[{"data":1,"prerenderedAt":245},["ShallowReactive",2],{"drug-cisplatin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":16,"formulations":19,"regimens":34,"contraindications":94,"warnings":104,"renal":123,"monitoring":124,"interactions":125,"review":126,"examples":129,"atc":145,"iran":147,"usApproval":179,"links":185,"populations":202},"cisplatin",1,{"fa":7,"en":8},"سیس‌پلاتین","Cisplatin","antineoplastic-immunomodulating",{"fa":11,"en":12},"ترکیب پلاتین","Platinum compound",[14],{"name":8,"market":15},"US",[17,18,4],"platinol","سیسپلاتین",[20],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"vial-50","powder-for-injection","iv","50 mg vial",{"amount":26,"unit":27,"perUnit":28},50,"mg","vial",[15],[31],{"source":32,"section":33},"fda-cisplatin","3",[35,60,81],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":27,"dose":46,"refs":48,"durationDays":51,"notes":53},"testis","testicular-cancer",{"fa":39,"en":40},"سرطان پیشرفته بیضه — ۲۰ mg\u002Fm² وریدی روزانه ۵ روز در هر دوره","Advanced testicular cancer — 20 mg\u002Fm² IV daily for 5 days per cycle",{"minAge":42},{"value":43,"unit":44},18,"year","bsa",{"perM2PerDay":47,"dividedDoses":5},20,[49],{"source":32,"section":50},"2.2",{"min":52,"max":52},5,[54],{"text":55,"refs":58},{"fa":56,"en":57},"فقط زیر نظر پزشک متخصص شیمی‌درمانی و در مرکز مجهز. عدد ماشین‌حساب = mg\u002Fm² برچسب × سطح بدن (Mosteller)؛ پروتکل، فاصله دوره‌ها، تنظیم بر اساس CBC و عملکرد کلیه\u002Fکبد با تیم انکولوژی.","Only under an oncologist in an equipped centre. Calculator = label mg\u002Fm² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal\u002Fhepatic function rest with the oncology team.",[59],{"source":32,"section":50},{"id":61,"disease":62,"label":63,"population":66,"type":45,"unit":27,"dose":68,"refs":70,"durationDays":73,"notes":74},"ovary","ovarian-cancer",{"fa":64,"en":65},"سرطان پیشرفته تخمدان — ۷۵ تا ۱۰۰ mg\u002Fm² روز ۱ هر ۳ تا ۴ هفته","Advanced ovarian cancer — 75–100 mg\u002Fm² on day 1 every 3–4 weeks",{"minAge":67},{"value":43,"unit":44},{"perM2PerDay":69,"dividedDoses":5},75,[71],{"source":32,"section":72},"2.3",{"min":5,"max":5},[75],{"text":76,"refs":79},{"fa":77,"en":78},"عدد ماشین‌حساب حد پایین (۷۵ mg\u002Fm²) است.","Calculator gives the lower bound (75 mg\u002Fm²).",[80],{"source":32,"section":72},{"id":82,"disease":83,"label":84,"population":87,"type":45,"unit":27,"dose":89,"refs":90,"durationDays":93},"bladder","bladder-cancer",{"fa":85,"en":86},"سرطان پیشرفته مثانه — ۵۰ تا ۷۰ mg\u002Fm² هر ۳ تا ۴ هفته (درمان‌شده قبلی: ۵۰ mg\u002Fm² هر ۴ هفته)","Advanced bladder cancer — 50–70 mg\u002Fm² every 3–4 weeks (heavily pretreated: 50 mg\u002Fm² every 4 weeks)",{"minAge":88},{"value":43,"unit":44},{"perM2PerDay":26,"dividedDoses":5},[91],{"source":32,"section":92},"2.4",{"min":5,"max":5},[95],{"id":96,"severity":97,"text":98,"refs":101},"hyper","block",{"fa":99,"en":100},"حساسیت شدید به سیس‌پلاتین.","Severe hypersensitivity to cisplatin.",[102],{"source":32,"section":103},"4",[105,114],{"text":106,"refs":109},{"fa":107,"en":108},"هشدار جعبه‌ای: نفروتوکسیسیتی شدید (هیدراتاسیون کافی و پایش کلیه و الکترولیت)، نوروپاتی محیطی، تهوع و استفراغ شدید (ضدتهوع پیش و پس)، سرکوب مغز استخوان.","Boxed warning: severe nephrotoxicity (adequate hydration; monitor renal function and electrolytes), peripheral neuropathy, severe nausea\u002Fvomiting (antiemetics before and after), myelosuppression.",[110,112],{"source":32,"section":111},"Boxed Warning",{"source":32,"section":113},"2.1",{"text":115,"refs":118},{"fa":116,"en":117},"سمیت شنوایی؛ سمیت چشمی؛ حساسیت؛ بدخیمی ثانویه؛ سمیت جنینی. با وسایل آلومینیومی تماس نیابد.","Ototoxicity; ocular toxicity; hypersensitivity; secondary malignancy; embryo-fetal toxicity. Avoid aluminium equipment.",[119,121],{"source":32,"section":120},"5",{"source":32,"section":122},"2",[],[],[],{"status":127,"reviewer":128,"date":128},"unverified",null,[130,137,141],{"regimen":36,"formulation":21,"input":131,"expect":135},{"ageYears":132,"weightKg":133,"heightCm":134},55,80,180,{"perDose":136},40,{"regimen":61,"formulation":21,"input":138,"expect":139},{"ageYears":132,"weightKg":133,"heightCm":134},{"perDose":140},150,{"regimen":82,"formulation":21,"input":142,"expect":143},{"ageYears":132,"weightKg":133,"heightCm":134},{"perDose":144},100,[146],"L01XA01",{"status":148,"forms":149,"refs":174},"registered",[150,154,158,162,166,170],{"code":151,"en":152,"fa":153},"00302","CISPLATIN 0.5MG\u002FML 100ML INF","محلول انفوزیون سیس‌پلاتین ۰٫۵ میلی‌گرم \u002F میلی‌لیتر ۱۰۰ میلی‌لیتر",{"code":155,"en":156,"fa":157},"00301","CISPLATIN 0.5MG\u002FML 20ML INF","محلول انفوزیون سیس‌پلاتین ۰٫۵ میلی‌گرم \u002F میلی‌لیتر ۲۰ میلی‌لیتر",{"code":159,"en":160,"fa":161},"11867","CISPLATIN 10MG VIAL","ویال سیس‌پلاتین ۱۰ میلی‌گرم",{"code":163,"en":164,"fa":165},"11868","CISPLATIN 50MG VIAL","ویال سیس‌پلاتین ۵۰ میلی‌گرم",{"code":167,"en":168,"fa":169},"22226","CISPLATIN 50MG\u002F50ML SOLUTION FOR INJ","فرآورده تزریقی سیس‌پلاتین ۵۰ میلی‌گرم \u002F ۵۰ میلی‌لیتر",{"code":171,"en":172,"fa":173},"52347","CISPLATIN INJECTION, POWDER, FOR SOLUTION INTRAVENOUS 10 mg","پودر تزریقی سیس‌پلاتین ۱۰ میلی‌گرم",[175],{"source":176,"section":177,"url":178},"darooyab-generic","G-970\u002FCisplatin","https:\u002F\u002Fwww.darooyab.ir\u002FG-970\u002FCisplatin",{"kind":180,"refs":181,"id":184},"NDA",[182],{"source":32,"section":183},"SPL approval \u002F marketing category","NDA018057",[186,189,193,197,200],{"kind":187,"url":188,"label":184},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=018057",{"kind":190,"url":191,"label":192},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=508496cb-3441-46b3-a4fe-e0d440e6adc6","FDA Cisplatin",{"kind":194,"url":195,"label":196},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa684036.html","Cisplatin Injection",{"kind":198,"url":199,"label":146},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L01XA01",{"kind":201,"url":178,"label":8},"darooyab",{"pregnancy":203,"lactation":212,"pediatric":220,"geriatric":229,"reproductive":237},{"level":204,"text":205,"quote":208,"refs":209},"avoid",{"fa":206,"en":207},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary Based on human data from published literature, cisplatin for injection can cause fetal harm when administered to pregnant women.",[210],{"source":32,"section":211},"8.1",{"level":204,"text":213,"quote":216,"refs":217},{"fa":214,"en":215},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions from cisplatin for injection in a breastfed child and because of the potential for tumorigenicity shown for cisplatin for injection, advise lactating women not to breastfeed during treatment with cisplatin for injection.",[218],{"source":32,"section":219},"8.2",{"level":221,"text":222,"quote":225,"refs":226},"caution",{"fa":223,"en":224},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Ototoxic effects may be more severe and detrimental in pediatric patients receiving cisplatin for injection, particularly in patients less than 5 years of age.",[227],{"source":32,"section":228},"8.4",{"level":221,"text":230,"quote":233,"refs":234},{"fa":231,"en":232},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","… ptible to nephrotoxicity, myelosuppression, and infectious complications than are younger patients [see Warnings and Precautions ( 5.1 , 5.2 , 5.4 )].",[235],{"source":32,"section":236},"8.5",{"level":221,"text":238,"quote":241,"refs":242},{"fa":239,"en":240},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Females Cisplatin for injection can cause fetal harm when administered to a pregnant woman [see Use in Specific Populations ( 8.1 )] .",[243],{"source":32,"section":244},"8.3",1792444709716]