[{"data":1,"prerenderedAt":202},["ShallowReactive",2],{"drug-glyburide":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":54,"contraindications":100,"warnings":110,"renal":117,"monitoring":118,"interactions":119,"review":120,"examples":123,"atc":129,"iran":131,"links":143,"populations":162,"usApproval":197},"glyburide",1,{"fa":7,"en":8},"گلی‌بن‌کلامید","Glibenclamide (glyburide)","alimentary-metabolism",{"fa":11,"en":12},"سولفونیل‌اوره","Sulfonylurea",[14],{"name":15,"market":16},"Diabeta","US",[18,4,19,20,21,22],"glibenclamide","گلیبنکلامید","گلی بن کلامید","daonil","sulfonylurea",[24,38,46],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"tab-1-25","tablet","oral","1.25 mg tablet (scored)",{"amount":30,"unit":31,"perUnit":26,"scored":32},1.25,"mg",true,[16],[35],{"source":36,"section":37},"fda-glyburide","How Supplied",{"id":39,"form":26,"route":27,"label":40,"concentration":41,"markets":43,"refs":44},"tab-2-5","2.5 mg tablet (scored)",{"amount":42,"unit":31,"perUnit":26,"scored":32},2.5,[16],[45],{"source":36,"section":37},{"id":47,"form":26,"route":27,"label":48,"concentration":49,"markets":51,"refs":52},"tab-5","5 mg tablet (scored)",{"amount":50,"unit":31,"perUnit":26,"scored":32},5,[16],[53],{"source":36,"section":37},[55,85],{"id":56,"disease":57,"label":58,"population":61,"type":65,"unit":31,"dose":66,"refs":67,"limits":70,"notes":75},"adult","type-2-diabetes",{"fa":59,"en":60},"دیابت نوع ۲ — شروع ۲٫۵ تا ۵ mg با صبحانه","Type 2 diabetes — start 2.5–5 mg with breakfast",{"minAge":62},{"value":63,"unit":64},18,"year","fixed",{"perDose":42,"perDoseMax":50,"dosesPerDay":5},[68],{"source":36,"section":69},"Dosage and Administration",{"maxPerDay":71,"refs":72},20,[73],{"source":36,"section":74},"Dosage and Administration, Maintenance Dose",[76],{"text":77,"refs":80},{"fa":78,"en":79},"بیماران حساس: ۱٫۲۵ mg. افزایش حداکثر ۲٫۵ mg در هفته؛ نگهدارنده ۱٫۲۵ تا ۲۰ mg\u002Fday. بالای ۱۰ mg\u002Fday ممکن است دو بار در روز بهتر باشد.","Sensitive patients: 1.25 mg. Increase by no more than 2.5 mg weekly; maintenance 1.25–20 mg\u002Fday. Above 10 mg\u002Fday twice-daily dosing may work better.",[81,82,83],{"source":36,"section":69},{"source":36,"section":74},{"source":36,"section":84},"Dosage and Administration, Dosage Interval",{"id":86,"disease":57,"label":87,"population":90,"type":92,"unit":31,"dose":93,"refs":97},"peds",{"fa":88,"en":89},"زیر ۱۸ سال","Under 18 years",{"maxAge":91},{"value":63,"unit":64},"notCalculated",{"reason":94},{"fa":95,"en":96},"بی‌خطری و اثربخشی در کودکان ثابت نشده است.","Safety and effectiveness in children not established.",[98],{"source":36,"section":99},"Pediatric Use",[101],{"id":102,"severity":103,"text":104,"refs":107},"ci","block",{"fa":105,"en":106},"حساسیت یا آلرژی به دارو (و سایر موارد بخش منع مصرف).","Known hypersensitivity or allergy to the drug (and other items in Contraindications).",[108],{"source":36,"section":109},"Contraindications",[111],{"text":112,"refs":115},{"fa":113,"en":114},"خطر هیپوگلیسمی؛ وعده غذایی منظم لازم است.","Risk of hypoglycaemia; regular meals needed.",[116],{"source":36,"section":69},[],[],[],{"status":121,"reviewer":122,"date":122},"unverified",null,[124],{"regimen":56,"formulation":39,"input":125,"expect":128},{"ageYears":126,"weightKg":127},55,80,{"perDose":42,"upperPerDose":50},[130],"A10BB01",{"status":132,"forms":133,"refs":138},"registered",[134],{"code":135,"en":136,"fa":137},"00595","GLIBENCLAMIDE 5MG TAB","قرص گلی‌بن‌کلامید ۵ میلی‌گرم",[139],{"source":140,"section":141,"url":142},"darooyab-generic","G-625\u002FGlibenclamide","https:\u002F\u002Fwww.darooyab.ir\u002FG-625\u002FGlibenclamide",[144,148,152,156,159],{"kind":145,"url":146,"label":147},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=074388","ANDA074388",{"kind":149,"url":150,"label":151},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=a56f100f-0f42-4188-81ab-04644b824040","FDA Glyburide",{"kind":153,"url":154,"label":155},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa684058.html","Glyburide",{"kind":157,"url":158,"label":130},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A10BB01",{"kind":160,"url":142,"label":161},"darooyab","Glibenclamide",{"pregnancy":163,"lactation":172,"pediatric":181,"geriatric":189},{"level":164,"text":165,"quote":168,"refs":169},"caution",{"fa":166,"en":167},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Pregnancy Category B Reproduction studies have been performed in rats and rabbits at doses up to 500 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to glyburide.",[170],{"source":36,"section":171},"Pregnancy",{"level":173,"text":174,"quote":177,"refs":178},"avoid",{"fa":175,"en":176},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because the potential for hypoglycemia in nursing infants may exist, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[179],{"source":36,"section":180},"Nursing Mothers",{"level":182,"text":183,"quote":186,"refs":187},"not-established",{"fa":184,"en":185},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[188],{"source":36,"section":99},{"level":164,"text":190,"quote":193,"refs":194},{"fa":191,"en":192},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Hypoglycemia may be difficult to recognize in the elderly (see PRECAUTIONS ).",[195],{"source":36,"section":196},"Geriatric Use",{"kind":198,"refs":199,"id":147},"ANDA",[200],{"source":36,"section":201},"SPL approval \u002F marketing category",1792191867430]