[{"data":1,"prerenderedAt":195},["ShallowReactive",2],{"drug-memantine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":44,"contraindications":68,"warnings":78,"renal":79,"monitoring":80,"interactions":81,"review":82,"examples":85,"atc":92,"iran":94,"links":138,"populations":155,"usApproval":190},"memantine",1,{"fa":7,"en":8},"ممانتین","Memantine","nervous-system",{"fa":11,"en":12},"آنتاگونیست NMDA","NMDA antagonist",[14],{"name":15,"market":16},"Namenda","US",[18,19,7,20],"namenda","نامندا","آلزایمر",[22,36],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-5","tablet","oral","5 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},5,"mg",false,[16],[33],{"source":34,"section":35},"fda-memantine","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-10","10 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},10,[16],[43],{"source":34,"section":35},[45],{"id":46,"disease":47,"label":48,"population":51,"type":55,"unit":29,"dose":56,"refs":58,"notes":61},"ad","alzheimers",{"fa":49,"en":50},"آلزایمر متوسط تا شدید — دوز هدف ۱۰ mg دو بار (پس از تیتراسیون)","Moderate–severe Alzheimer’s — target 10 mg twice daily (after titration)",{"minAge":52},{"value":53,"unit":54},18,"year","fixed",{"perDose":40,"dosesPerDay":57},2,[59],{"source":34,"section":60},"2",[62],{"text":63,"refs":66},{"fa":64,"en":65},"شروع ۵ mg یک بار؛ افزایش ۵ mg (حداقل یک هفته فاصله): ۱۰ mg\u002Fday (۵ دو بار)، ۱۵ (۵ و ۱۰)، ۲۰ (۱۰ دو بار).","Start 5 mg once daily; increase in 5 mg steps at least 1 week apart: 10 mg\u002Fday (5 twice), 15 (5 + 10), 20 (10 twice).",[67],{"source":34,"section":60},[69],{"id":70,"severity":71,"text":72,"refs":75},"ci","block",{"fa":73,"en":74},"حساسیت به ممانتین.","Hypersensitivity to memantine.",[76],{"source":34,"section":77},"4",[],[],[],[],{"status":83,"reviewer":84,"date":84},"unverified",null,[86],{"regimen":46,"formulation":37,"input":87,"expect":90},{"ageYears":88,"weightKg":89},75,65,{"perDose":40,"perDay":91},20,[93],"N06DX01",{"status":95,"forms":96,"refs":133},"registered",[97,101,105,109,113,117,121,125,129],{"code":98,"en":99,"fa":100},"05917","MEMANTINE 10MG TAB","قرص ممانتین ۱۰ میلی‌گرم",{"code":102,"en":103,"fa":104},"09393","MEMANTINE 10MG\u002FG 50G DROP","قطره ممانتین ۱۰ میلی‌گرم \u002F گرم ۵۰ گرم",{"code":106,"en":107,"fa":108},"17956","MEMANTINE 20MG TAB","قرص ممانتین ۲۰ میلی‌گرم",{"code":110,"en":111,"fa":112},"21178","MEMANTINE 2MG\u002FML ORAL SOLUTION","محلول خوراکی ممانتین ۲ میلی‌گرم \u002F میلی‌لیتر",{"code":114,"en":115,"fa":116},"09203","MEMANTINE 5MG TAB","قرص ممانتین ۵ میلی‌گرم",{"code":118,"en":119,"fa":120},"51380","MEMANTINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE ORAL 14 mg","کپسول آهسته‌رهش ممانتین هیدروکلراید ۱۴ میلی‌گرم",{"code":122,"en":123,"fa":124},"51644","MEMANTINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE ORAL 21 mg","کپسول آهسته‌رهش ممانتین هیدروکلراید ۲۱ میلی‌گرم",{"code":126,"en":127,"fa":128},"53065","MEMANTINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE ORAL 7 mg","کپسول آهسته‌رهش ممانتین هیدروکلراید ۷ میلی‌گرم",{"code":130,"en":131,"fa":132},"53066","MEMANTINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE ORAL 28 mg","کپسول آهسته‌رهش ممانتین هیدروکلراید ۲۸ میلی‌گرم",[134],{"source":135,"section":136,"url":137},"darooyab-generic","G-4000\u002FMemantine","https:\u002F\u002Fwww.darooyab.ir\u002FG-4000\u002FMemantine",[139,143,147,150,153],{"kind":140,"url":141,"label":142},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=212947","ANDA212947",{"kind":144,"url":145,"label":146},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=30b4d5c4-0a31-c385-e063-6394a90adbce","FDA Memantine",{"kind":148,"url":149,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa604006.html",{"kind":151,"url":152,"label":93},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06DX01",{"kind":154,"url":137,"label":8},"darooyab",{"pregnancy":156,"lactation":165,"pediatric":173,"geriatric":182},{"level":157,"text":158,"quote":161,"refs":162},"caution",{"fa":159,"en":160},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate data on the developmental risk associated with the use of memantine hydrochloride in pregnant women.",[163],{"source":34,"section":164},"8.1",{"level":157,"text":166,"quote":169,"refs":170},{"fa":167,"en":168},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of memantine in human milk, the effects on the breastfed infant, or the effects of memantine hydrochloride on milk production.",[171],{"source":34,"section":172},"8.2",{"level":174,"text":175,"quote":178,"refs":179},"not-established",{"fa":176,"en":177},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[180],{"source":34,"section":181},"8.4",{"level":157,"text":183,"quote":186,"refs":187},{"fa":184,"en":185},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","The majority of people with Alzheimer’s disease are 65 years and older.",[188],{"source":34,"section":189},"8.5",{"kind":191,"refs":192,"id":142},"ANDA",[193],{"source":34,"section":194},"SPL approval \u002F marketing category",1792191879281]