[{"data":1,"prerenderedAt":202},["ShallowReactive",2],{"drug-fentanyl-patch":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":33,"contraindications":61,"warnings":71,"renal":79,"monitoring":80,"interactions":81,"review":82,"examples":85,"atc":86,"iran":88,"links":140,"populations":155,"usApproval":197},"fentanyl-patch",1,{"fa":7,"en":8},"چسب پوستی فنتانیل","Fentanyl transdermal patch","nervous-system",{"fa":11,"en":12},"آگونیست اپیوئیدی طولانی‌اثر","Long-acting opioid agonist",[14],{"name":15,"market":16},"Duragesic","US",[18,19,20],"duragesic","چسب فنتانیل","fentanyl patch",[22],{"id":23,"form":23,"route":24,"label":25,"concentration":26,"markets":28,"refs":29},"patch","transdermal","Patches 12 \u002F 25 \u002F 37.5 \u002F 50 \u002F 62.5 \u002F 75 \u002F 87.5 \u002F 100 mcg\u002Fhour",{"amount":5,"unit":27,"perUnit":27},"application",[16],[30],{"source":31,"section":32},"fda-fentanyl-patch","3",[34],{"id":35,"disease":36,"label":37,"population":40,"type":44,"unit":45,"dose":46,"refs":50},"chronic","severe-pain",{"fa":38,"en":39},"درد شدید مداوم در بیمار مقاوم به اپیوئید — یک چسب هر ۷۲ ساعت","Severe persistent pain in opioid-TOLERANT patients — one patch every 72 h",{"minAge":41},{"value":42,"unit":43},2,"year","notCalculated","mg",{"reason":47},{"fa":48,"en":49},"فقط بیمار مقاوم به اپیوئید (دست‌کم ۶۰ mg مورفین خوراکی در روز یا معادل به مدت ≥۱ هفته). دوز اولیه بر اساس تبدیل از اپیوئید فعلی طبق برچسب؛ کمتر تخمین زدن امن‌تر است. هر ۷۲ ساعت؛ چسب مصرف‌شده تا شده و دفع شود. نارسایی خفیف\u002Fمتوسط کبد یا کلیه: نصف دوز.","Opioid-tolerant patients only (≥60 mg oral morphine\u002Fday or equivalent for ≥1 week). Starting dose by conversion from the current opioid per label; underestimating is safer. Every 72 h; fold used patches and dispose. Mild\u002Fmoderate hepatic or renal impairment: half the dose.",[51,53,55,57,59],{"source":31,"section":52},"2.1",{"source":31,"section":54},"2.3",{"source":31,"section":56},"2.5",{"source":31,"section":58},"2.6",{"source":31,"section":60},"2.8",[62],{"id":63,"severity":64,"text":65,"refs":68},"ci","block",{"fa":66,"en":67},"بیمار غیرمقاوم به اپیوئید؛ درد حاد، متناوب، پس از عمل یا خفیف؛ دپرسیون تنفسی؛ آسم شدید بدون پایش؛ انسداد روده؛ حساسیت.","Not opioid-tolerant; acute, intermittent, postoperative or mild pain; respiratory depression; severe asthma without monitoring; GI obstruction; hypersensitivity.",[69],{"source":31,"section":70},"4",[72],{"text":73,"refs":76},{"fa":74,"en":75},"هشدار جعبه‌ای: دپرسیون تنفسی کشنده (به‌ویژه بیمار غیرمقاوم)، مواجهه تصادفی کودک کشنده است، گرما (تب، پد گرم، سونا) جذب را بالا می‌برد، تداخل با بنزودیازپین و مهارکننده CYP3A4.","Boxed warning: fatal respiratory depression (especially if not opioid-tolerant), accidental exposure in children is fatal, heat (fever, heating pads, saunas) raises absorption, interactions with benzodiazepines and CYP3A4 inhibitors.",[77],{"source":31,"section":78},"Boxed Warning",[],[],[],{"status":83,"reviewer":84,"date":84},"unverified",null,[],[87],"N02AB03",{"status":89,"forms":90,"refs":135},"registered",[91,95,99,103,107,111,115,119,123,127,131],{"code":92,"en":93,"fa":94},"02545","FENTANYLE 100MCG\u002FH PATCH","پچ پوستی فنتانیل ۱۰۰ میکروگرم \u002F H",{"code":96,"en":97,"fa":98},"01987","FENTANYLE 25MCG\u002FH PATCH","پچ پوستی فنتانیل ۲۵ میکروگرم \u002F H",{"code":100,"en":101,"fa":102},"01988","FENTANYLE 50MCG\u002FH PATCH","پچ پوستی فنتانیل ۵۰ میکروگرم \u002F H",{"code":104,"en":105,"fa":106},"02546","FENTANYLE 75MCG\u002FH PATCH","پچ پوستی فنتانیل ۷۵ میکروگرم \u002F H",{"code":108,"en":109,"fa":110},"01359","FENTANYLE CITRATE 50MCG\u002FML 10ML AMP","آمپول فنتانیل سیترات ۵۰ میکروگرم \u002F میلی‌لیتر ۱۰ میلی‌لیتر",{"code":112,"en":113,"fa":114},"07830","FENTANYLE CITRATE 50MCG\u002FML 2ML AMP","آمپول فنتانیل سیترات ۵۰ میکروگرم \u002F میلی‌لیتر ۲ میلی‌لیتر",{"code":116,"en":117,"fa":118},"10376","FENTANYLE CITRATE 50MCG\u002FML 5ML AMP","آمپول فنتانیل سیترات ۵۰ میکروگرم \u002F میلی‌لیتر ۵ میلی‌لیتر",{"code":120,"en":121,"fa":122},"52261","FENTANYL (AS CITRATE) INJECTION PARENTERAL 50 ug\u002F1mL 5 mL","فرآورده تزریقی فنتانیل (معادل سیترات) ۵۰ میکروگرم \u002F ۱ میلی‌لیتر ۵ میلی‌لیتر",{"code":124,"en":125,"fa":126},"51007","FENTANYL CITRATE TABLET SUBLINGUAL 100 ug","قرص زیرزبانی فنتانیل سیترات ۱۰۰ میکروگرم",{"code":128,"en":129,"fa":130},"51013","FENTANYL CITRATE TABLET SUBLINGUAL 200 ug","قرص زیرزبانی فنتانیل سیترات ۲۰۰ میکروگرم",{"code":132,"en":133,"fa":134},"51014","FENTANYL CITRATE TABLET SUBLINGUAL 300 ug","قرص زیرزبانی فنتانیل سیترات ۳۰۰ میکروگرم",[136],{"source":137,"section":138,"url":139},"darooyab-generic","G-82\u002FFentanyl","https:\u002F\u002Fwww.darooyab.ir\u002FG-82\u002FFentanyl",[141,145,149,152],{"kind":142,"url":143,"label":144},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=077154","ANDA077154",{"kind":146,"url":147,"label":148},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=e15a7e9b-8025-49dd-9a6d-bafcccf1959f","FDA Fentanyl patch",{"kind":150,"url":151,"label":87},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N02AB03",{"kind":153,"url":139,"label":154},"darooyab","Fentanyl",{"pregnancy":156,"lactation":164,"pediatric":172,"geriatric":181,"reproductive":189},{"level":157,"text":158,"quote":161,"refs":162},"avoid",{"fa":159,"en":160},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Neonatal Opioid Withdrawal Syndrome (NOWS) Advise pregnant women using opioids for an extended period of time of the risk of Neonatal Opioid Withdrawal Syndrome, which may be life-threatening if not recognized and treated.",[163],{"source":31,"section":78},{"level":157,"text":165,"quote":168,"refs":169},{"fa":166,"en":167},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions, including excess sedation and respiratory depression in a breastfed infant, advise patients that breastfeeding is not recommended during treatment with fentanyl transdermal system.",[170],{"source":31,"section":171},"8.2",{"level":173,"text":174,"quote":177,"refs":178},"caution",{"fa":175,"en":176},"برچسب: در کودکان ۲ سال به بالا فقط اگر مقاوم به اپیوئید باشند. مواجهه تصادفی حتی یک چسب در کودک کشنده است.","Label: children ≥2 y only if opioid-tolerant. Accidental exposure to even one patch is fatal in children.","The safety of fentanyl transdermal system was evaluated in three open-label trials in 289 pediatric patients with chronic pain, 2 years of age through 18 years of age.",[179],{"source":31,"section":180},"8.4",{"level":173,"text":182,"quote":185,"refs":186},{"fa":183,"en":184},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[187],{"source":31,"section":188},"8.5",{"level":173,"text":190,"quote":193,"refs":194},{"fa":191,"en":192},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Use of opioids for an extended period of time may cause reduced fertility in females and males of reproductive potential.",[195],{"source":31,"section":196},"8.3",{"kind":198,"refs":199,"id":144},"ANDA",[200],{"source":31,"section":201},"SPL approval \u002F marketing category",1792191878163]