[{"data":1,"prerenderedAt":214},["ShallowReactive",2],{"drug-etoposide":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":36,"contraindications":82,"warnings":92,"renal":100,"monitoring":101,"interactions":102,"review":103,"examples":106,"atc":119,"iran":121,"usApproval":153,"links":159,"populations":178},"etoposide",1,{"fa":7,"en":8},"اتوپوزید","Etoposide","antineoplastic-immunomodulating",{"fa":11,"en":12},"مهارکننده توپوایزومراز II","Topoisomerase II inhibitor",[14],{"name":15,"market":16},"Toposar","US",[18,19,20,21,7],"vepesid","toposar","وپسید","اتوپوزاید",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":31,"refs":32},"vial-20","injection","iv","20 mg\u002FmL (100 mg\u002F5 mL, 500 mg, 1 g)",{"amount":29,"unit":30,"perVolumeMl":5},20,"mg",[16],[33],{"source":34,"section":35},"fda-etoposide","How Supplied",[37,68],{"id":38,"disease":39,"label":40,"population":43,"type":47,"unit":30,"dose":48,"refs":50,"durationDays":53,"notes":55},"testis","testicular-cancer",{"fa":41,"en":42},"سرطان بیضه (ترکیبی) — ۵۰ تا ۱۰۰ mg\u002Fm²\u002Fروز روزهای ۱ تا ۵","Testicular cancer (combination) — 50–100 mg\u002Fm²\u002Fday on days 1–5",{"minAge":44},{"value":45,"unit":46},18,"year","bsa",{"perM2PerDay":49,"dividedDoses":5},50,[51],{"source":34,"section":52},"Dosage and Administration",{"min":54,"max":54},5,[56,62],{"text":57,"refs":60},{"fa":58,"en":59},"یا ۱۰۰ mg\u002Fm²\u002Fروز روزهای ۱، ۳ و ۵. دوره‌ها هر ۳ تا ۴ هفته پس از بهبود سمیت. نارسایی کلیه طبق احتیاطات.","Or 100 mg\u002Fm²\u002Fday on days 1, 3 and 5. Repeat courses every 3–4 weeks after recovery. Renal impairment per Precautions.",[61],{"source":34,"section":52},{"text":63,"refs":66},{"fa":64,"en":65},"فقط زیر نظر پزشک متخصص شیمی‌درمانی و در مرکز مجهز. عدد ماشین‌حساب = mg\u002Fm² برچسب × سطح بدن (Mosteller)؛ پروتکل، فاصله دوره‌ها، تنظیم بر اساس CBC و عملکرد کلیه\u002Fکبد با تیم انکولوژی.","Only under an oncologist in an equipped centre. Calculator = label mg\u002Fm² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal\u002Fhepatic function rest with the oncology team.",[67],{"source":34,"section":52},{"id":69,"disease":70,"label":71,"population":74,"type":47,"unit":30,"dose":76,"refs":78,"durationDays":80},"sclc","lung-cancer",{"fa":72,"en":73},"سرطان ریه سلول کوچک (ترکیبی) — ۳۵ mg\u002Fm²\u002Fروز ۴ روز تا ۵۰ mg\u002Fm²\u002Fروز ۵ روز","Small-cell lung cancer (combination) — 35 mg\u002Fm²\u002Fday for 4 days to 50 mg\u002Fm²\u002Fday for 5 days",{"minAge":75},{"value":45,"unit":46},{"perM2PerDay":77,"dividedDoses":5},35,[79],{"source":34,"section":52},{"min":81,"max":54},4,[83],{"id":84,"severity":85,"text":86,"refs":89},"hyper","block",{"fa":87,"en":88},"سابقه حساسیت به اتوپوزید یا اجزای فرآورده.","Previous hypersensitivity to etoposide or any component.",[90],{"source":34,"section":91},"Contraindications",[93],{"text":94,"refs":97},{"fa":95,"en":96},"هشدار جعبه‌ای: سرکوب شدید مغز استخوان با عفونت یا خونریزی.","Boxed warning: severe myelosuppression with infection or bleeding.",[98],{"source":34,"section":99},"Warnings",[],[],[],{"status":104,"reviewer":105,"date":105},"unverified",null,[107,114],{"regimen":38,"formulation":24,"input":108,"expect":112},{"ageYears":109,"weightKg":110,"heightCm":111},55,80,180,{"perDose":113,"mlPerDose":54},100,{"regimen":69,"formulation":24,"input":115,"expect":116},{"ageYears":109,"weightKg":110,"heightCm":111},{"perDose":117,"mlPerDose":118},70,3.5,[120],"L01CB01",{"status":122,"forms":123,"refs":148},"registered",[124,128,132,136,140,144],{"code":125,"en":126,"fa":127},"00517","ETOPOSIDE 100MG CAP","کپسول اتوپوزاید ۱۰۰ میلی‌گرم",{"code":129,"en":130,"fa":131},"00518","ETOPOSIDE 100MG\u002F5ML AMP","آمپول اتوپوزاید ۱۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":133,"en":134,"fa":135},"18934","ETOPOSIDE 200MG\u002F10ML VIAL","ویال اتوپوزاید ۲۰۰ میلی‌گرم \u002F ۱۰ میلی‌لیتر",{"code":137,"en":138,"fa":139},"00519","ETOPOSIDE 25MG CAP","کپسول اتوپوزاید ۲۵ میلی‌گرم",{"code":141,"en":142,"fa":143},"18730","ETOPOSIDE 50MG  VIAL","ویال اتوپوزاید ۵۰ میلی‌گرم",{"code":145,"en":146,"fa":147},"00520","ETOPOSIDE 50MG CAP","کپسول اتوپوزاید ۵۰ میلی‌گرم",[149],{"source":150,"section":151,"url":152},"darooyab-generic","G-996\u002FEtoposide","https:\u002F\u002Fwww.darooyab.ir\u002FG-996\u002FEtoposide",{"kind":154,"refs":155,"id":158},"ANDA",[156],{"source":34,"section":157},"SPL approval \u002F marketing category","ANDA074983",[160,163,167,170,173,176],{"kind":161,"url":162,"label":158},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=074983",{"kind":164,"url":165,"label":166},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=fe870629-104d-4d67-a7c6-f53bc588121e","FDA Etoposide",{"kind":168,"url":169,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa684055.html",{"kind":168,"url":171,"label":172},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa697011.html","Etoposide Injection",{"kind":174,"url":175,"label":120},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L01CB01",{"kind":177,"url":152,"label":8},"darooyab",{"pregnancy":179,"lactation":188,"pediatric":196,"geriatric":205},{"level":180,"text":181,"quote":184,"refs":185},"avoid",{"fa":182,"en":183},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Etoposide can cause fetal harm when administered to a pregnant woman.",[186],{"source":34,"section":187},"Pregnancy",{"level":180,"text":189,"quote":192,"refs":193},{"fa":190,"en":191},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from etoposide, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[194],{"source":34,"section":195},"Nursing Mothers",{"level":197,"text":198,"quote":201,"refs":202},"not-established",{"fa":199,"en":200},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[203],{"source":34,"section":204},"Pediatric Use",{"level":206,"text":207,"quote":210,"refs":211},"caution",{"fa":208,"en":209},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function (see PRECAUTIONS , Renal Impairment for recommended dosing adjustments in patients with renal impairment).",[212],{"source":34,"section":213},"Geriatric Use",1792444709858]