[{"data":1,"prerenderedAt":396},["ShallowReactive",2],{"drug-clarithromycin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":148,"warnings":199,"renal":242,"monitoring":252,"interactions":253,"review":254,"examples":257,"atc":285,"iran":287,"links":327,"populations":350,"usApproval":391},"clarithromycin",1,{"fa":7,"en":8},"کلاریترومایسین","Clarithromycin","anti-infectives",{"fa":11,"en":12},"ماکرولید","Macrolide",[14],{"name":15,"market":16},"Biaxin","US",[18,19],"clarithro","کلاریترو",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"susp-125-5","suspension","oral","125 mg \u002F 5 mL",{"amount":27,"unit":28,"perVolumeMl":29},125,"mg",5,[16],[32],{"source":33,"section":34},"fda-clarithromycin-susp","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"susp-250-5","250 mg \u002F 5 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اکتسابی","Community-acquired pneumonia",{"minAge":80},{"value":52,"unit":53},{"perKgPerDay":56,"dividedDoses":57},[83,84],{"source":33,"section":60},{"source":33,"section":62},{"maxPerDose":39,"refs":86},[87],{"source":66,"section":67,"note":88},{"fa":69,"en":70},{"min":72,"max":72},{"id":91,"disease":92,"label":93,"population":96,"type":54,"unit":28,"dose":98,"refs":99,"limits":102,"durationDays":109},"sinusitis","acute-bacterial-sinusitis",{"fa":94,"en":95},"سینوزیت ماگزیلاری حاد","Acute maxillary sinusitis",{"minAge":97},{"value":52,"unit":53},{"perKgPerDay":56,"dividedDoses":57},[100,101],{"source":33,"section":60},{"source":33,"section":62},{"maxPerDose":103,"refs":104},500,[105],{"source":66,"section":67,"note":106},{"fa":107,"en":108},"دوز بزرگسال این عفونت: 500 mg هر ۱۲ ساعت","Adult dose for this infection: 500 mg every 12 h (\"up to the adult dose\")",{"min":72,"max":72},{"id":111,"disease":112,"label":113,"population":116,"type":54,"unit":28,"dose":118,"refs":119,"limits":122,"durationDays":126},"skin","skin-soft-tissue-infection",{"fa":114,"en":115},"عفونت پوست بدون عارضه","Uncomplicated skin infection",{"minAge":117},{"value":52,"unit":53},{"perKgPerDay":56,"dividedDoses":57},[120,121],{"source":33,"section":60},{"source":33,"section":62},{"maxPerDose":39,"refs":123},[124],{"source":66,"section":67,"note":125},{"fa":69,"en":70},{"min":72,"max":72},{"id":128,"disease":129,"label":130,"population":133,"type":54,"unit":28,"dose":135,"refs":136,"durationDays":140,"notes":141},"aom","acute-otitis-media",{"fa":131,"en":132},"اوتیت مدیای حاد","Acute otitis media",{"minAge":134},{"value":52,"unit":53},{"perKgPerDay":56,"dividedDoses":57},[137,138],{"source":33,"section":60},{"source":33,"section":139},"1.6",{"min":72,"max":72},[142],{"text":143,"refs":146},{"fa":144,"en":145},"برچسب برای اوتیت مدیا دوز بزرگسال تعریف نکرده است؛ سقف «تا دوز بزرگسال» را با جدول بزرگسالان بسنجید.","The label defines no adult dose for otitis media; check \"up to the adult dose\" against the adult table.",[147],{"source":66,"section":67},[149,158,166,174,182,190],{"id":150,"severity":151,"text":152,"refs":155},"hypersensitivity","block",{"fa":153,"en":154},"حساسیت به کلاریترومایسین، اریترومایسین یا هر ماکرولید.","Hypersensitivity to clarithromycin, erythromycin or any macrolide.",[156],{"source":33,"section":157},"4.1",{"id":159,"severity":151,"text":160,"refs":163},"cisapride-pimozide",{"fa":161,"en":162},"مصرف همزمان با سیزاپراید یا پیموزاید (آریتمی کشنده).","Concomitant cisapride or pimozide (fatal arrhythmias).",[164],{"source":33,"section":165},"4.2",{"id":167,"severity":151,"text":168,"refs":171},"hepatic-history",{"fa":169,"en":170},"سابقه یرقان کلستاتیک\u002Fاختلال کبدی با کلاریترومایسین.","History of cholestatic jaundice\u002Fhepatic dysfunction with clarithromycin.",[172],{"source":33,"section":173},"4.3",{"id":175,"severity":151,"text":176,"refs":179},"colchicine",{"fa":177,"en":178},"همراه کلشی‌سین در نارسایی کلیه یا کبد.","With colchicine in renal or hepatic impairment.",[180],{"source":33,"section":181},"4.4",{"id":183,"severity":151,"text":184,"refs":187},"statins",{"fa":185,"en":186},"همراه لومیتاپید، لواستاتین یا سیمواستاتین.","With lomitapide, lovastatin or simvastatin.",[188],{"source":33,"section":189},"4.5",{"id":191,"severity":151,"rule":192,"text":194,"refs":197},"under-6-months",{"maxAge":193},{"value":52,"unit":53},{"fa":195,"en":196},"بی‌خطری سوسپانسیون زیر ۶ ماه ثابت نشده است.","Safety and effectiveness established only from 6 months.",[198],{"source":33,"section":62},[200,207,214,221,228,235],{"text":201,"refs":204},{"fa":202,"en":203},"واکنش‌های حساسیتی حاد شدید","Severe acute hypersensitivity reactions",[205],{"source":33,"section":206},"5.1",{"text":208,"refs":211},{"fa":209,"en":210},"طولانی شدن QT","QT 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50%.",[250],{"source":33,"section":251},"2.6",[],[],{"status":255,"reviewer":256,"date":256},"unverified",null,[258,263,268,273,277,280],{"regimen":45,"formulation":22,"input":259,"expect":260},{"ageYears":57,"weightKg":72},{"perDose":261,"mlPerDose":262},75,3,{"regimen":45,"formulation":36,"input":264,"expect":267},{"ageYears":265,"weightKg":266},12,40,{"perDose":39},{"regimen":74,"formulation":36,"input":269,"expect":271},{"ageYears":52,"weightKg":270},20,{"perDose":272},150,{"regimen":91,"formulation":36,"input":274,"expect":275},{"ageYears":72,"weightKg":266},{"perDose":276,"mlPerDose":52},300,{"regimen":111,"formulation":22,"input":278,"expect":279},{"ageYears":57,"weightKg":72},{"perDose":261},{"regimen":128,"formulation":22,"input":281,"expect":282},{"ageYears":57,"weightKg":265},{"perDose":283,"mlPerDose":284},90,3.6,[286],"J01FA09",{"status":288,"forms":289,"refs":322},"registered",[290,294,298,302,306,310,314,318],{"code":291,"en":292,"fa":293},"01838","CLARITHROMYCIN 125MG\u002F5ML SUSP","سوسپانسیون کلاریترومایسین ۱۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":295,"en":296,"fa":297},"01837","CLARITHROMYCIN 250MG TAB","قرص کلاریترومایسین ۲۵۰ میلی‌گرم",{"code":299,"en":300,"fa":301},"13464","CLARITHROMYCIN 250MG\u002F5ML 100ML SUSP","سوسپانسیون کلاریترومایسین ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۰۰ میلی‌لیتر",{"code":303,"en":304,"fa":305},"09300","CLARITHROMYCIN 250MG\u002F5ML 60ML SUSP","سوسپانسیون کلاریترومایسین ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۶۰ میلی‌لیتر",{"code":307,"en":308,"fa":309},"02034","CLARITHROMYCIN 500MG TAB","قرص کلاریترومایسین ۵۰۰ میلی‌گرم",{"code":311,"en":312,"fa":313},"50194","CLARITHROMYCIN GRANULE, FOR SUSPENSION ORAL 250 mg","سوسپانسیون خوراکی کلاریترومایسین ۲۵۰ میلی‌گرم",{"code":315,"en":316,"fa":317},"51903","CLARITHROMYCIN POWDER, FOR SUSPENSION ORAL 125 mg\u002F5 mL 60 mL","سوسپانسیون خوراکی کلاریترومایسین ۱۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۶۰ میلی‌لیتر",{"code":319,"en":320,"fa":321},"52002","CLARITHROMYCIN POWDER, FOR SUSPENSION ORAL 250 mg\u002F5 mL 100 mL","سوسپانسیون خوراکی کلاریترومایسین ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۰۰ میلی‌لیتر",[323],{"source":324,"section":325,"url":326},"darooyab-generic","G-362\u002FClarithromycin","https:\u002F\u002Fwww.darooyab.ir\u002FG-362\u002FClarithromycin",[328,332,336,339,342,345,348],{"kind":329,"url":330,"label":331},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=065283","ANDA065283",{"kind":333,"url":334,"label":335},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=22457862-0f88-4be8-b507-1c8f264269f2","FDA Clarithromycin susp",{"kind":333,"url":337,"label":338},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=25debd85-0840-4f8d-9898-027772061dd2","FDA Clarithromycin tab",{"kind":340,"url":341,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa692005.html",{"kind":340,"url":343,"label":344},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601067.html","Lansoprazole, Clarithromycin, and Amoxicillin",{"kind":346,"url":347,"label":286},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01FA09",{"kind":349,"url":326,"label":8},"darooyab",{"pregnancy":351,"lactation":360,"pediatric":368,"geriatric":375,"reproductive":383},{"level":352,"text":353,"quote":356,"refs":357},"caution",{"fa":354,"en":355},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Based on findings from animal studies, clarithromycin is not recommended for use in pregnant women except in clinical circumstances where no alternative therapy is appropriate.",[358],{"source":33,"section":359},"8.1",{"level":352,"text":361,"quote":364,"refs":365},{"fa":362,"en":363},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Based on limited human data, clarithromycin and its active metabolite 14-OH clarithromycin are present in human milk at less than 2% of the maternal weight-adjusted dose ( see Data ).",[366],{"source":33,"section":367},"8.2",{"level":352,"text":369,"quote":372,"refs":373},{"fa":370,"en":371},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of clarithromycin for oral suspension have been established for the treatment of the following conditions or diseases in pediatric patients 6 months and older.",[374],{"source":33,"section":62},{"level":352,"text":376,"quote":379,"refs":380},{"fa":377,"en":378},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Elderly patients may be more susceptible to development of torsades de pointes arrhythmias than younger patients [ see Warnings and Precautions ( 5.3 ) ].",[381],{"source":33,"section":382},"8.5",{"level":352,"text":384,"quote":387,"refs":388},{"fa":385,"en":386},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Males Administration of clarithromycin resulted in testicular atrophy in rats, dogs and monkeys [see Nonclinical Toxicology ( 13.1 )] .",[389],{"source":33,"section":390},"8.3",{"kind":392,"refs":393,"id":331},"ANDA",[394],{"source":33,"section":395},"SPL approval \u002F marketing category",1792440729948]