[{"data":1,"prerenderedAt":181},["ShallowReactive",2],{"drug-digoxin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":44,"contraindications":64,"warnings":74,"renal":75,"monitoring":76,"interactions":77,"review":78,"examples":81,"atc":82,"iran":84,"links":124,"populations":141,"usApproval":176},"digoxin",1,{"fa":7,"en":8},"دیگوکسین","Digoxin","cardiovascular",{"fa":11,"en":12},"گلیکوزید قلبی","Cardiac glycoside",[14],{"name":15,"market":16},"Lanoxin","US",[18,19,7,20],"lanoxin","لانوکسین","دیژیتال",[22,36],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-125","tablet","oral","125 mcg tablet (scored)",{"amount":28,"unit":29,"perUnit":24,"scored":30},125,"mcg",true,[16],[33],{"source":34,"section":35},"fda-digoxin","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-250","250 mcg tablet (scored)",{"amount":40,"unit":29,"perUnit":24,"scored":30},250,[16],[43],{"source":34,"section":35},[45],{"id":46,"disease":47,"label":48,"population":51,"type":52,"unit":29,"dose":53,"refs":57},"hf","heart-failure",{"fa":49,"en":50},"نارسایی قلبی \u002F کنترل ریت AF","Heart failure \u002F AF rate control",{},"notCalculated",{"reason":54},{"fa":55,"en":56},"دامنه درمانی باریک؛ دوز بر اساس وزن بدون چربی، کارکرد کلیه، سن و داروهای همزمان. بارگیری خوراکی کل: ۵ تا ۱۰ سال ۲۰ تا ۴۵ mcg\u002Fkg؛ بالای ۱۰ سال و بزرگسال ۱۰ تا ۱۵ mcg\u002Fkg — نصف ابتدا، سپس ¼ هر ۶ تا ۸ ساعت دو بار. برای شیرخواران محلول خوراکی.","Narrow therapeutic range; dose by lean body weight, renal function, age and co-medication. Total oral loading: 5–10 y 20–45 mcg\u002Fkg; >10 y and adults 10–15 mcg\u002Fkg — half first, then ¼ every 6–8 h twice. Use oral solution for infants.",[58,60,62],{"source":34,"section":59},"2.2",{"source":34,"section":61},"2.1",{"source":34,"section":63},"2.4",[65],{"id":66,"severity":67,"text":68,"refs":71},"ci","block",{"fa":69,"en":70},"فیبریلاسیون بطنی؛ حساسیت به دیگوکسین.","Ventricular fibrillation; hypersensitivity to digoxin.",[72],{"source":34,"section":73},"4",[],[],[],[],{"status":79,"reviewer":80,"date":80},"unverified",null,[],[83],"C01AA05",{"status":85,"forms":86,"refs":119},"registered",[87,91,95,99,103,107,111,115],{"code":88,"en":89,"fa":90},"00439","DIGOXIN 0.05MG\u002FML 60ML ELIXIR","الگزیر دیگوکسین ۰٫۰۵ میلی‌گرم \u002F میلی‌لیتر ۶۰ میلی‌لیتر",{"code":92,"en":93,"fa":94},"00437","DIGOXIN 0.05MG\u002FML ORAL DROP","قطره خوراکی دیگوکسین ۰٫۰۵ میلی‌گرم \u002F میلی‌لیتر",{"code":96,"en":97,"fa":98},"18338","DIGOXIN 0.125 MG  TAB.","قرص دیگوکسین ۰٫۱۲۵ میلی‌گرم .",{"code":100,"en":101,"fa":102},"00436","DIGOXIN 0.25MG TAB","قرص دیگوکسین ۰٫۲۵ میلی‌گرم",{"code":104,"en":105,"fa":106},"15447","DIGOXIN 0.25MG\u002F1ML AMP","آمپول دیگوکسین ۰٫۲۵ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":108,"en":109,"fa":110},"00438","DIGOXIN 0.5MG\u002F2ML AMP","آمپول دیگوکسین ۰٫۵ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":112,"en":113,"fa":114},"11506","DIGOXIN IMMUNE FAB 40MG VIAL","ویال دیگوکسین ایمنی فاب ۴۰ میلی‌گرم",{"code":116,"en":117,"fa":118},"52047","DIGOXIN INJECTION PARENTERAL 0.25 mg\u002F1mL 1 mL","فرآورده تزریقی دیگوکسین ۰٫۲۵ میلی‌گرم \u002F ۱ میلی‌لیتر ۱ میلی‌لیتر",[120],{"source":121,"section":122,"url":123},"darooyab-generic","G-1638\u002FDigoxin","https:\u002F\u002Fwww.darooyab.ir\u002FG-1638\u002FDigoxin",[125,129,133,136,139],{"kind":126,"url":127,"label":128},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=078556","ANDA078556",{"kind":130,"url":131,"label":132},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=dfac7f13-28be-423d-9389-9089da29da17","FDA Digoxin",{"kind":134,"url":135,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682301.html",{"kind":137,"url":138,"label":83},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C01AA05",{"kind":140,"url":123,"label":8},"darooyab",{"pregnancy":142,"lactation":151,"pediatric":159,"geriatric":168},{"level":143,"text":144,"quote":147,"refs":148},"caution",{"fa":145,"en":146},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Experience with digoxin in pregnant women over several decades, based on published retrospective clinical studies and case reports, has not led to the identification of a drug associated risk of major birth defects, miscarriage or adverse maternal and fetal outcomes.",[149],{"source":34,"section":150},"8.1",{"level":143,"text":152,"quote":155,"refs":156},{"fa":153,"en":154},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary The digoxin dose received through breastfeeding is up to 4% of the neonatal maintenance dosage, which is unlikely to be clinically relevant.",[157],{"source":34,"section":158},"8.2",{"level":160,"text":161,"quote":164,"refs":165},"not-established",{"fa":162,"en":163},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness of digoxin tablets in the control of ventricular rate in children with atrial fibrillation have not been established.",[166],{"source":34,"section":167},"8.4",{"level":143,"text":169,"quote":172,"refs":173},{"fa":170,"en":171},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, which should be based on renal function, and it may be useful to monitor renal function [see Dosage and Administration (2.1) ] .",[174],{"source":34,"section":175},"8.5",{"kind":177,"refs":178,"id":128},"ANDA",[179],{"source":34,"section":180},"SPL approval \u002F marketing category",1792440727149]