[{"data":1,"prerenderedAt":243},["ShallowReactive",2],{"drug-losartan":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":52,"contraindications":105,"warnings":124,"renal":132,"monitoring":140,"interactions":141,"review":142,"examples":145,"atc":161,"iran":163,"links":187,"populations":204,"usApproval":238},"losartan",1,{"fa":7,"en":8},"لوزارتان","Losartan","cardiovascular",{"fa":11,"en":12},"مسدودکننده گیرنده آنژیوتانسین (ARB)","Angiotensin receptor blocker",[14],{"name":15,"market":16},"Cozaar","US",[7,18,19],"cozaar","ARB",[21,35,44],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-25","tablet","oral","25 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},25,"mg",false,[16],[32],{"source":33,"section":34},"fda-losartan","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":41,"refs":42},"tab-50","50 mg tablet (scored)",{"amount":39,"unit":28,"perUnit":23,"scored":40},50,true,[16],[43],{"source":33,"section":34},{"id":45,"form":23,"route":24,"label":46,"concentration":47,"markets":49,"refs":50},"tab-100","100 mg tablet",{"amount":48,"unit":28,"perUnit":23,"scored":29},100,[16],[51],{"source":33,"section":34},[53,87],{"id":54,"disease":55,"label":56,"population":59,"type":65,"unit":28,"dose":66,"refs":69,"limits":74,"notes":80},"htn-child","hypertension",{"fa":57,"en":58},"فشار خون کودکان ۶ تا ۱۶ سال — ۰٫۷ mg\u002Fkg یک‌بار در روز (تا ۵۰ mg)","Pediatric hypertension 6–16 y — 0.7 mg\u002Fkg once daily (up to 50 mg)",{"minAge":60,"maxAge":63},{"value":61,"unit":62},6,"year",{"value":64,"unit":62},17,"weightBased",{"perKgPerDose":67,"intervalHours":68},0.7,24,[70,72],{"source":33,"section":71},"2.1",{"source":33,"section":73},"8.4",{"maxPerDose":39,"refs":75},[76],{"source":33,"section":71,"note":77},{"fa":78,"en":79},"دوز شروع حداکثر ۵۰ mg","Starting dose up to 50 mg total",[81],{"text":82,"refs":85},{"fa":83,"en":84},"بر اساس پاسخ فشار تنظیم شود؛ بالای ۱.۴ mg\u002Fkg یا ۱۰۰ mg در روز در کودکان مطالعه نشده.","Adjust to blood pressure; doses above 1.4 mg\u002Fkg or 100 mg\u002Fday not studied in children.",[86],{"source":33,"section":71},{"id":88,"disease":55,"label":89,"population":92,"type":94,"unit":28,"dose":95,"refs":96,"notes":98},"htn-adult",{"fa":90,"en":91},"بزرگسال — شروع ۵۰ mg روزانه (حداکثر ۱۰۰ mg)","Adults — start 50 mg daily (max 100 mg)",{"minAge":93},{"value":64,"unit":62},"fixed",{"perDose":39,"perDoseMax":48,"dosesPerDay":5},[97],{"source":33,"section":71},[99],{"text":100,"refs":103},{"fa":101,"en":102},"در کاهش حجم داخل عروقی (مثلاً مصرف دیورتیک) شروع با ۲۵ mg.","Start 25 mg with possible intravascular depletion (e.g. diuretics).",[104],{"source":33,"section":71},[106,115],{"id":107,"severity":108,"text":109,"refs":112},"aliskiren","block",{"fa":110,"en":111},"حساسیت؛ مصرف همزمان آلیسکیرن در دیابت.","Hypersensitivity; coadministration with aliskiren in diabetes.",[113],{"source":33,"section":114},"4",{"id":116,"severity":108,"rule":117,"text":119,"refs":122},"under-6",{"maxAge":118},{"value":61,"unit":62},{"fa":120,"en":121},"بی‌خطری زیر ۶ سال ثابت نشده است.","Not established under 6 years.",[123],{"source":33,"section":73},[125],{"text":126,"refs":129},{"fa":127,"en":128},"هشدار جعبه‌ای: سمیت جنینی؛ با تشخیص بارداری قطع شود.","Boxed warning: fetal toxicity; discontinue when pregnancy is detected.",[130],{"source":33,"section":131},"WARNING: FETAL TOXICITY",[133],{"egfrBelow":134,"severity":108,"text":135,"refs":138},30,{"fa":136,"en":137},"در کودکان با GFR کمتر از ۳۰ توصیه نمی‌شود.","Not recommended in pediatric patients with GFR \u003C30.",[139],{"source":33,"section":73},[],[],{"status":143,"reviewer":144,"date":144},"unverified",null,[146,152,157],{"regimen":54,"formulation":22,"input":147,"expect":150},{"ageYears":148,"weightKg":149},12,36,{"perDose":151,"tabletsPerDoseRounded":5},25.2,{"regimen":54,"formulation":22,"input":153,"expect":155},{"ageYears":154,"weightKg":134},10,{"status":156},"blocked",{"regimen":88,"formulation":36,"input":158,"expect":160},{"ageYears":39,"weightKg":159},80,{"perDose":39,"upperPerDose":48},[162],"C09CA01",{"status":164,"forms":165,"refs":182},"registered",[166,170,174,178],{"code":167,"en":168,"fa":169},"06214","LOSARTAN 20MG CAP","کپسول لوزارتان ۲۰ میلی‌گرم",{"code":171,"en":172,"fa":173},"12796","LOSARTAN POTASSIUM 100MG TAB","قرص لوزارتان پتاسیم ۱۰۰ میلی‌گرم",{"code":175,"en":176,"fa":177},"01822","LOSARTAN POTASSIUM 25MG TAB","قرص لوزارتان پتاسیم ۲۵ میلی‌گرم",{"code":179,"en":180,"fa":181},"01933","LOSARTAN POTASSIUM 50MG TAB","قرص لوزارتان پتاسیم ۵۰ میلی‌گرم",[183],{"source":184,"section":185,"url":186},"darooyab-generic","G-1743\u002FLosartan","https:\u002F\u002Fwww.darooyab.ir\u002FG-1743\u002FLosartan",[188,192,196,199,202],{"kind":189,"url":190,"label":191},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=203030","ANDA203030",{"kind":193,"url":194,"label":195},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=92691768-b5e6-4527-98dc-d86c58f6f13e","FDA Losartan",{"kind":197,"url":198,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa695008.html",{"kind":200,"url":201,"label":162},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C09CA01",{"kind":203,"url":186,"label":8},"darooyab",{"pregnancy":205,"lactation":214,"pediatric":223,"geriatric":230},{"level":206,"text":207,"quote":210,"refs":211},"avoid",{"fa":208,"en":209},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","WARNING: FETAL TOXICITY See full prescribing information for complete boxed warning.",[212],{"source":33,"section":213},"Boxed Warning",{"level":215,"text":216,"quote":219,"refs":220},"caution",{"fa":217,"en":218},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.",[221],{"source":33,"section":222},"8.2",{"level":215,"text":224,"quote":227,"refs":228},{"fa":225,"en":226},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness have not been established in pediatric patients under the age of 6 or in pediatric patients with glomerular filtration rate \u003C30 mL\u002Fmin\u002F1.73 m 2 [see Dosage and Administration (2.1) , Clinical Pharmacology (12.3) , and Clinical Studies (14.1) ] .",[229],{"source":33,"section":73},{"level":215,"text":231,"quote":234,"refs":235},{"fa":232,"en":233},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In a controlled clinical study for the reduction in the combined risk of cardiovascular death, stroke and myocardial infarction in hypertensive patients with left ventricular hypertrophy, 2857 patients (62%) were 65 years and over, while 808 patients (18%) were 75 years and over.",[236],{"source":33,"section":237},"8.5",{"kind":239,"refs":240,"id":191},"ANDA",[241],{"source":33,"section":242},"SPL approval \u002F marketing category",1792440728095]