[{"data":1,"prerenderedAt":285},["ShallowReactive",2],{"drug-gabapentin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":80,"contraindications":152,"warnings":172,"renal":173,"monitoring":174,"interactions":175,"review":176,"examples":179,"atc":196,"iran":198,"links":226,"populations":246,"usApproval":280},"gabapentin",1,{"fa":7,"en":8},"گاباپنتین","Gabapentin","nervous-system",{"fa":11,"en":12},"ضدتشنج \u002F ضددرد نوروپاتیک","Anticonvulsant \u002F neuropathic pain",[14],{"name":15,"market":16},"Neurontin","US",[18,19,7,20],"neurontin","نورونتین","گاباپنتین ۳۰۰",[22,36,44,52,62,70],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"cap-100","capsule","oral","100 mg capsule",{"amount":28,"unit":29,"perUnit":24,"scored":30},100,"mg",false,[16],[33],{"source":34,"section":35},"fda-neurontin","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"cap-300","300 mg capsule",{"amount":40,"unit":29,"perUnit":24,"scored":30},300,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"cap-400","400 mg capsule",{"amount":48,"unit":29,"perUnit":24,"scored":30},400,[16],[51],{"source":34,"section":35},{"id":53,"form":54,"route":25,"label":55,"concentration":56,"markets":59,"refs":60},"tab-600","tablet","600 mg tablet (scored)",{"amount":57,"unit":29,"perUnit":54,"scored":58},600,true,[16],[61],{"source":34,"section":35},{"id":63,"form":54,"route":25,"label":64,"concentration":65,"markets":67,"refs":68},"tab-800","800 mg tablet (scored)",{"amount":66,"unit":29,"perUnit":54,"scored":58},800,[16],[69],{"source":34,"section":35},{"id":71,"form":72,"route":25,"label":73,"concentration":74,"markets":77,"refs":78},"sol-250","solution","250 mg\u002F5 mL oral solution",{"amount":75,"unit":29,"perVolumeMl":76},250,5,[16],[79],{"source":34,"section":35},[81,108,131],{"id":82,"disease":83,"label":84,"population":87,"type":91,"unit":29,"dose":92,"refs":97,"notes":101},"phn","neuropathic-pain",{"fa":85,"en":86},"درد پس از زونا — بزرگسال: روز ۱: ۳۰۰، روز ۲: ۶۰۰، روز ۳: ۹۰۰ mg\u002Fday","Postherpetic neuralgia — adults: day 1 300, day 2 600, day 3 900 mg\u002Fday",{"minAge":88},{"value":89,"unit":90},18,"year","titration",{"dividedDoses":93,"titration":94},3,{"start":95,"increment":40,"incrementEveryDays":5,"targetMin":96,"targetMax":96,"max":96},900,1800,[98],{"source":99,"section":100},"fda-gabapentin","2.1",[102],{"text":103,"refs":106},{"fa":104,"en":105},"روز ۱: ۳۰۰ mg تک‌دوز؛ روز ۲: ۳۰۰ دو بار؛ روز ۳: ۳۰۰ سه بار؛ سپس تا ۱۸۰۰ mg\u002Fday (۶۰۰ سه بار). بالای ۱۸۰۰ سود اضافه نشان نداده. دوز نمایش‌داده‌شده از روز ۳ است.","Day 1: 300 mg once; day 2: 300 twice; day 3: 300 three times; then up to 1,800 mg\u002Fday (600 tid). No added benefit shown above 1,800. Displayed dose is from day 3.",[107],{"source":99,"section":100},{"id":109,"disease":110,"label":111,"population":114,"type":117,"unit":29,"dose":118,"refs":119,"notes":122},"epi-12","epilepsy",{"fa":112,"en":113},"صرع پارشیل — ۱۲ سال به بالا: ۳۰۰ mg سه بار در روز","Partial seizures — ≥12 y: 300 mg three times daily",{"minAge":115},{"value":116,"unit":90},12,"fixed",{"perDose":40,"perDoseMax":57,"dosesPerDay":93},[120],{"source":99,"section":121},"2.2",[123],{"text":124,"refs":127},{"fa":125,"en":126},"نگهدارنده ۳۰۰ تا ۶۰۰ mg سه بار؛ تا ۲۴۰۰ mg\u002Fday در مطالعات طولانی. فاصله دوزها بیش از ۱۲ ساعت نشود. نارسایی کلیه: کاهش دوز (جدول ۱).","Maintenance 300–600 mg tid; up to 2,400 mg\u002Fday in long-term studies. Interval between doses ≤12 h. Renal impairment: reduce (Table 1).",[128,129],{"source":99,"section":121},{"source":99,"section":130},"2.3",{"id":132,"disease":110,"label":133,"population":136,"type":139,"unit":29,"dose":140,"refs":143,"notes":145},"epi-3-11",{"fa":134,"en":135},"صرع پارشیل — ۳ تا ۱۱ سال: شروع ۱۰ تا ۱۵ mg\u002Fkg\u002Fday در ۳ نوبت","Partial seizures — 3–11 y: start 10–15 mg\u002Fkg\u002Fday in 3 doses",{"minAge":137,"maxAge":138},{"value":93,"unit":90},{"value":116,"unit":90},"weightBased",{"perKgPerDay":141,"perKgPerDayMax":142,"dividedDoses":93},10,15,[144],{"source":99,"section":121},[146],{"text":147,"refs":150},{"fa":148,"en":149},"طی حدود ۳ روز به نگهدارنده: ۳ تا ۴ سال ۴۰ mg\u002Fkg\u002Fday؛ ۵ تا ۱۱ سال ۲۵ تا ۳۵ mg\u002Fkg\u002Fday (سه نوبت). تا ۵۰ mg\u002Fkg\u002Fday مصرف شده.","Titrate over about 3 days to maintenance: 3–4 y 40 mg\u002Fkg\u002Fday; 5–11 y 25–35 mg\u002Fkg\u002Fday (three doses). Up to 50 mg\u002Fkg\u002Fday has been used.",[151],{"source":99,"section":121},[153,162],{"id":154,"severity":155,"text":156,"refs":159},"ci","block",{"fa":157,"en":158},"حساسیت به گاباپنتین.","Hypersensitivity to gabapentin.",[160],{"source":99,"section":161},"4",{"id":163,"severity":155,"rule":164,"text":166,"refs":169},"under-3",{"maxAge":165},{"value":93,"unit":90},{"fa":167,"en":168},"زیر ۳ سال ثابت نشده.","Not established below 3 years.",[170],{"source":99,"section":171},"8.4",[],[],[],[],{"status":177,"reviewer":178,"date":178},"unverified",null,[180,185,190],{"regimen":82,"formulation":37,"input":181,"expect":184},{"ageYears":182,"weightKg":183},65,70,{"perDose":40,"tabletsPerDoseRounded":5},{"regimen":109,"formulation":37,"input":186,"expect":189},{"ageYears":187,"weightKg":188},14,50,{"perDose":40,"upperPerDose":57},{"regimen":132,"formulation":71,"input":191,"expect":194},{"ageYears":192,"weightKg":193},6,20,{"perDose":195,"upperPerDose":28},66.67,[197],"N02BF01",{"status":199,"forms":200,"refs":221},"registered",[201,205,209,213,217],{"code":202,"en":203,"fa":204},"00572","GABAPENTIN 100MG CAP","کپسول گاباپنتین ۱۰۰ میلی‌گرم",{"code":206,"en":207,"fa":208},"00573","GABAPENTIN 300MG CAP","کپسول گاباپنتین ۳۰۰ میلی‌گرم",{"code":210,"en":211,"fa":212},"00574","GABAPENTIN 400MG CAP","کپسول گاباپنتین ۴۰۰ میلی‌گرم",{"code":214,"en":215,"fa":216},"08460","GABAPENTIN 600MG TAB","قرص گاباپنتین ۶۰۰ میلی‌گرم",{"code":218,"en":219,"fa":220},"08848","GABAPENTIN 800MG TAB","قرص گاباپنتین ۸۰۰ میلی‌گرم",[222],{"source":223,"section":224,"url":225},"darooyab-generic","G-667\u002FGabapentin","https:\u002F\u002Fwww.darooyab.ir\u002FG-667\u002FGabapentin",[227,231,235,238,241,244],{"kind":228,"url":229,"label":230},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=206943","ANDA206943",{"kind":232,"url":233,"label":234},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=3dac0d5f-6e65-4c58-9d2a-4f6910b2d4ef","FDA Gabapentin",{"kind":232,"url":236,"label":237},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=97935fd9-1d4a-43b6-a5d9-de994591187b","FDA Neurontin",{"kind":239,"url":240,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa694007.html",{"kind":242,"url":243,"label":197},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N02BF01",{"kind":245,"url":225,"label":8},"darooyab",{"pregnancy":247,"lactation":256,"pediatric":264,"geriatric":272},{"level":248,"text":249,"quote":252,"refs":253},"caution",{"fa":250,"en":251},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary The totality of available data from published prospective and retrospective cohort studies pertaining to gabapentin use during pregnancy has not indicated an increased risk of major birth defects or miscarriage.",[254],{"source":99,"section":255},"8.1",{"level":248,"text":257,"quote":260,"refs":261},{"fa":258,"en":259},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Gabapentin is secreted in human milk following oral administration.",[262],{"source":99,"section":263},"8.2",{"level":265,"text":266,"quote":269,"refs":270},"not-established",{"fa":267,"en":268},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness of gabapentin in the management of postherpetic neuralgia in pediatric patients have not been established.",[271],{"source":99,"section":171},{"level":248,"text":273,"quote":276,"refs":277},{"fa":274,"en":275},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[278],{"source":99,"section":279},"8.5",{"kind":281,"refs":282,"id":230},"ANDA",[283],{"source":99,"section":284},"SPL approval \u002F marketing category",1792191878191]