[{"data":1,"prerenderedAt":258},["ShallowReactive",2],{"drug-diazepam-rectal":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":38,"contraindications":108,"warnings":138,"renal":139,"monitoring":140,"interactions":141,"review":142,"examples":145,"atc":162,"iran":164,"links":216,"populations":235,"usApproval":253},"diazepam-rectal",1,{"fa":7,"en":8},"ژل رکتال دیازپام","Diazepam rectal gel","nervous-system",{"fa":11,"en":12},"بنزودیازپین (ضدتشنج اورژانسی)","Benzodiazepine (rescue anticonvulsant)",[14],{"name":15,"market":16},"Diastat","US",[18,19,20,21],"diastat","دیازپام رکتال","شیاف دیازپام","تشنج تب",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":31,"refs":32},"gel-5","gel","rectal","5 mg\u002FmL rectal gel (unit doses 2.5–20 mg)",{"amount":29,"unit":30,"perVolumeMl":5},5,"mg",[16],[33,36],{"source":34,"section":35},"fda-diastat","Description",{"source":34,"section":37},"How Supplied",[39,68,89],{"id":40,"disease":41,"label":42,"population":45,"type":51,"unit":30,"dose":52,"refs":54,"limits":57,"notes":61},"2-5","status-epilepticus",{"fa":43,"en":44},"تشنج خوشه‌ای — ۲ تا ۵ سال: ۰٫۵ mg\u002Fkg رکتال","Acute repetitive seizures — 2–5 y: 0.5 mg\u002Fkg rectal",{"minAge":46,"maxAge":49},{"value":47,"unit":48},2,"year",{"value":50,"unit":48},6,"weightBased",{"perKgPerDay":53,"dividedDoses":5},0.5,[55],{"source":34,"section":56},"Dosage and Administration",{"maxPerDose":58,"refs":59},20,[60],{"source":34,"section":56},[62],{"text":63,"refs":66},{"fa":64,"en":65},"به نزدیک‌ترین دوز واحد بالاتر (۵، ۷٫۵، ۱۰، ۱۲٫۵، ۱۵، ۱۷٫۵، ۲۰ mg) گرد شود. حداکثر ۲۰ mg (سقف واحد موجود؛ برداشت Doz).","Round up to the next available unit dose (5, 7.5, 10, 12.5, 15, 17.5, 20 mg). Max 20 mg (largest unit dose; Doz derivation).",[67],{"source":34,"section":56},{"id":69,"disease":41,"label":70,"population":73,"type":51,"unit":30,"dose":77,"refs":79,"limits":81,"notes":84},"6-11",{"fa":71,"en":72},"تشنج خوشه‌ای — ۶ تا ۱۱ سال: ۰٫۳ mg\u002Fkg رکتال","Acute repetitive seizures — 6–11 y: 0.3 mg\u002Fkg rectal",{"minAge":74,"maxAge":75},{"value":50,"unit":48},{"value":76,"unit":48},12,{"perKgPerDay":78,"dividedDoses":5},0.3,[80],{"source":34,"section":56},{"maxPerDose":58,"refs":82},[83],{"source":34,"section":56},[85],{"text":86,"refs":87},{"fa":64,"en":65},[88],{"source":34,"section":56},{"id":90,"disease":41,"label":91,"population":94,"type":51,"unit":30,"dose":96,"refs":98,"limits":100,"notes":103},"12-plus",{"fa":92,"en":93},"تشنج خوشه‌ای — ۱۲ سال به بالا: ۰٫۲ mg\u002Fkg رکتال","Acute repetitive seizures — ≥12 y: 0.2 mg\u002Fkg rectal",{"minAge":95},{"value":76,"unit":48},{"perKgPerDay":97,"dividedDoses":5},0.2,[99],{"source":34,"section":56},{"maxPerDose":58,"refs":101},[102],{"source":34,"section":56},[104],{"text":105,"refs":106},{"fa":64,"en":65},[107],{"source":34,"section":56},[109,118,129],{"id":110,"severity":111,"text":112,"refs":115},"ci","block",{"fa":113,"en":114},"حساسیت به دیازپام؛ گلوکوم زاویه بسته حاد.","Hypersensitivity to diazepam; acute narrow-angle glaucoma.",[116],{"source":34,"section":117},"Contraindications",{"id":119,"severity":111,"rule":120,"text":123,"refs":126},"under-6m",{"maxAge":121},{"value":50,"unit":122},"month",{"fa":124,"en":125},"زیر ۶ ماه توصیه نمی‌شود.","Not recommended under 6 months.",[127],{"source":34,"section":128},"Warnings",{"id":130,"severity":131,"text":132,"refs":135},"boxed","warn",{"fa":133,"en":134},"هشدار جعبه‌ای: با اپیوئیدها دپرسیون تنفسی و مرگ؛ سوءمصرف و وابستگی.","Boxed warning: with opioids respiratory depression and death; abuse and dependence.",[136],{"source":34,"section":137},"Boxed Warning",[],[],[],[],{"status":143,"reviewer":144,"date":144},"unverified",null,[146,153,158],{"regimen":40,"formulation":24,"input":147,"expect":150},{"ageYears":148,"weightKg":149},3,15,{"perDose":151,"mlPerDose":152},7.5,1.5,{"regimen":69,"formulation":24,"input":154,"expect":157},{"ageYears":155,"weightKg":156},8,25,{"perDose":151},{"regimen":90,"formulation":24,"input":159,"expect":161},{"ageYears":58,"weightKg":160},60,{"perDose":76},[163],"N05BA01",{"status":165,"forms":166,"refs":211},"registered",[167,171,175,179,183,187,191,195,199,203,207],{"code":168,"en":169,"fa":170},"02237","DIAZEPAM 10MG RECTAL TUBE","دیازپام ۱۰ میلی‌گرم توب",{"code":172,"en":173,"fa":174},"01461","DIAZEPAM 10MG SUPP","شیاف دیازپام ۱۰ میلی‌گرم",{"code":176,"en":177,"fa":178},"00417","DIAZEPAM 10MG TAB","قرص دیازپام ۱۰ میلی‌گرم",{"code":180,"en":181,"fa":182},"00418","DIAZEPAM 10MG\u002F2ML AMP","آمپول دیازپام ۱۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":184,"en":185,"fa":186},"00419","DIAZEPAM 2MG TAB","قرص دیازپام ۲ میلی‌گرم",{"code":188,"en":189,"fa":190},"07051","DIAZEPAM 2MG\u002F5ML 120ML SYRUP","شربت دیازپام ۲ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":192,"en":193,"fa":194},"01462","DIAZEPAM 2MG\u002F5ML 60ML SYRUP","شربت دیازپام ۲ میلی‌گرم \u002F ۵ میلی‌لیتر ۶۰ میلی‌لیتر",{"code":196,"en":197,"fa":198},"02247","DIAZEPAM 5MG RECTAL TUBE","دیازپام ۵ میلی‌گرم توب",{"code":200,"en":201,"fa":202},"01460","DIAZEPAM 5MG SUPP","شیاف دیازپام ۵ میلی‌گرم",{"code":204,"en":205,"fa":206},"00420","DIAZEPAM 5MG TAB","قرص دیازپام ۵ میلی‌گرم",{"code":208,"en":209,"fa":210},"52452","DIAZEPAM SOLUTION ORAL 2 mg\u002F5 mL 120 mL","محلول خوراکی دیازپام ۲ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",[212],{"source":213,"section":214,"url":215},"darooyab-generic","G-1266\u002FDiazepam","https:\u002F\u002Fwww.darooyab.ir\u002FG-1266\u002FDiazepam",[217,221,225,229,232],{"kind":218,"url":219,"label":220},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=217468","ANDA217468",{"kind":222,"url":223,"label":224},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=b5b17a28-2cab-4c0d-8f9d-7b224e4d0989","FDA Diazepam rectal gel",{"kind":226,"url":227,"label":228},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa605033.html","Diazepam Rectal",{"kind":230,"url":231,"label":163},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05BA01",{"kind":233,"url":215,"label":234},"darooyab","Diazepam",{"pregnancy":236,"lactation":245},{"level":237,"text":238,"quote":241,"refs":242},"caution",{"fa":239,"en":240},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Neonates born to mothers using benzodiazepines late in pregnancy have been reported to experience symptoms of sedation and\u002For neonatal withdrawal (see WARNINGS: Neonatal Sedation and Withdrawal Syndrome and PRECAUTIONS: Pregnancy , Clinical Considerations).",[243],{"source":34,"section":244},"Pregnancy",{"level":237,"text":246,"quote":249,"refs":250},{"fa":247,"en":248},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution in Renally Impaired Patients Metabolites of diazepam rectal gel are excreted by the kidneys; to avoid their excess accumulation, caution should be exercised in the administration of the drug to patients with impaired renal function.",[251],{"source":34,"section":252},"Nursing Mothers",{"kind":254,"refs":255,"id":220},"ANDA",[256],{"source":34,"section":257},"SPL approval \u002F marketing category",1792191878841]