[{"data":1,"prerenderedAt":291},["ShallowReactive",2],{"drug-hydralazine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":70,"contraindications":162,"warnings":179,"renal":180,"monitoring":181,"interactions":182,"review":183,"examples":186,"atc":210,"iran":212,"links":240,"populations":260,"usApproval":286},"hydralazine",1,{"fa":7,"en":8},"هیدرالازین","Hydralazine","cardiovascular",{"fa":11,"en":12},"گشادکننده عروق","Vasodilator",[14],{"name":15,"market":16},"Apresoline","US",[18,19,7],"apresoline","آپرسولین",[21,35,43,51,59],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-10","tablet","oral","10 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},10,"mg",false,[16],[32],{"source":33,"section":34},"fda-hydralazine","How Supplied",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-25","25 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},25,[16],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":48,"refs":49},"tab-50","50 mg tablet",{"amount":47,"unit":28,"perUnit":23,"scored":29},50,[16],[50],{"source":33,"section":34},{"id":52,"form":23,"route":24,"label":53,"concentration":54,"markets":56,"refs":57},"tab-100","100 mg tablet",{"amount":55,"unit":28,"perUnit":23,"scored":29},100,[16],[58],{"source":33,"section":34},{"id":60,"form":61,"route":62,"label":63,"concentration":64,"markets":66,"refs":67},"inj-20","injection","iv","20 mg\u002FmL injection (1 mL vial)",{"amount":65,"unit":28,"perVolumeMl":5},20,[16],[68],{"source":69,"section":34},"fda-hydralazine-inj",[71,99,124,143],{"id":72,"disease":73,"label":74,"population":77,"type":81,"unit":28,"dose":82,"refs":88,"notes":91,"allowedFormulations":98},"adult","hypertension",{"fa":75,"en":76},"فشار خون — بزرگسال: ۱۰ mg چهار بار در روز (شروع)","Hypertension — adults: 10 mg four times daily (start)",{"minAge":78},{"value":79,"unit":80},18,"year","titration",{"dividedDoses":83,"titration":84},4,{"start":85,"targetMin":86,"targetMax":86,"max":87},40,200,300,[89],{"source":33,"section":90},"Dosage and Administration",[92],{"text":93,"refs":96},{"fa":94,"en":95},"روز ۲ تا ۴: ۱۰ mg چهار بار؛ بقیه هفته اول ۲۵ mg چهار بار؛ از هفته دوم ۵۰ mg چهار بار. گاهی تا ۳۰۰ mg\u002Fday.","Days 2–4: 10 mg qid; rest of week 1: 25 mg qid; from week 2: 50 mg qid. Occasionally up to 300 mg\u002Fday.",[97],{"source":33,"section":90},[22,36,44,52],{"id":100,"disease":73,"label":101,"population":104,"type":106,"unit":28,"dose":107,"refs":109,"limits":112,"notes":116,"allowedFormulations":123},"peds",{"fa":102,"en":103},"فشار خون — کودکان: ۰٫۷۵ mg\u002Fkg\u002Fday در ۴ نوبت","Hypertension — children: 0.75 mg\u002Fkg\u002Fday in 4 doses",{"maxAge":105},{"value":79,"unit":80},"weightBased",{"perKgPerDay":108,"dividedDoses":83},0.75,[110],{"source":33,"section":111},"Pediatric Use",{"maxPerKgPerDay":113,"maxPerDay":86,"refs":114},7.5,[115],{"source":33,"section":111},[117],{"text":118,"refs":121},{"fa":119,"en":120},"افزایش تدریجی طی ۳ تا ۴ هفته تا حداکثر ۷٫۵ mg\u002Fkg یا ۲۰۰ mg در روز.","Increase gradually over 3–4 weeks to max 7.5 mg\u002Fkg or 200 mg daily.",[122],{"source":33,"section":111},[22,36,44,52],{"id":62,"disease":125,"label":126,"population":129,"type":131,"unit":28,"dose":132,"refs":133,"allowedFormulations":135,"notes":136},"hypertensive-emergency",{"fa":127,"en":128},"فشار خون شدید (وقتی خوراکی ممکن نیست) — ۲۰ تا ۴۰ mg وریدی یا عضلانی، تکرار در صورت نیاز","Severe hypertension (when oral not possible) — 20–40 mg IV or IM, repeat as needed",{"minAge":130},{"value":79,"unit":80},"fixed",{"perDose":65,"perDoseMax":85,"dosesPerDay":5},[134],{"source":69,"section":90},[60],[137],{"text":138,"refs":141},{"fa":139,"en":140},"فشار مکرر کنترل شود؛ اثر حداکثر ۱۰ تا ۸۰ دقیقه. در آسیب کلیوی دوز کمتر. معمولاً ظرف ۲۴ تا ۴۸ ساعت به خوراکی.","Check BP frequently; maximal fall at 10–80 min. Lower dose with marked renal damage. Usually switch to oral within 24–48 h.",[142],{"source":69,"section":90},{"id":144,"disease":145,"label":146,"population":149,"type":131,"unit":28,"dose":151,"refs":152,"allowedFormulations":154,"notes":155},"iv-preg","hypertension-pregnancy",{"fa":147,"en":148},"فشار خون شدید بارداری (بیمارستانی) — ۲۰ تا ۴۰ mg وریدی یا عضلانی","Severe hypertension in pregnancy (hospital) — 20–40 mg IV or IM",{"minAge":150},{"value":79,"unit":80},{"perDose":65,"perDoseMax":85,"dosesPerDay":5},[153],{"source":69,"section":90},[60],[156],{"text":157,"refs":160},{"fa":158,"en":159},"دوز برچسب عمومی است؛ برچسب دوز جداگانه بارداری ندارد.","General label dose; the label has no separate pregnancy dose.",[161],{"source":69,"section":90},[163,172],{"id":164,"severity":165,"text":166,"refs":169},"ci","block",{"fa":167,"en":168},"حساسیت؛ بیماری عروق کرونر؛ بیماری روماتیسمی دریچه میترال.","Hypersensitivity; coronary artery disease; mitral valvular rheumatic heart disease.",[170],{"source":33,"section":171},"Contraindications",{"id":173,"severity":165,"text":174,"refs":177},"inj-ci",{"fa":175,"en":176},"تزریقی: حساسیت؛ بیماری عروق کرونر؛ بیماری روماتیسمی دریچه میترال.","Injection: hypersensitivity; coronary artery disease; rheumatic mitral valve disease.",[178],{"source":69,"section":171},[],[],[],[],{"status":184,"reviewer":185,"date":185},"unverified",null,[187,191,197,202,205],{"regimen":72,"formulation":22,"input":188,"expect":190},{"ageYears":47,"weightKg":189},80,{"perDose":27},{"regimen":100,"formulation":22,"input":192,"expect":195},{"ageYears":193,"weightKg":194},8,30,{"status":196},"blocked",{"regimen":100,"formulation":22,"input":198,"expect":201},{"ageYears":199,"weightKg":200},14,53.33,{"perDose":27},{"regimen":62,"formulation":60,"input":203,"expect":204},{"ageYears":47,"weightKg":189},{"perDose":65,"upperPerDose":85},{"regimen":144,"formulation":60,"input":206,"expect":209},{"ageYears":207,"weightKg":208},28,70,{"perDose":65,"upperPerDose":85},[211],"C02DB02",{"status":213,"forms":214,"refs":235},"registered",[215,219,223,227,231],{"code":216,"en":217,"fa":218},"00631","HYDRALAZINE HCL 10MG TAB","قرص هیدرالازین هیدروکلراید ۱۰ میلی‌گرم",{"code":220,"en":221,"fa":222},"00632","HYDRALAZINE HCL 20MG\u002FML AMP","آمپول هیدرالازین هیدروکلراید ۲۰ میلی‌گرم \u002F میلی‌لیتر",{"code":224,"en":225,"fa":226},"11435","HYDRALAZINE HCL 25MG AMP","آمپول هیدرالازین هیدروکلراید ۲۵ میلی‌گرم",{"code":228,"en":229,"fa":230},"00633","HYDRALAZINE HCL 25MG TAB","قرص هیدرالازین هیدروکلراید ۲۵ میلی‌گرم",{"code":232,"en":233,"fa":234},"00634","HYDRALAZINE HCL 50MG TAB","قرص هیدرالازین هیدروکلراید ۵۰ میلی‌گرم",[236],{"source":237,"section":238,"url":239},"darooyab-generic","G-1705\u002FHydralazine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1705\u002FHydralazine",[241,245,249,252,255,258],{"kind":242,"url":243,"label":244},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=200770","ANDA200770",{"kind":246,"url":247,"label":248},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=b3d1786d-c3ff-42f1-a09f-37a9c9021e5a","FDA Hydralazine",{"kind":246,"url":250,"label":251},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f0db9c3c-d841-46f9-8409-9ffca83d7a97","FDA Hydralazine inj.",{"kind":253,"url":254,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682246.html",{"kind":256,"url":257,"label":211},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C02DB02",{"kind":259,"url":239,"label":8},"darooyab",{"pregnancy":261,"lactation":270,"pediatric":278},{"level":262,"text":263,"quote":266,"refs":267},"caution",{"fa":264,"en":265},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Pregnancy Category C Animal studies indicate that hydrALAZINE is teratogenic in mice at 20 to 30 times the maximum daily human dose of 200 to 300 mg and possibly in rabbits at 10 to 15 times the maximum daily human dose, but that it is nonteratogenic in rats.",[268],{"source":33,"section":269},"Pregnancy",{"level":262,"text":271,"quote":274,"refs":275},{"fa":272,"en":273},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","HydrALAZINE has been shown to be excreted in breast milk.",[276],{"source":33,"section":277},"Nursing Mothers",{"level":279,"text":280,"quote":283,"refs":284},"not-established",{"fa":281,"en":282},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established in controlled clinical trials, although there is experience with the use of hydrALAZINE in pediatric patients.",[285],{"source":33,"section":111},{"kind":287,"refs":288,"id":244},"ANDA",[289],{"source":33,"section":290},"SPL approval \u002F marketing category",1792191869666]