[{"data":1,"prerenderedAt":295},["ShallowReactive",2],{"drug-diazepam":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":52,"contraindications":125,"warnings":153,"renal":154,"monitoring":155,"interactions":156,"review":157,"examples":160,"atc":180,"iran":182,"links":234,"populations":254,"usApproval":290},"diazepam",1,{"fa":7,"en":8},"دیازپام","Diazepam","nervous-system",{"fa":11,"en":12},"بنزودیازپین","Benzodiazepine",[14],{"name":15,"market":16},"Valium","US",[18,19,7,20],"valium","والیوم","دیازپام ۵",[22,36,44],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-2","tablet","oral","2 mg tablet (scored)",{"amount":28,"unit":29,"perUnit":24,"scored":30},2,"mg",true,[16],[33],{"source":34,"section":35},"fda-diazepam","How Supplied",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-5","5 mg tablet (scored)",{"amount":40,"unit":29,"perUnit":24,"scored":30},5,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-10","10 mg tablet (scored)",{"amount":48,"unit":29,"perUnit":24,"scored":30},10,[16],[51],{"source":34,"section":35},[53,74,93,104],{"id":54,"disease":54,"label":55,"population":58,"type":62,"unit":29,"dose":63,"refs":64,"notes":67},"anxiety",{"fa":56,"en":57},"اضطراب — بزرگسال: ۲ تا ۱۰ mg دو تا چهار بار در روز","Anxiety — adults: 2–10 mg two to four times daily",{"minAge":59},{"value":60,"unit":61},18,"year","fixed",{"perDose":28,"perDoseMax":48,"dosesPerDay":28},[65],{"source":34,"section":66},"Dosage and Administration",[68],{"text":69,"refs":72},{"fa":70,"en":71},"بسته به شدت. سالمند\u002Fناتوان: ۲ تا ۲٫۵ mg یک یا دو بار و افزایش تدریجی.","By severity. Elderly\u002Fdebilitated: 2–2.5 mg once or twice daily, increase gradually.",[73],{"source":34,"section":66},{"id":75,"disease":76,"label":77,"population":80,"type":62,"unit":29,"dose":82,"refs":84,"notes":86},"alcohol","alcohol-withdrawal",{"fa":78,"en":79},"ترک حاد الکل: ۱۰ mg سه یا چهار بار در ۲۴ ساعت اول","Acute alcohol withdrawal: 10 mg 3–4 times in the first 24 h",{"minAge":81},{"value":60,"unit":61},{"perDose":48,"dosesPerDay":83},3,[85],{"source":34,"section":66},[87],{"text":88,"refs":91},{"fa":89,"en":90},"سپس ۵ mg سه یا چهار بار در روز در صورت نیاز.","Then 5 mg 3–4 times daily as needed.",[92],{"source":34,"section":66},{"id":94,"disease":95,"label":96,"population":99,"type":62,"unit":29,"dose":101,"refs":102},"spasm","muscle-spasm",{"fa":97,"en":98},"اسپاسم عضلانی (کمکی): ۲ تا ۱۰ mg سه یا چهار بار","Muscle spasm (adjunct): 2–10 mg 3–4 times daily",{"minAge":100},{"value":60,"unit":61},{"perDose":28,"perDoseMax":48,"dosesPerDay":83},[103],{"source":34,"section":66},{"id":105,"disease":54,"label":106,"population":109,"type":62,"unit":29,"dose":114,"refs":116,"notes":118},"peds",{"fa":107,"en":108},"کودکان ۶ ماه به بالا: ۱ تا ۲٫۵ mg سه یا چهار بار","Children ≥6 months: 1–2.5 mg 3–4 times daily",{"minAge":110,"maxAge":113},{"value":111,"unit":112},6,"month",{"value":60,"unit":61},{"perDose":5,"perDoseMax":115,"dosesPerDay":83},2.5,[117],{"source":34,"section":66},[119],{"text":120,"refs":123},{"fa":121,"en":122},"از کمترین دوز شروع و در صورت نیاز افزایش.","Start with the lowest dose and increase as required.",[124],{"source":34,"section":66},[126,137,144],{"id":127,"severity":128,"rule":129,"text":131,"refs":134},"under-6m","block",{"maxAge":130},{"value":111,"unit":112},{"fa":132,"en":133},"زیر ۶ ماه منع مصرف دارد.","Contraindicated under 6 months.",[135],{"source":34,"section":136},"Contraindications",{"id":138,"severity":128,"text":139,"refs":142},"ci",{"fa":140,"en":141},"حساسیت؛ میاستنی گراویس؛ نارسایی تنفسی شدید؛ نارسایی کبدی شدید؛ آپنه خواب؛ گلوکوم زاویه بسته حاد.","Hypersensitivity; myasthenia gravis; severe respiratory insufficiency; severe hepatic insufficiency; sleep apnoea; acute narrow-angle glaucoma.",[143],{"source":34,"section":136},{"id":145,"severity":146,"text":147,"refs":150},"boxed","warn",{"fa":148,"en":149},"هشدار جعبه‌ای: مصرف همزمان با اپیوئیدها (دپرسیون تنفسی و مرگ)؛ سوءمصرف و وابستگی؛ علائم ترک با قطع ناگهانی.","Boxed warning: concomitant opioids (respiratory depression, death); abuse, misuse and dependence; withdrawal on abrupt stop.",[151],{"source":34,"section":152},"Boxed Warning",[],[],[],[],{"status":158,"reviewer":159,"date":159},"unverified",null,[161,166,171,176],{"regimen":54,"formulation":23,"input":162,"expect":165},{"ageYears":163,"weightKg":164},35,70,{"perDose":28,"upperPerDose":48},{"regimen":75,"formulation":45,"input":167,"expect":170},{"ageYears":168,"weightKg":169},45,80,{"perDose":48},{"regimen":94,"formulation":23,"input":172,"expect":175},{"ageYears":173,"weightKg":174},40,75,{"perDose":28},{"regimen":105,"formulation":23,"input":177,"expect":178},{"ageYears":40,"weightKg":60},{"perDose":5,"tabletsPerDoseRounded":179},0.5,[181],"N05BA01",{"status":183,"forms":184,"refs":229},"registered",[185,189,193,197,201,205,209,213,217,221,225],{"code":186,"en":187,"fa":188},"02237","DIAZEPAM 10MG RECTAL TUBE","دیازپام ۱۰ میلی‌گرم توب",{"code":190,"en":191,"fa":192},"01461","DIAZEPAM 10MG SUPP","شیاف دیازپام ۱۰ میلی‌گرم",{"code":194,"en":195,"fa":196},"00417","DIAZEPAM 10MG TAB","قرص دیازپام ۱۰ میلی‌گرم",{"code":198,"en":199,"fa":200},"00418","DIAZEPAM 10MG\u002F2ML AMP","آمپول دیازپام ۱۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":202,"en":203,"fa":204},"00419","DIAZEPAM 2MG TAB","قرص دیازپام ۲ میلی‌گرم",{"code":206,"en":207,"fa":208},"07051","DIAZEPAM 2MG\u002F5ML 120ML SYRUP","شربت دیازپام ۲ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":210,"en":211,"fa":212},"01462","DIAZEPAM 2MG\u002F5ML 60ML SYRUP","شربت دیازپام ۲ میلی‌گرم \u002F ۵ میلی‌لیتر ۶۰ میلی‌لیتر",{"code":214,"en":215,"fa":216},"02247","DIAZEPAM 5MG RECTAL TUBE","دیازپام ۵ میلی‌گرم توب",{"code":218,"en":219,"fa":220},"01460","DIAZEPAM 5MG SUPP","شیاف دیازپام ۵ میلی‌گرم",{"code":222,"en":223,"fa":224},"00420","DIAZEPAM 5MG TAB","قرص دیازپام ۵ میلی‌گرم",{"code":226,"en":227,"fa":228},"52452","DIAZEPAM SOLUTION ORAL 2 mg\u002F5 mL 120 mL","محلول خوراکی دیازپام ۲ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",[230],{"source":231,"section":232,"url":233},"darooyab-generic","G-1266\u002FDiazepam","https:\u002F\u002Fwww.darooyab.ir\u002FG-1266\u002FDiazepam",[235,239,243,246,249,252],{"kind":236,"url":237,"label":238},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=070325","ANDA070325",{"kind":240,"url":241,"label":242},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=c397a9da-862f-4f3f-8109-7d21691de53a","FDA Diazepam",{"kind":244,"url":245,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682047.html",{"kind":244,"url":247,"label":248},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa624027.html","Diazepam Buccal",{"kind":250,"url":251,"label":181},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05BA01",{"kind":253,"url":233,"label":8},"darooyab",{"pregnancy":255,"lactation":264,"pediatric":273,"geriatric":282},{"level":256,"text":257,"quote":260,"refs":261},"caution",{"fa":258,"en":259},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Advise pregnant females that use of diazepam tablets late in pregnancy can result in sedation (respiratory depression, lethargy, hypotonia) and\u002For withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in newborns (see WARNINGS: Neonatal Sedation and …",[262],{"source":34,"section":263},"Pregnancy",{"level":265,"text":266,"quote":269,"refs":270},"avoid",{"fa":267,"en":268},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reaction, including sedation and withdrawal symptoms in breastfed infants, advise patient that breastfeeding is not recommended during treatment with diazepam tablets.",[271],{"source":34,"section":272},"Nursing Mothers",{"level":274,"text":275,"quote":278,"refs":279},"contraindicated",{"fa":276,"en":277},"برچسب: در کودکان زیر سن مشخص منع مصرف دارد.","Label: contraindicated in children below a stated age.","Diazepam tablets are contraindicated in patients with a known hypersensitivity to diazepam and, because of lack of sufficient clinical experience, in pediatric patients under 6 months of age.",[280],{"source":34,"section":281},"CONTRAINDICATIONS",{"level":256,"text":283,"quote":286,"refs":287},{"fa":284,"en":285},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.",[288],{"source":34,"section":289},"Geriatric Use",{"kind":291,"refs":292,"id":238},"ANDA",[293],{"source":34,"section":294},"SPL approval \u002F marketing category",1792440739305]