[{"data":1,"prerenderedAt":360},["ShallowReactive",2],{"drug-levetiracetam":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":91,"contraindications":200,"warnings":210,"renal":211,"monitoring":212,"interactions":213,"review":214,"examples":217,"atc":241,"iran":243,"links":295,"populations":321,"usApproval":355},"levetiracetam",1,{"fa":7,"en":8},"لووتیراستام","Levetiracetam","nervous-system",{"fa":11,"en":12},"ضدتشنج","Anticonvulsant",[14],{"name":15,"market":16},"Keppra","US",[18,19,20,7],"keppra","کپرا","لوتیراستام",[22,36,45,53,64,75,83],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-500","tablet","oral","500 mg tablet (scored)",{"amount":28,"unit":29,"perUnit":24,"scored":30},500,"mg",true,[16],[33],{"source":34,"section":35},"fda-levetiracetam","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":42,"refs":43},"tab-750","750 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":41},750,false,[16],[44],{"source":34,"section":35},{"id":46,"form":24,"route":25,"label":47,"concentration":48,"markets":50,"refs":51},"tab-1000","1000 mg tablet",{"amount":49,"unit":29,"perUnit":24,"scored":41},1000,[16],[52],{"source":34,"section":35},{"id":54,"form":55,"route":25,"label":56,"concentration":57,"markets":59,"refs":60},"sol-100","solution","100 mg\u002FmL oral solution",{"amount":58,"unit":29,"perVolumeMl":5},100,[16],[61],{"source":62,"section":63},"fda-levetiracetam-sol","Description",{"id":65,"form":66,"route":67,"label":68,"concentration":69,"markets":71,"refs":72},"bag-5","injection","iv","500 mg\u002F100 mL ready-to-use IV bag (5 mg\u002FmL)",{"amount":70,"unit":29,"perVolumeMl":5},5,[16],[73],{"source":74,"section":35},"fda-levetiracetam-inj",{"id":76,"form":66,"route":67,"label":77,"concentration":78,"markets":80,"refs":81},"bag-10","1000 mg\u002F100 mL ready-to-use IV bag (10 mg\u002FmL)",{"amount":79,"unit":29,"perVolumeMl":5},10,[16],[82],{"source":74,"section":35},{"id":84,"form":66,"route":67,"label":85,"concentration":86,"markets":88,"refs":89},"bag-15","1500 mg\u002F100 mL ready-to-use IV bag (15 mg\u002FmL)",{"amount":87,"unit":29,"perVolumeMl":5},15,[16],[90],{"source":74,"section":35},[92,131,154,176],{"id":93,"disease":94,"label":95,"population":98,"type":102,"unit":29,"dose":103,"refs":108,"notes":111,"allowedFormulations":130},"adult","epilepsy",{"fa":96,"en":97},"صرع پارشیل — ۱۶ سال به بالا: ۵۰۰ mg دو بار در روز","Partial seizures — ≥16 y: 500 mg twice daily",{"minAge":99},{"value":100,"unit":101},16,"year","titration",{"dividedDoses":104,"titration":105},2,{"start":49,"increment":49,"incrementEveryDays":106,"max":107},14,3000,[109],{"source":34,"section":110},"2.2",[112,119],{"text":113,"refs":116},{"fa":114,"en":115},"افزایش ۱۰۰۰ mg\u002Fday هر ۲ هفته تا حداکثر ۳۰۰۰؛ بالاتر سودی ندارد.","Increase by 1,000 mg\u002Fday every 2 weeks up to 3,000; no added benefit above.",[117,118],{"source":34,"section":110},{"source":62,"section":110},{"text":120,"refs":123},{"fa":121,"en":122},"کیسه وریدی (۱۶ سال به بالا، وقتی خوراکی ممکن نیست): همان دوز و دفعات خوراکی، انفوزیون ۱۵ دقیقه‌ای، بدون رقیق‌سازی.","IV bag (≥16 y, when oral use is not feasible): same dose and frequency as oral, 15-minute infusion, no further dilution.",[124,126,128],{"source":74,"section":125},"1",{"source":74,"section":127},"2.1",{"source":74,"section":129},"2.3",[23,37,46,54,65,76,84],{"id":132,"disease":94,"label":133,"population":136,"type":141,"unit":29,"dose":142,"refs":144,"notes":146,"allowedFormulations":153},"1-6m",{"fa":134,"en":135},"صرع پارشیل — ۱ تا ۶ ماه: ۷ mg\u002Fkg دو بار (هدف ۲۱)","Partial seizures — 1–6 months: 7 mg\u002Fkg twice daily (target 21)",{"minAge":137,"maxAge":139},{"value":5,"unit":138},"month",{"value":140,"unit":138},6,"weightBased",{"perKgPerDay":106,"perKgPerDayMax":143,"dividedDoses":104},42,[145],{"source":62,"section":110},[147],{"text":148,"refs":151},{"fa":149,"en":150},"افزایش ۱۴ mg\u002Fkg\u002Fday هر ۲ هفته تا ۴۲ mg\u002Fkg\u002Fday. محلول خوراکی با سرنگ مدرج.","Increase by 14 mg\u002Fkg\u002Fday every 2 weeks to 42 mg\u002Fkg\u002Fday. Oral solution with a calibrated syringe.",[152],{"source":62,"section":110},[23,37,46,54],{"id":155,"disease":94,"label":156,"population":159,"type":141,"unit":29,"dose":163,"refs":166,"notes":168,"allowedFormulations":175},"6m-4y",{"fa":157,"en":158},"صرع پارشیل — ۶ ماه تا ۴ سال: ۱۰ mg\u002Fkg دو بار (هدف ۲۵)","Partial seizures — 6 months–4 y: 10 mg\u002Fkg twice daily (target 25)",{"minAge":160,"maxAge":161},{"value":140,"unit":138},{"value":162,"unit":101},4,{"perKgPerDay":164,"perKgPerDayMax":165,"dividedDoses":104},20,50,[167],{"source":62,"section":110},[169],{"text":170,"refs":173},{"fa":171,"en":172},"پس از ۲ هفته ۲۰ mg\u002Fkg\u002Fday افزایش تا ۵۰ mg\u002Fkg\u002Fday.","After 2 weeks increase by 20 mg\u002Fkg\u002Fday to 50 mg\u002Fkg\u002Fday.",[174],{"source":62,"section":110},[23,37,46,54],{"id":177,"disease":94,"label":178,"population":181,"type":141,"unit":29,"dose":184,"refs":186,"limits":188,"notes":191,"allowedFormulations":199},"4-16",{"fa":179,"en":180},"صرع پارشیل — ۴ تا ۱۵ سال: ۱۰ mg\u002Fkg دو بار (هدف ۳۰)","Partial seizures — 4–15 y: 10 mg\u002Fkg twice daily (target 30)",{"minAge":182,"maxAge":183},{"value":162,"unit":101},{"value":100,"unit":101},{"perKgPerDay":164,"perKgPerDayMax":185,"dividedDoses":104},60,[187],{"source":62,"section":110},{"maxPerDay":107,"refs":189},[190],{"source":34,"section":110},[192],{"text":193,"refs":196},{"fa":194,"en":195},"افزایش ۲۰ mg\u002Fkg\u002Fday هر ۲ هفته تا ۶۰ mg\u002Fkg\u002Fday. ۲۰ kg و کمتر: فقط محلول.","Increase by 20 mg\u002Fkg\u002Fday every 2 weeks to 60 mg\u002Fkg\u002Fday. ≤20 kg: oral solution only.",[197,198],{"source":62,"section":110},{"source":34,"section":127},[23,37,46,54],[201],{"id":202,"severity":203,"text":204,"refs":207},"ci","block",{"fa":205,"en":206},"حساسیت به لووتیراستام.","Hypersensitivity to levetiracetam.",[208],{"source":34,"section":209},"4",[],[],[],[],{"status":215,"reviewer":216,"date":216},"unverified",null,[218,223,229,233,237],{"regimen":93,"formulation":23,"input":219,"expect":222},{"ageYears":220,"weightKg":221},30,70,{"perDose":28},{"regimen":132,"formulation":54,"input":224,"expect":226},{"ageYears":225,"weightKg":70},0.25,{"perDose":227,"mlPerDose":228},35,0.35,{"regimen":155,"formulation":54,"input":230,"expect":231},{"ageYears":104,"weightKg":79},{"perDose":58,"mlPerDose":5,"upperPerDose":232},250,{"regimen":177,"formulation":54,"input":234,"expect":235},{"ageYears":140,"weightKg":164},{"perDose":236,"mlPerDose":104},200,{"regimen":177,"formulation":23,"input":238,"expect":239},{"ageYears":106,"weightKg":165},{"perDose":28,"upperPerDose":240},1500,[242],"N03AX14",{"status":244,"forms":245,"refs":290},"registered",[246,250,254,258,262,266,270,274,278,282,286],{"code":247,"en":248,"fa":249},"09533","LEVETIRACETAM 1000MG TAB","قرص لووتیراستام ۱۰۰۰ 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mg\u002F1 mL 300 mL","محلول خوراکی لووتیراستام ۱۰۰ میلی‌گرم \u002F ۱ میلی‌لیتر ۳۰۰ میلی‌لیتر",{"code":287,"en":288,"fa":289},"50472","LEVETIRACETAM INJECTION, SOLUTION PARENTERAL 5 mg\u002F1mL 100 mL","محلول تزریقی لووتیراستام ۵ میلی‌گرم \u002F ۱ میلی‌لیتر ۱۰۰ میلی‌لیتر",[291],{"source":292,"section":293,"url":294},"darooyab-generic","G-669\u002FLevetiracetam","https:\u002F\u002Fwww.darooyab.ir\u002FG-669\u002FLevetiracetam",[296,300,304,307,310,313,316,319],{"kind":297,"url":298,"label":299},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=076919","ANDA076919",{"kind":301,"url":302,"label":303},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=100d7618-b8e6-43f5-a4e2-6fd728de9d3f","FDA Levetiracetam tabs",{"kind":301,"url":305,"label":306},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f65ec19d-b90e-452e-b761-c68b1cf2c892","FDA Levetiracetam sol",{"kind":301,"url":308,"label":309},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=62f3d1c8-ca5b-4760-9fc9-41e4fb4cc926","FDA Levetiracetam IV",{"kind":311,"url":312,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa699059.html",{"kind":311,"url":314,"label":315},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa622013.html","Levetiracetam Injection",{"kind":317,"url":318,"label":242},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N03AX14",{"kind":320,"url":294,"label":8},"darooyab",{"pregnancy":322,"lactation":331,"pediatric":339,"geriatric":347},{"level":323,"text":324,"quote":327,"refs":328},"caution",{"fa":325,"en":326},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Prolonged experience with levetiracetam in pregnant women has not identified a drug-associated risk of major birth defects or miscarriage, based on published literature, which includes data from pregnancy registries and reflects experience over two decades [see Human Data ] .",[329],{"source":34,"section":330},"8.1",{"level":323,"text":332,"quote":335,"refs":336},{"fa":333,"en":334},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Levetiracetam is excreted in human milk.",[337],{"source":34,"section":338},"8.2",{"level":323,"text":340,"quote":343,"refs":344},{"fa":341,"en":342},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of levetiracetam for the treatment of partial-onset seizures in patients 1 month to 16 years of age have been established [see Clinical Pharmacology (12.3) and Clinical Studies (14.1) ] .",[345],{"source":34,"section":346},"8.4",{"level":323,"text":348,"quote":351,"refs":352},{"fa":349,"en":350},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function [see Clinical Pharmacology (12.3) ] .",[353],{"source":34,"section":354},"8.5",{"kind":356,"refs":357,"id":299},"ANDA",[358],{"source":34,"section":359},"SPL approval \u002F marketing category",1792444713894]