[{"data":1,"prerenderedAt":261},["ShallowReactive",2],{"drug-lorazepam":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":69,"contraindications":128,"warnings":164,"renal":165,"monitoring":166,"interactions":167,"review":168,"examples":171,"atc":184,"iran":186,"links":210,"populations":230,"usApproval":256},"lorazepam",1,{"fa":7,"en":8},"لورازپام","Lorazepam","nervous-system",{"fa":11,"en":12},"بنزودیازپین","Benzodiazepine",[14],{"name":15,"market":16},"Ativan","US",[18,19,7],"ativan","آتیوان",[21,35,42,50,61],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-0-5","tablet","oral","0.5 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},0.5,"mg",false,[16],[32],{"source":33,"section":34},"fda-lorazepam","Dosage and Administration",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":39,"refs":40},"tab-1","1 mg tablet",{"amount":5,"unit":28,"perUnit":23,"scored":29},[16],[41],{"source":33,"section":34},{"id":43,"form":23,"route":24,"label":44,"concentration":45,"markets":47,"refs":48},"tab-2","2 mg tablet",{"amount":46,"unit":28,"perUnit":23,"scored":29},2,[16],[49],{"source":33,"section":34},{"id":51,"form":52,"route":53,"label":54,"concentration":55,"markets":56,"refs":57},"inj-2","injection","iv","2 mg\u002FmL injection",{"amount":46,"unit":28,"perVolumeMl":5},[16],[58],{"source":59,"section":60},"fda-lorazepam-inj","How Supplied",{"id":62,"form":52,"route":53,"label":63,"concentration":64,"markets":66,"refs":67},"inj-4","4 mg\u002FmL injection",{"amount":65,"unit":28,"perVolumeMl":5},4,[16],[68],{"source":59,"section":60},[70,95,106],{"id":71,"disease":71,"label":72,"population":75,"type":79,"unit":28,"dose":80,"refs":81,"limits":83,"notes":87,"allowedFormulations":94},"anxiety",{"fa":73,"en":74},"اضطراب — شروع ۲ تا ۳ mg\u002Fday در ۲ یا ۳ نوبت","Anxiety — start 2–3 mg\u002Fday in 2 or 3 doses",{"minAge":76},{"value":77,"unit":78},12,"year","fixed",{"perDose":5,"dosesPerDay":46},[82],{"source":33,"section":34},{"maxPerDay":84,"refs":85},10,[86],{"source":33,"section":34},[88],{"text":89,"refs":92},{"fa":90,"en":91},"معمول ۲ تا ۶ mg\u002Fday منقسم (بیشترین دوز شب)؛ محدوده ۱ تا ۱۰. سالمند: شروع ۱ تا ۲ mg\u002Fday.","Usual 2–6 mg\u002Fday divided (largest at bedtime); range 1–10. Elderly: start 1–2 mg\u002Fday.",[93],{"source":33,"section":34},[22,36,43],{"id":96,"disease":96,"label":97,"population":100,"type":79,"unit":28,"dose":102,"refs":103,"allowedFormulations":105},"insomnia",{"fa":98,"en":99},"بی‌خوابی ناشی از اضطراب — ۲ تا ۴ mg شب","Insomnia due to anxiety — 2–4 mg at bedtime",{"minAge":101},{"value":77,"unit":78},{"perDose":46,"perDoseMax":65,"dosesPerDay":5},[104],{"source":33,"section":34},[22,36,43],{"id":107,"disease":108,"label":109,"population":112,"type":79,"unit":28,"dose":115,"refs":116,"durationDays":119,"allowedFormulations":120,"notes":121},"se","status-epilepticus",{"fa":110,"en":111},"صرع پایدار — ۱۸ سال به بالا: ۴ mg وریدی آهسته (۲ mg\u002Fmin)","Status epilepticus — ≥18 y: 4 mg IV slowly (2 mg\u002Fmin)",{"minAge":113},{"value":114,"unit":78},18,{"perDose":65,"dosesPerDay":5},[117],{"source":59,"section":118},"Dosage and Administration — Status Epilepticus",{"min":5,"max":5},[51,62],[122],{"text":123,"refs":126},{"fa":124,"en":125},"اگر تشنج پس از ۱۰ تا ۱۵ دقیقه ادامه یافت یا برگشت، یک دوز دیگر ۴ mg آهسته. تجربه با دوزهای بیشتر بسیار محدود. وسایل حفظ راه هوایی در دسترس باشد. ایمنی در کودکان ثابت نشده.","If seizures continue or recur after 10–15 min, one more 4 mg dose slowly. Very limited experience with further doses. Airway equipment must be at hand. Safety in children not established.",[127],{"source":59,"section":118},[129,138,148,157],{"id":130,"severity":131,"text":132,"refs":135},"ci","block",{"fa":133,"en":134},"حساسیت به بنزودیازپین‌ها؛ گلوکوم زاویه بسته حاد.","Hypersensitivity to benzodiazepines; acute narrow-angle glaucoma.",[136],{"source":33,"section":137},"Contraindications",{"id":139,"severity":131,"rule":140,"text":142,"refs":145},"under-12",{"maxAge":141},{"value":77,"unit":78},{"fa":143,"en":144},"زیر ۱۲ سال ثابت نشده.","Not established in children under 12.",[146],{"source":33,"section":147},"Pediatric Use",{"id":149,"severity":150,"text":151,"refs":154},"boxed","warn",{"fa":152,"en":153},"هشدار جعبه‌ای: مصرف همزمان با اپیوئیدها (دپرسیون تنفسی و مرگ)؛ سوءمصرف و وابستگی؛ علائم ترک با قطع ناگهانی.","Boxed warning: concomitant opioids (respiratory depression, death); abuse, misuse and dependence; withdrawal on abrupt stop.",[155],{"source":33,"section":156},"Boxed Warning",{"id":158,"severity":131,"text":159,"refs":162},"inj-ci",{"fa":160,"en":161},"تزریقی: گلوکوم زاویه بسته حاد، آپنه خواب، نارسایی شدید تنفسی (جز بیمار تحت تهویه)، تزریق داخل شریانی، نوزاد نارس (بنزیل الکل).","Injection: acute narrow-angle glaucoma, sleep apnoea, severe respiratory insufficiency (except ventilated patients), intra-arterial injection, premature infants (benzyl alcohol).",[163],{"source":59,"section":137},[],[],[],[],{"status":169,"reviewer":170,"date":170},"unverified",null,[172,177,181],{"regimen":71,"formulation":36,"input":173,"expect":176},{"ageYears":174,"weightKg":175},35,70,{"perDose":5,"perDay":46},{"regimen":96,"formulation":43,"input":178,"expect":180},{"ageYears":179,"weightKg":175},40,{"perDose":46,"upperPerDose":65},{"regimen":107,"formulation":51,"input":182,"expect":183},{"ageYears":179,"weightKg":175},{"perDose":65,"mlPerDose":46},[185],"N05BA06",{"status":187,"forms":188,"refs":205},"registered",[189,193,197,201],{"code":190,"en":191,"fa":192},"00771","LORAZEPAM 1MG TAB","قرص لورازپام ۱ میلی‌گرم",{"code":194,"en":195,"fa":196},"00772","LORAZEPAM 2MG TAB","قرص لورازپام ۲ میلی‌گرم",{"code":198,"en":199,"fa":200},"01575","LORAZEPAM 2MG\u002FML AMP","آمپول لورازپام ۲ میلی‌گرم \u002F میلی‌لیتر",{"code":202,"en":203,"fa":204},"01576","LORAZEPAM 4MG\u002FML AMP","آمپول لورازپام ۴ میلی‌گرم \u002F میلی‌لیتر",[206],{"source":207,"section":208,"url":209},"darooyab-generic","G-1295\u002FLorazepam","https:\u002F\u002Fwww.darooyab.ir\u002FG-1295\u002FLorazepam",[211,215,219,222,225,228],{"kind":212,"url":213,"label":214},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=078203","ANDA078203",{"kind":216,"url":217,"label":218},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=1009c870-fd98-4e3b-81c8-4184036fb8c2","FDA Lorazepam",{"kind":216,"url":220,"label":221},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=20140b19-846b-425f-b191-670e17809945","FDA Lorazepam inj.",{"kind":223,"url":224,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682053.html",{"kind":226,"url":227,"label":185},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05BA06",{"kind":229,"url":209,"label":8},"darooyab",{"pregnancy":231,"lactation":240,"geriatric":248},{"level":232,"text":233,"quote":236,"refs":237},"caution",{"fa":234,"en":235},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Neonates born to mothers using benzodiazepines late in pregnancy have been reported to experience symptoms of sedation and\u002For neonatal withdrawal (see WARNINGS: Neonatal Sedation and Withdrawal Syndrome and Clinical Considerations ).",[238],{"source":33,"section":239},"Pregnancy",{"level":232,"text":241,"quote":244,"refs":245},{"fa":242,"en":243},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Lorazepam is present in breast milk.",[246],{"source":33,"section":247},"Nursing Mothers",{"level":232,"text":249,"quote":252,"refs":253},{"fa":250,"en":251},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, and lower doses may be sufficient in these patients (see DOSAGE AND ADMINISTRATION ).",[254],{"source":33,"section":255},"Geriatric Use",{"kind":257,"refs":258,"id":214},"ANDA",[259],{"source":33,"section":260},"SPL approval \u002F marketing category",1792440739420]