[{"data":1,"prerenderedAt":249},["ShallowReactive",2],{"drug-mesalamine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":38,"contraindications":68,"warnings":88,"renal":89,"monitoring":90,"interactions":91,"review":92,"examples":95,"atc":102,"iran":104,"links":188,"populations":210,"usApproval":244},"mesalamine",1,{"fa":7,"en":8},"مزالازین","Mesalamine (mesalazine)","alimentary-metabolism",{"fa":11,"en":12},"آمینوسالیسیلات","Aminosalicylate",[14],{"name":15,"market":16},"Asacol HD","US",[18,19,20,21,7,22],"asacol","پنتاسا","pentasa","مزالامین","mesalazine",[24],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"tab-800","tablet","oral","800 mg tablet",{"amount":30,"unit":31,"perUnit":26,"scored":32},800,"mg",false,[16],[35],{"source":36,"section":37},"fda-mesalamine","3",[39],{"id":40,"disease":41,"label":42,"population":45,"type":49,"unit":31,"dose":50,"refs":53,"durationDays":56,"notes":58},"uc","ulcerative-colitis",{"fa":43,"en":44},"کولیت اولسراتیو متوسط فعال — ۱۶۰۰ mg سه بار، ۶ هفته","Moderately active UC — 1,600 mg three times daily for 6 weeks",{"minAge":46},{"value":47,"unit":48},18,"year","fixed",{"perDose":51,"dosesPerDay":52},1600,3,[54],{"source":36,"section":55},"2.2",{"min":57,"max":57},42,[59],{"text":60,"refs":63},{"fa":61,"en":62},"یک قرص ۸۰۰ mg جایگزین دو قرص ۴۰۰ mg نشود. پیش از شروع کارکرد کلیه بررسی شود.","Do not substitute one 800 mg tablet for two 400 mg products. Check renal function first.",[64,66],{"source":36,"section":65},"2.1",{"source":36,"section":67},"2",[69,78],{"id":70,"severity":71,"text":72,"refs":75},"ci","block",{"fa":73,"en":74},"حساسیت به سالیسیلات‌ها یا آمینوسالیسیلات‌ها.","Hypersensitivity to salicylates or aminosalicylates.",[76],{"source":36,"section":77},"4",{"id":79,"severity":71,"rule":80,"text":82,"refs":85},"child",{"maxAge":81},{"value":47,"unit":48},{"fa":83,"en":84},"این فرآورده در کودکان ثابت نشده.","This product not established in children.",[86],{"source":36,"section":87},"8.4",[],[],[],[],{"status":93,"reviewer":94,"date":94},"unverified",null,[96],{"regimen":40,"formulation":25,"input":97,"expect":100},{"ageYears":98,"weightKg":99},35,70,{"perDose":51,"tabletsPerDoseRounded":101},2,[103],"A07EC02",{"status":105,"forms":106,"refs":183},"registered",[107,111,115,119,123,127,131,135,139,143,147,151,155,159,163,167,171,175,179],{"code":108,"en":109,"fa":110},"06168","MESALASINE 1000MG ENEMA","انما مسالاسین ۱۰۰۰ میلی‌گرم",{"code":112,"en":113,"fa":114},"11655","MESALAZINE 1000MG SUPP","شیاف مزالازین ۱۰۰۰ میلی‌گرم",{"code":116,"en":117,"fa":118},"02443","MESALAZINE 1G\u002FSACHET GRANULE","ساشه مزالازین ۱ گرم",{"code":120,"en":121,"fa":122},"01728","MESALAZINE 250MG EC TAB","قرص انتریک‌کوتد مزالازین ۲۵۰ میلی‌گرم",{"code":124,"en":125,"fa":126},"00812","MESALAZINE 400MG TAB","قرص مزالازین ۴۰۰ میلی‌گرم",{"code":128,"en":129,"fa":130},"00785","MESALAZINE 4G ENEMA","انما مزالازین ۴ گرم",{"code":132,"en":133,"fa":134},"02246","MESALAZINE 500MG SUPP","شیاف مزالازین ۵۰۰ میلی‌گرم",{"code":136,"en":137,"fa":138},"00813","MESALAZINE 500MG TAB","قرص مزالازین ۵۰۰ میلی‌گرم",{"code":140,"en":141,"fa":142},"01867","MESALAZINE 50MG SUPP","شیاف مزالازین ۵۰ میلی‌گرم",{"code":144,"en":145,"fa":146},"09916","MESALAZINE 800MG TAB","قرص مزالازین ۸۰۰ میلی‌گرم",{"code":148,"en":149,"fa":150},"02155","MESALAZINE SR 250MG TAB","قرص آهسته‌رهش مزالازین ۲۵۰ میلی‌گرم",{"code":152,"en":153,"fa":154},"02156","MESALAZINE SR 500MG TAB","قرص آهسته‌رهش مزالازین ۵۰۰ میلی‌گرم",{"code":156,"en":157,"fa":158},"50426","MESALAZINE CAPSULE, EXTENDED RELEASE ORAL 500 mg","کپسول آهسته‌رهش مزالازین ۵۰۰ میلی‌گرم",{"code":160,"en":161,"fa":162},"50022","MESALAZINE GRANULE, EXTENDED RELEASE ORAL 2 g","گرانول آهسته‌رهش مزالازین ۲ گرم",{"code":164,"en":165,"fa":166},"52302","MESALAZINE TABLET, EXTENDED RELEASE ORAL 1 g","قرص آهسته‌رهش مزالازین ۱ گرم",{"code":168,"en":169,"fa":170},"52146","MESALAZINE ENEMA RECTAL 1 g\u002F100mL","انما مزالازین ۱ گرم \u002F ۱۰۰ میلی‌لیتر",{"code":172,"en":173,"fa":174},"52236","MESALAZINE GRANULE, EXTENDED RELEASE ORAL 4 g","گرانول آهسته‌رهش مزالازین ۴ گرم",{"code":176,"en":177,"fa":178},"52672","MESALAZINE TABLET, EXTENDED RELEASE ORAL 1200 mg","قرص آهسته‌رهش مزالازین ۱۲۰۰ میلی‌گرم",{"code":180,"en":181,"fa":182},"52885","MESALAZINE TABLET, EXTENDED RELEASE ORAL 1600 mg","قرص آهسته‌رهش مزالازین ۱۶۰۰ میلی‌گرم",[184],{"source":185,"section":186,"url":187},"darooyab-generic","G-2613\u002FMesalazine","https:\u002F\u002Fwww.darooyab.ir\u002FG-2613\u002FMesalazine",[189,193,197,201,204,207],{"kind":190,"url":191,"label":192},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=203286","ANDA203286",{"kind":194,"url":195,"label":196},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=ad8c7930-92e2-4372-a874-da22b9ae333e","FDA Mesalamine DR",{"kind":198,"url":199,"label":200},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa688021.html","Mesalamine",{"kind":198,"url":202,"label":203},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa614021.html","Mesalamine Rectal",{"kind":205,"url":206,"label":103},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A07EC02",{"kind":208,"url":187,"label":209},"darooyab","Mesalazine",{"pregnancy":211,"lactation":220,"pediatric":228,"geriatric":236},{"level":212,"text":213,"quote":216,"refs":217},"caution",{"fa":214,"en":215},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Limited published data on mesalamine use in pregnant women are insufficient to inform a drug-associated risk.",[218],{"source":36,"section":219},"8.1",{"level":212,"text":221,"quote":224,"refs":225},{"fa":222,"en":223},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Mesalamine and its N-acetyl metabolite are present in human milk in undetectable to small amounts [ see Data ].",[226],{"source":36,"section":227},"8.2",{"level":229,"text":230,"quote":233,"refs":234},"not-established",{"fa":231,"en":232},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness of mesalamine in pediatric patients have not been established.",[235],{"source":36,"section":87},{"level":212,"text":237,"quote":240,"refs":241},{"fa":238,"en":239},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Monitor complete blood cell counts and platelet counts in elderly patients during therapy with mesalamine delayed-release tablets.",[242],{"source":36,"section":243},"8.5",{"kind":245,"refs":246,"id":192},"ANDA",[247],{"source":36,"section":248},"SPL approval \u002F marketing category",1792191867288]