Clomipramine
کلومیپرامین
🧠 Nervous SystemTricyclic antidepressant
Market / country: 🇺🇸 USA
Anafranil (US)
🧮 Dose calculator
Obsessive-compulsive disorder · Regimen source: FDA Clomipramine · Dosage and Administration
- • To about 100 mg over 2 weeks (divided, with meals), then gradually to max 250 mg/day; after titration once at bedtime. FDA Clomipramine · Dosage and Administration
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Hypersensitivity to clomipramine or other TCAs; with or within 14 days of an MAOI; acute recovery period after MI. FDA Clomipramine · Contraindications
- ⚠️ Boxed warning: increased suicidal thoughts and behaviour in children, adolescents and young adults. FDA Clomipramine · Boxed Warning
Formulations
- 25 mg capsule — capsule 🇺🇸 USA FDA Clomipramine · How Supplied
- 50 mg capsule — capsule 🇺🇸 USA FDA Clomipramine · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Clomipramine · Pregnancy
“Clomipramine hydrochloride capsules, USP should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.”
- 🤱 BreastfeedingDangerous / avoid
Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Clomipramine · Nursing Mothers
“Because of the potential for adverse reactions, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.”
- 👶 ChildrenDangerous / avoid
Boxed warning in the label about children. FDA Clomipramine · Boxed Warning
“Clomipramine hydrochloride is not approved for use in pediatric patients except for patients with obsessive compulsive disorder (OCD) ( see WARNINGS, Clinical Worsening and Suicide Risk ;”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Clomipramine · Geriatric Use
“In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA211364
- DailyMed (FDA label)FDA Clomipramine
- MedlinePlus (NIH)Clomipramine
- WHO ATC/DDDN06AA04
- Darooyab (Iran)Clomipramine
🇮🇷 Registered in Iran Darooyab · G-577/Clomipramine
Dosage forms with Iranian generic codes, per Darooyab.
- 07402 · CLOMIPRAMINE HCL 10MG CAP · کپسول کلومیپرامین هیدروکلراید ۱۰ میلیگرم
- 00320 · CLOMIPRAMINE HCL 10MG TAB · قرص کلومیپرامین هیدروکلراید ۱۰ میلیگرم
- 07080 · CLOMIPRAMINE HCL 25MG CAP · کپسول کلومیپرامین هیدروکلراید ۲۵ میلیگرم
- 00321 · CLOMIPRAMINE HCL 25MG TAB · قرص کلومیپرامین هیدروکلراید ۲۵ میلیگرم
- 07949 · CLOMIPRAMINE HCL 25MG/2ML AMP · آمپول کلومیپرامین هیدروکلراید ۲۵ میلیگرم / ۲ میلیلیتر
- 01438 · CLOMIPRAMINE HCL 50MG TAB · قرص کلومیپرامین هیدروکلراید ۵۰ میلیگرم
- 01439 · CLOMIPRAMINE HCL 75MG TAB · قرص کلومیپرامین هیدروکلراید ۷۵ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Clomipramine · How SuppliedFDA Clomipramine · Dosage and AdministrationFDA Clomipramine · ContraindicationsFDA Clomipramine · Boxed WarningFDA Clomipramine · PregnancyFDA Clomipramine · Nursing MothersFDA Clomipramine · Geriatric UseFDA Clomipramine · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-577/Clomipramine
- Clinical review⚠ Unverified