید طاعون بر اساس مطالعات حیوانی است (مطالعه انسانی ممکن نبود). شروع هرچه زودتر پس از تماس یا تشخیص.","Plague approval is based on animal studies (human trials not feasible). Start as soon as possible after exposure or diagnosis.",[268],{"source":34,"section":269},"1.8",{"id":271,"disease":251,"label":272,"population":275,"type":189,"unit":29,"dose":277,"refs":279,"limits":282,"durationDays":285,"allowedFormulations":286,"notes":287},"plague-child",{"fa":273,"en":274},"طاعون — کودک (تولد تا ۱۷ سال): ۱۵ mg\u002Fkg هر ۸ تا ۱۲ ساعت (حداکثر ۵۰۰ mg)، ۱۴ روز","Plague — child (birth–17 y): 15 mg\u002Fkg every 8–12 h (max 500 mg), 14 days",{"maxAge":276},{"value":79,"unit":80},{"perKgPerDose":278,"intervalHours":192},15,[280],{"source":34,"section":281},"2.2",{"maxPerDose":40,"refs":283},[284],{"source":34,"section":281},{"min":89,"max":89},[53,64],[288,292],{"text":289,"refs":290},{"fa":265,"en":266},[291],{"source":34,"section":269},{"text":293,"refs":296},{"fa":294,"en":295},"ماشین‌حساب فاصله را ۱۲ ساعت نشان می‌دهد؛ برچسب ۸ تا ۱۲ ساعت.","The calculator shows 12-hourly; the label allows every 8–12 h.",[297],{"source":34,"section":281},[299,308],{"id":300,"severity":301,"text":302,"refs":305},"ci","block",{"fa":303,"en":304},"حساسیت به سیپروفلوکساسین یا سایر کینولون‌ها؛ مصرف همزمان تیزانیدین.","Hypersensitivity to ciprofloxacin or other quinolones; concomitant tizanidine.",[306],{"source":34,"section":307},"4",{"id":309,"severity":310,"text":311,"refs":314},"boxed","warn",{"fa":312,"en":313},"هشدار جعبه‌ای: تاندونیت و پارگی تاندون، نوروپاتی محیطی، اثرات CNS و تشدید میاستنی گراویس؛ در میاستنی پرهیز شود.","Boxed warning: tendinitis and tendon rupture, peripheral neuropathy, CNS effects and exacerbation of myasthenia gravis; avoid in myasthenia gravis.",[315],{"source":34,"section":316},"Boxed Warning",[],[],[],[],{"status":322,"reviewer":323,"date":323},"unverified",null,[325,330,335,338,342,345,348,351,355,359,364,371,375,378],{"regimen":72,"formulation":23,"input":326,"expect":329},{"ageYears":327,"weightKg":328},40,70,{"perDose":28,"upperPerDose":40},{"regimen":92,"formulation":23,"input":331,"expect":334},{"ageYears":332,"weightKg":333},30,60,{"perDay":40},{"regimen":105,"formulation":37,"input":336,"expect":337},{"ageYears":327,"weightKg":328},{"perDose":40},{"regimen":118,"formulation":37,"input":339,"expect":341},{"ageYears":340,"weightKg":328},50,{"perDose":40},{"regimen":131,"formulation":37,"input":343,"expect":344},{"ageYears":327,"weightKg":328},{"perDose":40},{"regimen":145,"formulation":37,"input":346,"expect":347},{"ageYears":332,"weightKg":328},{"perDose":40},{"regimen":158,"formulation":37,"input":349,"expect":350},{"ageYears":332,"weightKg":328},{"perDose":40},{"regimen":170,"formulation":23,"input":352,"expect":354},{"ageYears":353,"weightKg":333},25,{"perDose":28},{"regimen":182,"formulation":23,"input":356,"expect":358},{"ageYears":357,"weightKg":353},8,{"perDose":28,"upperPerDose":40},{"regimen":182,"formulation":45,"input":360,"expect":363},{"ageYears":361,"weightKg":362},16,90,{"perDose":48},{"regimen":212,"formulation":53,"input":365,"expect":367},{"ageYears":366,"weightKg":191},6,{"perDose":368,"mlPerDose":369,"upperPerDose":370},200,4,400,{"regimen":237,"formulation":37,"input":372,"expect":374},{"ageYears":340,"weightKg":373},80,{"perDose":40,"tabletsPerDoseRounded":5},{"regimen":251,"formulation":37,"input":376,"expect":377},{"ageYears":327,"weightKg":328},{"perDose":40,"tabletsPerDoseRounded":5},{"regimen":271,"formulation":53,"input":379,"expect":380},{"ageYears":366,"weightKg":191},{"perDose":381,"mlPerDose":366},300,[383],"J01MA02",{"status":385,"forms":386,"refs":423},"registered",[387,391,395,399,403,407,411,415,419],{"code":388,"en":389,"fa":390},"09786","CIPROFLOXACIN 250MG\u002F5ML 100ML SUSP","سوسپانسیون سیپروفلوکساسین ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۰۰ میلی‌لیتر",{"code":392,"en":393,"fa":394},"00295","CIPROFLOXACIN HCL 250MG TAB","قرص سیپروفلوکساسین هیدروکلراید ۲۵۰ میلی‌گرم",{"code":396,"en":397,"fa":398},"00296","CIPROFLOXACIN HCL 500MG TAB","قرص سیپروفلوکساسین هیدروکلراید ۵۰۰ میلی‌گرم",{"code":400,"en":401,"fa":402},"10757","CIPROFLOXACIN LACTATE 200MG\u002F100ML INF BOTTLE","محلول انفوزیون در بطری سیپروفلوکساسین لاکتات ۲۰۰ میلی‌گرم \u002F ۱۰۰ میلی‌لیتر",{"code":404,"en":405,"fa":406},"00294","CIPROFLOXACIN LACTATE 200MG\u002F100ML INF P-BAG","محلول انفوزیون سیپروفلوکساسین لاکتات ۲۰۰ میلی‌گرم \u002F ۱۰۰ میلی‌لیتر",{"code":408,"en":409,"fa":410},"02250","CIPROFLOXACIN LACTATE 200MG\u002F20ML INF","محلول انفوزیون سیپروفلوکساسین لاکتات ۲۰۰ میلی‌گرم \u002F ۲۰ میلی‌لیتر",{"code":412,"en":413,"fa":414},"52076","CIPROFLOXACIN INJECTION, SOLUTION INTRAVENOUS 10 mg\u002F1mL 40 mL","فرآورده تزریقی سیپروفلوکساسین ۱۰ میلی‌گرم \u002F ۱ میلی‌لیتر ۴۰ میلی‌لیتر",{"code":416,"en":417,"fa":418},"52435","CIPROFLOXACIN (AS HYDROCHLORIDE) TABLET ORAL 750 mg","قرص سیپروفلوکساسین (معادل هیدروکلراید) ۷۵۰ میلی‌گرم",{"code":420,"en":421,"fa":422},"52801","CIPROFLOXACIN (AS LACTATE) INJECTION, SOLUTION INTRAVENOUS 2 mg\u002F1mL 200 mL","فرآورده تزریقی سیپروفلوکساسین (معادل لاکتات) ۲ میلی‌گرم \u002F ۱ میلی‌لیتر ۲۰۰ میلی‌لیتر",[424],{"source":425,"section":426,"url":427},"darooyab-generic","G-361\u002FCiprofloxacin","https:\u002F\u002Fwww.darooyab.ir\u002FG-361\u002FCiprofloxacin",[429,433,437,440,443,446,449],{"kind":430,"url":431,"label":432},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=076593","ANDA076593",{"kind":434,"url":435,"label":436},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=14c3bc33-201d-492e-9aee-a4d84c813a3d","FDA Ciprofloxacin",{"kind":434,"url":438,"label":439},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0","FDA Cipro (tab+susp)",{"kind":441,"url":442,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa688016.html",{"kind":441,"url":444,"label":445},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa693022.html","Ciprofloxacin Injection",{"kind":447,"url":448,"label":383},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01MA02",{"kind":450,"url":427,"label":8},"darooyab",{"pregnancy":452,"lactation":461,"pediatric":470,"geriatric":477},{"level":453,"text":454,"quote":457,"refs":458},"caution",{"fa":455,"en":456},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Prolonged experience with ciprofloxacin in pregnant women over several decades, based on available published information from case reports, case control studies and observational studies on ciprofloxacin administered during pregnancy, have not identified any drug-associated risk of major birth defects, …",[459],{"source":34,"section":460},"8.1",{"level":462,"text":463,"quote":466,"refs":467},"avoid",{"fa":464,"en":465},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Alternatively, advise a woman that breastfeeding is not recommended during treatment with ciprofloxacin and for an additional two days (five half-lives) after the last dose.",[468],{"source":34,"section":469},"8.2",{"level":453,"text":471,"quote":474,"refs":475},{"fa":472,"en":473},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Complicated Urinary Tract Infection and Pyelonephritis Ciprofloxacin is indicated for the treatment of cUTI and pyelonephritis due to Escherichia coli in pediatric patients 1 to 17 years of age.",[476],{"source":34,"section":209},{"level":453,"text":478,"quote":481,"refs":482},{"fa":479,"en":480},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Caution should be used when prescribing ciprofloxacin to elderly patients especially those on corticosteroids.",[483],{"source":34,"section":484},"8.5",{"kind":486,"refs":487,"id":432},"ANDA",[488],{"source":34,"section":489},"SPL approval \u002F marketing category",1792191874019]