[{"data":1,"prerenderedAt":503},["ShallowReactive",2],{"drug-doxycycline":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":49,"contraindications":324,"warnings":345,"renal":346,"monitoring":347,"interactions":348,"review":349,"examples":352,"atc":411,"iran":413,"links":449,"populations":472,"usApproval":498},"doxycycline",1,{"fa":7,"en":8},"داکسی‌سایکلین","Doxycycline","anti-infectives",{"fa":11,"en":12},"تتراسایکلین","Tetracycline",[14],{"name":15,"market":16},"Vibramycin","US",[18,19,20,21,22],"vibramycin","ویبرامایسین","داکسی سایکلین","داکسیسیکلین","doxy",[24,38],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"tab-100","tablet","oral","100 mg tablet",{"amount":30,"unit":31,"perUnit":26,"scored":32},100,"mg",false,[16],[35],{"source":36,"section":37},"fda-doxycycline","How Supplied",{"id":39,"form":40,"route":27,"label":41,"concentration":42,"markets":45,"refs":46},"susp-25","suspension","25 mg \u002F 5 mL oral suspension",{"amount":43,"unit":31,"perVolumeMl":44},25,5,[16],[47],{"source":48,"section":37},"fda-doxysusp",[50,72,93,103,116,128,146,160,180,200,224,246,260,281,303],{"id":51,"disease":52,"label":53,"population":56,"type":60,"unit":31,"dose":61,"refs":62,"notes":65},"adult","susceptible-bacterial-infection",{"fa":54,"en":55},"عفونت‌های حساس — بزرگسال: ۱۰۰ mg هر ۱۲ ساعت روز اول، سپس ۱۰۰ mg\u002Fday","Susceptible infections — adults: 100 mg every 12 h on day 1, then 100 mg\u002Fday",{"minAge":57},{"value":58,"unit":59},18,"year","fixed",{"perDose":30,"dosesPerDay":5},[63],{"source":36,"section":64},"Dosage and Administration",[66],{"text":67,"refs":70},{"fa":68,"en":69},"روز اول ۲۰۰ mg (۱۰۰ هر ۱۲ ساعت)، سپس ۱۰۰ mg\u002Fday. عفونت شدیدتر (به‌ویژه UTI مزمن): ۱۰۰ mg هر ۱۲ ساعت.","Day 1: 200 mg (100 every 12 h), then 100 mg\u002Fday. More severe infections (especially chronic UTI): 100 mg every 12 h.",[71],{"source":36,"section":64},{"id":73,"disease":52,"label":74,"population":77,"type":81,"unit":31,"dose":82,"refs":84,"notes":86},"child",{"fa":75,"en":76},"عفونت کم‌شدت — بالای ۸ سال و کمتر از ۴۵ kg: نگهدارنده ۲٫۲ mg\u002Fkg\u002Fday","Less severe infection — >8 y and \u003C45 kg: maintenance 2.2 mg\u002Fkg\u002Fday",{"minAge":78,"maxWeightKg":80},{"value":79,"unit":59},8,44.99,"weightBased",{"perKgPerDay":83,"dividedDoses":5},2.2,[85],{"source":36,"section":64},[87],{"text":88,"refs":91},{"fa":89,"en":90},"روز اول ۴٫۴ mg\u002Fkg در دو نوبت. ۴۵ kg به بالا: دوز بزرگسال.","Day 1: 4.4 mg\u002Fkg in two doses. 45 kg and above: adult dose.",[92],{"source":36,"section":64},{"id":94,"disease":52,"label":95,"population":98,"type":81,"unit":31,"dose":99,"refs":101},"severe-child",{"fa":96,"en":97},"عفونت شدید\u002Fتهدیدکننده (مثل سیاه‌زخم، تب منقوط) — کمتر از ۴۵ kg: ۲٫۲ mg\u002Fkg هر ۱۲ ساعت","Severe\u002Flife-threatening (e.g. anthrax, RMSF) — \u003C45 kg: 2.2 mg\u002Fkg every 12 h",{"maxWeightKg":80},{"perKgPerDose":83,"intervalHours":100},12,[102],{"source":36,"section":64},{"id":104,"disease":104,"label":105,"population":108,"type":60,"unit":31,"dose":110,"refs":112,"durationDays":114},"chlamydia",{"fa":106,"en":107},"کلامیدیا (اورتریت، سرویسیت، رکتال) — بزرگسال: ۱۰۰ mg دو بار در روز، ۷ روز","Chlamydia (urethral, endocervical, rectal) — adult: 100 mg twice daily, 7 days",{"minAge":109},{"value":58,"unit":59},{"perDose":30,"dosesPerDay":111},2,[113],{"source":48,"section":64},{"min":115,"max":115},7,{"id":117,"disease":117,"label":118,"population":121,"type":60,"unit":31,"dose":123,"refs":124,"durationDays":126},"epididymitis",{"fa":119,"en":120},"اپیدیدیمو-ارکیت کلامیدیایی — ۱۰۰ mg دو بار در روز، حداقل ۱۰ روز","Chlamydial epididymo-orchitis — 100 mg twice daily, at least 10 days",{"minAge":122},{"value":58,"unit":59},{"perDose":30,"dosesPerDay":111},[125],{"source":48,"section":64},{"min":127,"max":127},10,{"id":129,"disease":130,"label":131,"population":134,"type":60,"unit":31,"dose":136,"refs":137,"notes":139},"malaria-adult","malaria",{"fa":132,"en":133},"پیشگیری مالاریا — بزرگسال: ۱۰۰ mg روزانه","Malaria prophylaxis — adult: 100 mg daily",{"minAge":135},{"value":58,"unit":59},{"perDose":30,"dosesPerDay":5},[138],{"source":48,"section":64},[140],{"text":141,"refs":144},{"fa":142,"en":143},"از ۱ تا ۲ روز پیش از سفر تا ۴ هفته پس از ترک منطقه.","From 1–2 days before travel until 4 weeks after leaving.",[145],{"source":48,"section":64},{"id":147,"disease":130,"label":148,"population":151,"type":81,"unit":31,"dose":154,"refs":155,"limits":157},"malaria-child",{"fa":149,"en":150},"پیشگیری مالاریا — کودک بالای ۸ سال: ۲ mg\u002Fkg روزانه (تا دوز بزرگسال)","Malaria prophylaxis — child >8 y: 2 mg\u002Fkg daily (up to adult dose)",{"minAge":152,"maxAge":153},{"value":79,"unit":59},{"value":58,"unit":59},{"perKgPerDay":111,"dividedDoses":5},[156],{"source":48,"section":64},{"maxPerDose":30,"refs":158},[159],{"source":48,"section":64},{"id":161,"disease":52,"label":162,"population":165,"type":81,"unit":31,"dose":168,"refs":169,"notes":171},"child-lt45",{"fa":163,"en":164},"عفونت‌های حساس — کودک بالای ۸ سال زیر ۴۵ kg: روز اول ۴٫۴ mg\u002Fkg در ۲ دوز، سپس ۲٫۲ mg\u002Fkg روزانه","Susceptible infections — child >8 y, \u003C45 kg: 4.4 mg\u002Fkg in 2 doses on day 1, then 2.2 mg\u002Fkg daily",{"minAge":166,"maxAge":167,"maxWeightKg":80},{"value":79,"unit":59},{"value":58,"unit":59},{"perKgPerDay":83,"dividedDoses":5},[170],{"source":48,"section":64},[172],{"text":173,"refs":176},{"fa":174,"en":175},"روز اول ۴٫۴ mg\u002Fkg در دو دوز. ۸ سال و کمتر فقط در عفونت‌های شدید (مثل سیاه‌زخم، تب منقوط): ۲٫۲ mg\u002Fkg هر ۱۲ ساعت.","Day 1: 4.4 mg\u002Fkg in two doses. ≤8 years only for severe infections (e.g. anthrax, Rocky Mountain spotted fever): 2.2 mg\u002Fkg every 12 h.",[177,178],{"source":48,"section":64},{"source":48,"section":179},"Pediatric Use",{"id":181,"disease":182,"label":183,"population":186,"type":60,"unit":31,"dose":188,"refs":189,"notes":192},"brucella-adult","brucellosis",{"fa":184,"en":185},"بروسلوز — بزرگسال: ۱۰۰ mg هر ۱۲ ساعت (همراه استرپتومایسین)","Brucellosis — adult: 100 mg every 12 h (with streptomycin)",{"minWeightKg":187},45,{"perDose":30,"dosesPerDay":111},[190],{"source":36,"section":191},"Dosage and Administration — Adults",[193],{"text":194,"refs":197},{"fa":195,"en":196},"برچسب: بروسلوز «همراه با استرپتومایسین». مدت درمان در برچسب ذکر نشده است.","Label: brucellosis “in conjunction with streptomycin”. The label gives no duration.",[198],{"source":36,"section":199},"Indications and Usage",{"id":201,"disease":182,"label":202,"population":205,"type":81,"unit":31,"dose":207,"refs":208,"allowedFormulations":211,"notes":212},"brucella-child",{"fa":203,"en":204},"بروسلوز — کودک زیر ۴۵ kg (عفونت شدید): ۲٫۲ mg\u002Fkg هر ۱۲ ساعت","Brucellosis — child \u003C45 kg (severe infection): 2.2 mg\u002Fkg every 12 h",{"minAge":206,"maxWeightKg":80},{"value":79,"unit":59},{"perKgPerDose":83,"intervalHours":100},[209],{"source":36,"section":210},"Dosage and Administration — Pediatric Patients",[39],[213,217],{"text":214,"refs":215},{"fa":195,"en":196},[216],{"source":36,"section":199},{"text":218,"refs":221},{"fa":219,"en":220},"زیر ۸ سال (خطر تغییر رنگ دائمی دندان) فقط در عفونت شدید یا تهدیدکننده حیات؛ برای آن از رژیم «عفونت شدید کودک» همین دارو استفاده کنید.","Under 8 y (risk of permanent tooth discolouration) only for severe or life-threatening infection; use this drug’s severe-infection pediatric regimen.",[222],{"source":36,"section":223},"Warnings",{"id":225,"disease":226,"label":227,"population":230,"type":60,"unit":31,"dose":232,"refs":233,"notes":235},"plague-adult","plague",{"fa":228,"en":229},"طاعون — بزرگسال (دوز عمومی برچسب)","Plague — adult (general label dose)",{"minAge":231},{"value":58,"unit":59},{"perDose":30,"dosesPerDay":5},[234],{"source":36,"section":64},[236,240],{"text":237,"refs":238},{"fa":68,"en":69},[239],{"source":36,"section":64},{"text":241,"refs":244},{"fa":242,"en":243},"برچسب داکسی‌سایکلین «طاعون ناشی از یرسینیا پستیس» را در موارد مصرف آورده؛ دوز عمومی برچسب.","The doxycycline label lists “Plague due to Yersinia pestis” among indications; general label dosing.",[245],{"source":36,"section":199},{"id":247,"disease":226,"label":248,"population":251,"type":81,"unit":31,"dose":252,"refs":253,"notes":255},"plague-child",{"fa":249,"en":250},"طاعون — کودک زیر ۴۵ kg (عفونت شدید): ۲٫۲ mg\u002Fkg هر ۱۲ ساعت","Plague — child \u003C45 kg (severe infection): 2.2 mg\u002Fkg every 12 h",{"maxWeightKg":80},{"perKgPerDose":83,"intervalHours":100},[254],{"source":36,"section":64},[256],{"text":257,"refs":258},{"fa":242,"en":243},[259],{"source":36,"section":199},{"id":261,"disease":261,"label":262,"population":265,"type":60,"unit":31,"dose":267,"refs":268,"notes":270},"chancroid",{"fa":263,"en":264},"شانکروئید — بزرگسال (دوز عمومی برچسب)","Chancroid — adult (general label dose)",{"minAge":266},{"value":58,"unit":59},{"perDose":30,"dosesPerDay":5},[269],{"source":36,"section":64},[271,275],{"text":272,"refs":273},{"fa":68,"en":69},[274],{"source":36,"section":64},{"text":276,"refs":279},{"fa":277,"en":278},"برچسب داکسی‌سایکلین «شانکروئید ناشی از هموفیلوس دوکره‌ای» را در موارد مصرف آورده؛ دوز عمومی برچسب.","The doxycycline label lists “Chancroid caused by Haemophilus ducreyi” among indications; general label dosing.",[280],{"source":36,"section":199},{"id":282,"disease":283,"label":284,"population":287,"type":60,"unit":31,"dose":289,"refs":290,"notes":292},"lgv","lymphogranuloma-venereum",{"fa":285,"en":286},"لنفوگرانولوم ونروم — بزرگسال (دوز عمومی برچسب)","LGV — adult (general label dose)",{"minAge":288},{"value":58,"unit":59},{"perDose":30,"dosesPerDay":5},[291],{"source":36,"section":64},[293,297],{"text":294,"refs":295},{"fa":68,"en":69},[296],{"source":36,"section":64},{"text":298,"refs":301},{"fa":299,"en":300},"برچسب داکسی‌سایکلین «لنفوگرانولوم ونروم ناشی از کلامیدیا تراکوماتیس» را در موارد مصرف آورده؛ دوز عمومی برچسب.","The doxycycline label lists “Lymphogranuloma venereum caused by Chlamydia trachomatis” among indications; general label dosing.",[302],{"source":36,"section":199},{"id":304,"disease":304,"label":305,"population":308,"type":60,"unit":31,"dose":310,"refs":311,"notes":313},"donovanosis",{"fa":306,"en":307},"گرانولوم اینگوینال — بزرگسال (دوز عمومی برچسب)","Granuloma inguinale — adult (general label dose)",{"minAge":309},{"value":58,"unit":59},{"perDose":30,"dosesPerDay":5},[312],{"source":36,"section":64},[314,318],{"text":315,"refs":316},{"fa":68,"en":69},[317],{"source":36,"section":64},{"text":319,"refs":322},{"fa":320,"en":321},"برچسب داکسی‌سایکلین «گرانولوم اینگوینال ناشی از کلبسیلا گرانولوماتیس» را در موارد مصرف آورده؛ دوز عمومی برچسب.","The doxycycline label lists “Granuloma inguinale caused by Klebsiella granulomatis” among indications; general label dosing.",[323],{"source":36,"section":199},[325,334],{"id":326,"severity":327,"text":328,"refs":331},"ci","block",{"fa":329,"en":330},"حساسیت به تتراسایکلین‌ها.","Hypersensitivity to any tetracycline.",[332],{"source":36,"section":333},"Contraindications",{"id":335,"severity":336,"rule":337,"text":340,"refs":343},"teeth","warn",{"maxAge":338},{"value":339,"unit":59},9,{"fa":341,"en":342},"۸ سال و کمتر: به‌علت اثر بر دندان و رشد فقط در عفونت شدید یا تهدیدکننده حیات.","8 years or younger: only for severe or life-threatening conditions because of effects on teeth and growth.",[344],{"source":36,"section":179},[],[],[],[],{"status":350,"reviewer":351,"date":351},"unverified",null,[353,358,363,366,370,374,378,381,384,389,393,396,399,402,405,408],{"regimen":51,"formulation":25,"input":354,"expect":357},{"ageYears":355,"weightKg":356},30,70,{"perDose":30},{"regimen":73,"formulation":25,"input":359,"expect":361},{"ageYears":100,"weightKg":360},44,{"perDose":362,"tabletsPerDoseRounded":5},96.8,{"regimen":94,"formulation":25,"input":364,"expect":365},{"ageYears":115,"weightKg":360},{"perDose":362},{"regimen":73,"formulation":25,"input":367,"expect":368},{"ageYears":100,"weightKg":355},{"status":369},"blocked",{"regimen":104,"formulation":25,"input":371,"expect":373},{"ageYears":43,"weightKg":372},60,{"perDose":30,"tabletsPerDoseRounded":5},{"regimen":117,"formulation":25,"input":375,"expect":377},{"ageYears":355,"weightKg":376},75,{"perDose":30},{"regimen":129,"formulation":25,"input":379,"expect":380},{"ageYears":355,"weightKg":356},{"perDose":30},{"regimen":147,"formulation":39,"input":382,"expect":383},{"ageYears":127,"weightKg":355},{"perDose":372,"mlPerDose":100},{"regimen":161,"formulation":39,"input":385,"expect":386},{"ageYears":127,"weightKg":355},{"perDose":387,"mlPerDose":388},66,13.2,{"regimen":181,"formulation":25,"input":390,"expect":392},{"ageYears":391,"weightKg":356},40,{"perDose":30,"tabletsPerDoseRounded":5},{"regimen":201,"formulation":39,"input":394,"expect":395},{"ageYears":127,"weightKg":355},{"perDose":387,"mlPerDose":388},{"regimen":225,"formulation":25,"input":397,"expect":398},{"ageYears":355,"weightKg":356},{"perDose":30},{"regimen":247,"formulation":25,"input":400,"expect":401},{"ageYears":115,"weightKg":360},{"perDose":362},{"regimen":261,"formulation":25,"input":403,"expect":404},{"ageYears":355,"weightKg":356},{"perDose":30},{"regimen":282,"formulation":25,"input":406,"expect":407},{"ageYears":355,"weightKg":356},{"perDose":30},{"regimen":304,"formulation":25,"input":409,"expect":410},{"ageYears":355,"weightKg":356},{"perDose":30},[412],"J01AA02",{"status":414,"forms":415,"refs":444},"registered",[416,420,424,428,432,436,440],{"code":417,"en":418,"fa":419},"11439","DOXYCYCLINE 200MG TAB","قرص داکسی‌سایکلین ۲۰۰ میلی‌گرم",{"code":421,"en":422,"fa":423},"07101","DOXYCYCLINE AMP","آمپول داکسی‌سایکلین",{"code":425,"en":426,"fa":427},"01481","DOXYCYCLINE HYCLATE 100MG TAB","قرص داکسی‌سایکلین هایکلات ۱۰۰ میلی‌گرم",{"code":429,"en":430,"fa":431},"00474","DOXYCYCLINE MONOHYDRATE 100MG CAP","کپسول داکسی‌سایکلین مونوهیدرات ۱۰۰ میلی‌گرم",{"code":433,"en":434,"fa":435},"01482","DOXYCYCLINE MONOHYDRATE 5MG\u002FML 60ML SUSP","سوسپانسیون داکسی‌سایکلین مونوهیدرات ۵ میلی‌گرم \u002F میلی‌لیتر ۶۰ میلی‌لیتر",{"code":437,"en":438,"fa":439},"52747","DOXYCYCLINE (AS HYCLATE) CAPSULE, DELAYED RELEASE ORAL 100 mg","کپسول تأخیری‌رهش داکسی‌سایکلین (معادل هایکلات) ۱۰۰ میلی‌گرم",{"code":441,"en":442,"fa":443},"52474","DOXYCYCLINE (AS HYCLATE) CAPSULE ORAL 100 mg","کپسول داکسی‌سایکلین (معادل هایکلات) ۱۰۰ میلی‌گرم",[445],{"source":446,"section":447,"url":448},"darooyab-generic","G-386\u002FDoxycycline","https:\u002F\u002Fwww.darooyab.ir\u002FG-386\u002FDoxycycline",[450,454,458,461,464,467,470],{"kind":451,"url":452,"label":453},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=210664","ANDA210664",{"kind":455,"url":456,"label":457},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=656ccfe8-dd25-474a-9306-e44e511d7acd","FDA Doxycycline",{"kind":455,"url":459,"label":460},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=e0e80435-1b6a-4361-8c8a-e432f8f23a1b","FDA Doxycycline susp.",{"kind":462,"url":463,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682063.html",{"kind":462,"url":465,"label":466},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601141.html","Doxycycline Injection",{"kind":468,"url":469,"label":412},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01AA02",{"kind":471,"url":448,"label":8},"darooyab",{"pregnancy":473,"lactation":482,"pediatric":491},{"level":474,"text":475,"quote":478,"refs":479},"caution",{"fa":476,"en":477},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","",[480],{"source":36,"section":481},"Pregnancy:",{"level":483,"text":484,"quote":487,"refs":488},"avoid",{"fa":485,"en":486},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Short-term use by lactating women is not necessarily contraindicated; however, the effects of prolonged exposure to doxycycline in breast milk are unknown. 4 Because of the potential for serious adverse reactions in nursing infants from doxycycline, a decision should be made whether to discontinue nursing or to …",[489],{"source":36,"section":490},"Nursing Mothers",{"level":474,"text":492,"quote":495,"refs":496},{"fa":493,"en":494},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Because of the effects of drugs of the tetracycline-class on tooth development and growth, use doxycycline in pediatric patients 8 years of age or less only when the potential benefits are expected to outweigh the risks in severe or life-threatening conditions (e.g., anthrax, Rocky Mountain spotted fever), …",[497],{"source":36,"section":179},{"kind":499,"refs":500,"id":453},"ANDA",[501],{"source":36,"section":502},"SPL approval \u002F marketing category",1792191874104]