[{"data":1,"prerenderedAt":241},["ShallowReactive",2],{"drug-linezolid":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":100,"warnings":110,"renal":118,"monitoring":119,"interactions":120,"review":128,"examples":131,"atc":140,"iran":142,"links":174,"populations":194,"usApproval":236},"linezolid",1,{"fa":7,"en":8},"لاینزولید","Linezolid","anti-infectives",{"fa":11,"en":12},"اکسازولیدینون","Oxazolidinone",[14],{"name":15,"market":16},"Zyvox","US",[18,7,19],"zyvox","لینزولید",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-600","tablet","oral","600 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},600,"mg",false,[16],[32],{"source":33,"section":34},"fda-linezolid","3",[36,62,76],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":49,"durationDays":52,"notes":55},"adult","hospital-acquired-pneumonia",{"fa":40,"en":41},"پنومونی بیمارستانی یا اکتسابی، عفونت عارضه‌دار پوست، VRE — ۱۲ سال به بالا ۶۰۰ mg هر ۱۲ ساعت","Nosocomial or community pneumonia, cSSSI, VRE — ≥12 y 600 mg every 12 h",{"minAge":43},{"value":44,"unit":45},12,"year","fixed",{"perDose":27,"dosesPerDay":48},2,[50],{"source":33,"section":51},"2.1",{"min":53,"max":54},10,14,[56],{"text":57,"refs":60},{"fa":58,"en":59},"VRE: ۱۴ تا ۲۸ روز. عفونت پوستی بدون عارضه بزرگسال: ۴۰۰ mg هر ۱۲ ساعت (قرص ۴۰۰ در این برچسب نیست).","VRE: 14–28 days. Uncomplicated SSSI in adults: 400 mg every 12 h (no 400 mg tablet in this label).",[61],{"source":33,"section":51},{"id":63,"disease":38,"label":64,"population":67,"type":69,"unit":28,"dose":70,"refs":74},"child",{"fa":65,"en":66},"کودک زیر ۱۲ سال — ۱۰ mg\u002Fkg هر ۸ ساعت (فرم مایع)","Child \u003C12 y — 10 mg\u002Fkg every 8 h (liquid form)",{"maxAge":68},{"value":44,"unit":45},"notCalculated",{"reason":71},{"fa":72,"en":73},"برچسب: ۱۰ mg\u002Fkg هر ۸ ساعت (عفونت پوستی بدون عارضه: زیر ۵ سال هر ۸ و ۵ تا ۱۱ سال هر ۱۲ ساعت). این برچسب فقط قرص ۶۰۰ mg دارد؛ برای کودک از سوسپانسیون استفاده شود.","Label: 10 mg\u002Fkg every 8 h (uncomplicated SSSI: \u003C5 y every 8 h, 5–11 y every 12 h). This label only has the 600 mg tablet; children need the oral suspension.",[75],{"source":33,"section":51},{"id":77,"disease":78,"label":79,"population":82,"type":46,"unit":28,"dose":84,"refs":85,"durationDays":87,"notes":88},"dfi","diabetic-foot-infection",{"fa":80,"en":81},"عفونت پای دیابتی بدون استئومیلیت — ۱۲ سال به بالا ۶۰۰ mg هر ۱۲ ساعت","Diabetic foot infection without osteomyelitis — ≥12 y 600 mg every 12 h",{"minAge":83},{"value":44,"unit":45},{"perDose":27,"dosesPerDay":48},[86],{"source":33,"section":51},{"min":53,"max":54},[89,93],{"text":90,"refs":91},{"fa":58,"en":59},[92],{"source":33,"section":51},{"text":94,"refs":97},{"fa":95,"en":96},"برچسب: عفونت عارضه‌دار پوست شامل پای دیابتی بدون استئومیلیت همزمان.","Label: complicated skin infections including diabetic foot infections without concomitant osteomyelitis.",[98],{"source":33,"section":99},"1",[101],{"id":102,"severity":103,"text":104,"refs":107},"ci","block",{"fa":105,"en":106},"حساسیت به لاینزولید؛ مصرف MAOI یا ظرف ۲ هفته پس از آن.","Hypersensitivity to linezolid; MAOIs now or within 2 weeks.",[108],{"source":33,"section":109},"4",[111],{"text":112,"refs":115},{"fa":113,"en":114},"سرکوب مغز استخوان (CBC هفتگی)؛ سندرم سروتونین با داروهای سروتونرژیک؛ نوروپاتی محیطی و بینایی در مصرف بیش از ۲۸ روز؛ اسیدوز لاکتیک؛ هیپوگلیسمی.","Myelosuppression (weekly CBC); serotonin syndrome with serotonergic drugs; peripheral and optic neuropathy beyond 28 days; lactic acidosis; hypoglycaemia.",[116],{"source":33,"section":117},"5",[],[],[121],{"with":122,"text":123,"refs":126},"ssri",{"fa":124,"en":125},"SSRI، SNRI، تریپتان‌ها و سایر داروهای سروتونرژیک: سندرم سروتونین.","SSRIs, SNRIs, triptans and other serotonergic drugs: serotonin syndrome.",[127],{"source":33,"section":117},{"status":129,"reviewer":130,"date":130},"unverified",null,[132,137],{"regimen":37,"formulation":22,"input":133,"expect":136},{"ageYears":134,"weightKg":135},50,70,{"perDose":27,"tabletsPerDoseRounded":5},{"regimen":77,"formulation":22,"input":138,"expect":139},{"ageYears":134,"weightKg":135},{"perDose":27,"tabletsPerDoseRounded":5},[141],"J01XX08",{"status":143,"forms":144,"refs":169},"registered",[145,149,153,157,161,165],{"code":146,"en":147,"fa":148},"09250","LINEZOLID 2mg\u002Fml 300ML SOLUTION","محلول لاینزولید ۲ میلی‌گرم \u002F میلی‌لیتر ۳۰۰ میلی‌لیتر",{"code":150,"en":151,"fa":152},"21942","LINEZOLID 400MG TAB","قرص لاینزولید ۴۰۰ میلی‌گرم",{"code":154,"en":155,"fa":156},"08301","LINEZOLID 600MG INJ","فرآورده تزریقی لاینزولید ۶۰۰ میلی‌گرم",{"code":158,"en":159,"fa":160},"08300","LINEZOLID 600MG TAB","قرص لاینزولید ۶۰۰ میلی‌گرم",{"code":162,"en":163,"fa":164},"50114","LINEZOLID INJECTION, SOLUTION PARENTERAL 2 mg\u002F1mL 300 mL","محلول تزریقی لاینزولید ۲ میلی‌گرم \u002F ۱ میلی‌لیتر ۳۰۰ میلی‌لیتر",{"code":166,"en":167,"fa":168},"52928","LINEZOLID INJECTION, SOLUTION PARENTERAL 2 mg\u002F1mL 100 mL","محلول تزریقی لاینزولید ۲ میلی‌گرم \u002F ۱ میلی‌لیتر ۱۰۰ میلی‌لیتر",[170],{"source":171,"section":172,"url":173},"darooyab-generic","G-423\u002FLinezolid","https:\u002F\u002Fwww.darooyab.ir\u002FG-423\u002FLinezolid",[175,179,183,186,189,192],{"kind":176,"url":177,"label":178},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=078845","ANDA078845",{"kind":180,"url":181,"label":182},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=bf4fa35d-93c9-41c3-a2ae-0298014b8a9f","FDA Linezolid tab",{"kind":184,"url":185,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa602004.html",{"kind":184,"url":187,"label":188},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa612002.html","Linezolid Injection",{"kind":190,"url":191,"label":141},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01XX08",{"kind":193,"url":173,"label":8},"darooyab",{"pregnancy":195,"lactation":204,"pediatric":212,"geriatric":220,"reproductive":228},{"level":196,"text":197,"quote":200,"refs":201},"caution",{"fa":198,"en":199},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from published and postmarketing case reports with linezolid use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.",[202],{"source":33,"section":203},"8.1",{"level":196,"text":205,"quote":208,"refs":209},{"fa":206,"en":207},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Linezolid is present in breast milk.",[210],{"source":33,"section":211},"8.2",{"level":196,"text":213,"quote":216,"refs":217},{"fa":214,"en":215},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","… y in patients ranging in age from 8 months through 12 years) • vancomycin-resistant Enterococcus faecium infections The safety and effectiveness of linezolid for the treatment of pediatric patients with the following infection have been established in a comparator-controlled study in pediatric patients ranging in …",[218],{"source":33,"section":219},"8.4",{"level":196,"text":221,"quote":224,"refs":225},{"fa":222,"en":223},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Of the 2,046 patients treated with linezolid in Phase 3 comparator-controlled clinical trials, 589 (29%) were 65 years or older and 253 (12%) were 75 years or older.",[226],{"source":33,"section":227},"8.5",{"level":196,"text":229,"quote":232,"refs":233},{"fa":230,"en":231},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Males Based on findings from studies in rats, linezolid may reversibly impair fertility in male patients [ see Nonclinical Toxicology (13.1) ].",[234],{"source":33,"section":235},"8.3",{"kind":237,"refs":238,"id":178},"ANDA",[239],{"source":33,"section":240},"SPL approval \u002F marketing category",1792191874182]