[{"data":1,"prerenderedAt":369},["ShallowReactive",2],{"drug-co-trimoxazole":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":19,"formulations":25,"regimens":50,"contraindications":199,"warnings":225,"renal":226,"monitoring":241,"interactions":242,"review":243,"examples":246,"atc":278,"iran":280,"links":308,"populations":329,"usApproval":364},"co-trimoxazole",1,{"fa":7,"en":8},"کوتریموکسازول (سولفامتوکسازول\u002Fتری‌متوپریم)","Sulfamethoxazole-trimethoprim (co-trimoxazole)","anti-infectives",{"fa":11,"en":12},"سولفونامید + مهارکننده دی‌هیدروفولات ردوکتاز","Sulfonamide + dihydrofolate reductase inhibitor",[14,17],{"name":15,"market":16},"Bactrim","US",{"name":18,"market":16},"Septra",[20,21,22,23,24],"TMP-SMX","cotrimoxazole","باکتریم","سپترین","کوتریموکسازول",[26],{"id":27,"form":28,"route":29,"label":30,"concentration":31,"markets":35,"refs":36,"components":40},"susp-40-200","suspension","oral","TMP 40 mg + SMX 200 mg \u002F 5 mL",{"amount":32,"unit":33,"perVolumeMl":34},40,"mg",5,[16],[37],{"source":38,"section":39},"fda-tmp-smx-susp","How Supplied",{"trimethoprim":41,"sulfamethoxazole":45},{"name":42,"amount":32,"unit":33},{"fa":43,"en":44},"تری‌متوپریم","Trimethoprim",{"name":46,"amount":49,"unit":33},{"fa":47,"en":48},"سولفامتوکسازول","Sulfamethoxazole",200,[51,84,113,133,155,182],{"id":52,"disease":53,"label":54,"population":57,"type":61,"unit":33,"dose":62,"refs":64,"doseComponent":67,"limits":68,"durationDays":75,"notes":77},"uti","urinary-tract-infection",{"fa":55,"en":56},"عفونت ادراری — تری‌متوپریم ۸ mg\u002Fkg\u002Fday هر ۱۲ ساعت، ۱۰ روز","UTI — TMP 8 mg\u002Fkg\u002Fday every 12 h, 10 days",{"minAge":58},{"value":59,"unit":60},2,"month","weightBased",{"perKgPerDay":63,"dividedDoses":59},8,[65],{"source":38,"section":66},"Dosage and Administration","trimethoprim",{"maxPerDose":69,"refs":70},160,[71],{"source":38,"section":66,"note":72},{"fa":73,"en":74},"دوز بزرگسال ۲۰ mL (تری‌متوپریم ۱۶۰ mg) هر ۱۲ ساعت","Adult dose 20 mL (TMP 160 mg) every 12 h; table: 40 kg → 20 mL",{"min":76,"max":76},10,[78],{"text":79,"refs":82},{"fa":80,"en":81},"دوز بر اساس جزء تری‌متوپریم محاسبه و نمایش داده می‌شود.","Dose is calculated and shown as the trimethoprim component.",[83],{"source":38,"section":66},{"id":85,"disease":86,"label":87,"population":90,"type":61,"unit":33,"dose":92,"refs":93,"doseComponent":67,"limits":97,"durationDays":101,"notes":102},"aom","acute-otitis-media",{"fa":88,"en":89},"اوتیت مدیای حاد — تری‌متوپریم ۸ mg\u002Fkg\u002Fday هر ۱۲ ساعت، ۱۰ روز","Acute otitis media — TMP 8 mg\u002Fkg\u002Fday every 12 h, 10 days",{"minAge":91},{"value":59,"unit":60},{"perKgPerDay":63,"dividedDoses":59},[94,95],{"source":38,"section":66},{"source":38,"section":96},"Indications and Usage",{"maxPerDose":69,"refs":98},[99],{"source":38,"section":66,"note":100},{"fa":73,"en":74},{"min":76,"max":76},[103,107],{"text":104,"refs":105},{"fa":80,"en":81},[106],{"source":38,"section":66},{"text":108,"refs":111},{"fa":109,"en":110},"برای پیشگیری یا مصرف طولانی در اوتیت مدیا اندیکاسیون ندارد؛ داده بی‌خطری مصرف مکرر زیر ۲ سال محدود است.","Not indicated for prophylactic or prolonged use in otitis media; limited safety data for repeated use under 2 years.",[112],{"source":38,"section":96},{"id":114,"disease":114,"label":115,"population":118,"type":61,"unit":33,"dose":120,"refs":121,"doseComponent":67,"limits":123,"durationDays":127,"notes":128},"shigellosis",{"fa":116,"en":117},"شیگلوز — تری‌متوپریم ۸ mg\u002Fkg\u002Fday هر ۱۲ ساعت، ۵ روز","Shigellosis — TMP 8 mg\u002Fkg\u002Fday every 12 h, 5 days",{"minAge":119},{"value":59,"unit":60},{"perKgPerDay":63,"dividedDoses":59},[122],{"source":38,"section":66},{"maxPerDose":69,"refs":124},[125],{"source":38,"section":66,"note":126},{"fa":73,"en":74},{"min":34,"max":34},[129],{"text":130,"refs":131},{"fa":80,"en":81},[132],{"source":38,"section":66},{"id":134,"disease":135,"label":136,"population":139,"type":61,"unit":33,"dose":141,"refs":145,"doseComponent":67,"durationDays":147,"notes":150},"pcp-treatment","pneumocystis-pneumonia",{"fa":137,"en":138},"درمان PCP — تری‌متوپریم ۱۵ تا ۲۰ mg\u002Fkg\u002Fday هر ۶ ساعت","PCP treatment — TMP 15–20 mg\u002Fkg\u002Fday every 6 h",{"minAge":140},{"value":59,"unit":60},{"perKgPerDay":142,"perKgPerDayMax":143,"dividedDoses":144},15,20,4,[146],{"source":38,"section":66},{"min":148,"max":149},14,21,[151],{"text":152,"refs":153},{"fa":80,"en":81},[154],{"source":38,"section":66},{"id":156,"disease":135,"label":157,"population":160,"type":165,"unit":33,"dose":166,"refs":168,"doseComponent":67,"limits":170,"notes":177},"pcp-prophylaxis-child",{"fa":158,"en":159},"پیشگیری PCP کودکان — تری‌متوپریم ۱۵۰ mg\u002Fm²\u002Fday در دو نوبت، ۳ روز متوالی در هفته","PCP prophylaxis, children — TMP 150 mg\u002Fm²\u002Fday in 2 doses, 3 consecutive days\u002Fweek",{"minAge":161,"maxAge":162},{"value":59,"unit":60},{"value":163,"unit":164},18,"year","bsa",{"perM2PerDay":167,"dividedDoses":59},150,[169],{"source":38,"section":66},{"maxPerDay":171,"refs":172},320,[173],{"source":38,"section":66,"note":174},{"fa":175,"en":176},"کل دوز روزانه نباید از ۳۲۰ mg تری‌متوپریم بیشتر شود","Total daily dose should not exceed 320 mg TMP",[178],{"text":179,"refs":180},{"fa":80,"en":81},[181],{"source":38,"section":66},{"id":183,"disease":53,"label":184,"population":187,"type":189,"unit":33,"dose":190,"refs":191,"doseComponent":67,"durationDays":193,"notes":194},"adult-uti",{"fa":185,"en":186},"بزرگسال — ۲۰ mL (تری‌متوپریم ۱۶۰ mg) هر ۱۲ ساعت","Adults — 20 mL (TMP 160 mg) every 12 h",{"minAge":188},{"value":163,"unit":164},"fixed",{"perDose":69,"dosesPerDay":59},[192],{"source":38,"section":66},{"min":76,"max":148},[195],{"text":196,"refs":197},{"fa":80,"en":81},[198],{"source":38,"section":66},[200,209,218],{"id":201,"severity":202,"text":203,"refs":206},"hypersensitivity","block",{"fa":204,"en":205},"حساسیت به تری‌متوپریم یا سولفونامیدها.","Known hypersensitivity to trimethoprim or sulfonamides.",[207],{"source":38,"section":208},"Contraindications",{"id":210,"severity":202,"rule":211,"text":213,"refs":216},"under-2-months",{"maxAge":212},{"value":59,"unit":60},{"fa":214,"en":215},"کودکان کمتر از ۲ ماه.","Pediatric patients less than 2 months of age.",[217],{"source":38,"section":208},{"id":219,"severity":202,"text":220,"refs":223},"other",{"fa":221,"en":222},"سابقه ترومبوسیتوپنی ایمنی ناشی از دارو، کم‌خونی مگالوبلاستیک ناشی از کمبود فولات، آسیب شدید کبدی، نارسایی شدید کلیه بدون امکان پایش، مصرف همزمان دوفتیلید.","History of drug-induced immune thrombocytopenia, folate-deficiency megaloblastic anemia, marked hepatic damage, severe renal insufficiency without monitoring, concomitant dofetilide.",[224],{"source":38,"section":208},[],[227,235],{"egfrBelow":228,"severity":229,"text":230,"refs":233},30,"warn",{"fa":231,"en":232},"کلیرانس ۱۵ تا ۳۰: نصف رژیم معمول.","CrCl 15–30 mL\u002Fmin: half the usual regimen.",[234],{"source":38,"section":66},{"egfrBelow":142,"severity":202,"text":236,"refs":239},{"fa":237,"en":238},"کلیرانس کمتر از ۱۵: مصرف توصیه نمی‌شود.","CrCl below 15 mL\u002Fmin: use not recommended.",[240],{"source":38,"section":66},[],[],{"status":244,"reviewer":245,"date":245},"unverified",null,[247,250,254,258,261,264,270,274],{"regimen":52,"formulation":27,"input":248,"expect":249},{"ageYears":59,"weightKg":76},{"perDose":32,"mlPerDose":34},{"regimen":52,"formulation":27,"input":251,"expect":253},{"ageYears":252,"weightKg":32},12,{"perDose":69,"mlPerDose":143},{"regimen":85,"formulation":27,"input":255,"expect":256},{"ageYears":34,"weightKg":143},{"perDose":257,"mlPerDose":76},80,{"regimen":114,"formulation":27,"input":259,"expect":260},{"ageYears":34,"weightKg":143},{"perDose":257},{"regimen":134,"formulation":27,"input":262,"expect":263},{"ageYears":5,"weightKg":63},{"perDose":228,"upperPerDose":32,"upperMlPerDose":34},{"regimen":156,"formulation":27,"input":265,"expect":268},{"ageYears":34,"weightKg":266,"heightCm":267},16,100,{"perDay":267,"perDose":269},50,{"regimen":183,"formulation":27,"input":271,"expect":273},{"ageYears":228,"weightKg":272},70,{"perDose":69,"mlPerDose":143},{"regimen":52,"formulation":27,"input":275,"expect":276},{"ageDays":228,"weightKg":144},{"status":277},"blocked",[279],"J01EE01",{"status":281,"forms":282,"refs":303},"registered",[283,287,291,295,299],{"code":284,"en":285,"fa":286},"00342","CO TRIMOXAZOLE 100\u002F20MG TAB","قرص کو تری‌متوپریم \u002F سولفامتوکسازول ۱۰۰ \u002F ۲۰ میلی‌گرم",{"code":288,"en":289,"fa":290},"00340","CO TRIMOXAZOLE 200\u002F40 MG\u002F5ML 100ML SUSP","سوسپانسیون کو تری‌متوپریم \u002F سولفامتوکسازول ۲۰۰ \u002F ۴۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۰۰ میلی‌لیتر",{"code":292,"en":293,"fa":294},"00339","CO TRIMOXAZOLE 400\u002F80 MG TAB","قرص کو تری‌متوپریم \u002F سولفامتوکسازول ۴۰۰ \u002F ۸۰ میلی‌گرم",{"code":296,"en":297,"fa":298},"00341","CO TRIMOXAZOLE 400\u002F80 MG\u002F5ML AMP","آمپول کو تری‌متوپریم \u002F سولفامتوکسازول ۴۰۰ \u002F ۸۰ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":300,"en":301,"fa":302},"05526","CO TRIMOXAZOLE 800\u002F160 MG TAB","قرص کو تری‌متوپریم \u002F سولفامتوکسازول ۸۰۰ \u002F ۱۶۰ میلی‌گرم",[304],{"source":305,"section":306,"url":307},"darooyab-generic","G-375\u002FCo-trimoxazole","https:\u002F\u002Fwww.darooyab.ir\u002FG-375\u002FCo-trimoxazole",[309,313,317,321,324,327],{"kind":310,"url":311,"label":312},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=214330","ANDA214330",{"kind":314,"url":315,"label":316},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=5ff03694-787a-409d-a95e-8422aa27499c","FDA TMP-SMX susp",{"kind":318,"url":319,"label":320},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa684026.html","Co-trimoxazole",{"kind":318,"url":322,"label":323},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601165.html","Co-trimoxazole Injection",{"kind":325,"url":326,"label":279},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01EE01",{"kind":328,"url":307,"label":320},"darooyab",{"pregnancy":330,"lactation":339,"pediatric":347,"geriatric":356},{"level":331,"text":332,"quote":335,"refs":336},"caution",{"fa":333,"en":334},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Because sulfamethoxazole and trimethoprim may interfere with folic acid metabolism, sulfamethoxazole and trimethoprim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.",[337],{"source":38,"section":338},"PREGNANCY",{"level":331,"text":340,"quote":343,"refs":344},{"fa":341,"en":342},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution should be exercised when sulfamethoxazole and trimethoprim is administered to a nursing woman, especially when breastfeeding, jaundiced, ill, stressed, or premature infants because of the potential risk of bilirubin displacement and kernicterus.",[345],{"source":38,"section":346},"NURSING MOTHERS",{"level":348,"text":349,"quote":352,"refs":353},"contraindicated",{"fa":350,"en":351},"برچسب: در کودکان زیر سن مشخص منع مصرف دارد.","Label: contraindicated in children below a stated age.","… ombocytopenia with use of trimethoprim and\u002For sulfonamides • documented megaloblastic anemia due to folate deficiency • pediatric patients less than 2 months of age • marked hepatic damage • severe renal insufficiency when renal function status cannot be monitored • concomitant administration with dofetilide (see …",[354],{"source":38,"section":355},"CONTRAINDICATIONS",{"level":331,"text":357,"quote":360,"refs":361},{"fa":358,"en":359},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","There may be an increased risk of severe adverse reactions in elderly patients, particularly when complicating conditions exist, e.g., impaired kidney and\u002For liver function, possible folate deficiency, or concomitant use of other drugs.",[362],{"source":38,"section":363},"GERIATRIC USE",{"kind":365,"refs":366,"id":312},"ANDA",[367],{"source":38,"section":368},"SPL approval \u002F marketing category",1792191874292]