[{"data":1,"prerenderedAt":220},["ShallowReactive",2],{"drug-methimazole":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":24,"regimens":47,"contraindications":123,"warnings":133,"renal":134,"monitoring":135,"interactions":136,"review":137,"examples":140,"atc":159,"iran":161,"links":173,"populations":190,"usApproval":215},"methimazole",1,{"fa":7,"en":8},"متی‌مازول","Methimazole","systemic-hormones",{"fa":11,"en":12},"ضدتیروئید","Antithyroid",[14],{"name":15,"market":16},"Tapazole","US",[18,19,20,21,22,23],"tapazole","تاپازول","متیمازول","متی مازول","thiamazole","تیامازول",[25,39],{"id":26,"form":27,"route":28,"label":29,"concentration":30,"markets":34,"refs":35},"tab-5","tablet","oral","5 mg tablet (scored)",{"amount":31,"unit":32,"perUnit":27,"scored":33},5,"mg",true,[16],[36],{"source":37,"section":38},"fda-methimazole","How Supplied",{"id":40,"form":27,"route":28,"label":41,"concentration":42,"markets":44,"refs":45},"tab-10","10 mg tablet (scored)",{"amount":43,"unit":32,"perUnit":27,"scored":33},10,[16],[46],{"source":37,"section":38},[48,71,86,102],{"id":49,"disease":50,"label":51,"population":54,"type":58,"unit":32,"dose":59,"refs":61,"notes":64},"mild","hyperthyroidism",{"fa":52,"en":53},"پرکاری خفیف — بزرگسال: ۱۵ mg\u002Fday در ۳ نوبت","Mild hyperthyroidism — adults: 15 mg\u002Fday in 3 doses",{"minAge":55},{"value":56,"unit":57},18,"year","fixed",{"perDose":31,"dosesPerDay":60},3,[62],{"source":37,"section":63},"Dosage and Administration",[65],{"text":66,"refs":69},{"fa":67,"en":68},"هر ۸ ساعت. نگهدارنده ۵ تا ۱۵ mg\u002Fday.","Every 8 hours. Maintenance 5–15 mg\u002Fday.",[70],{"source":37,"section":63},{"id":72,"disease":50,"label":73,"population":76,"type":58,"unit":32,"dose":78,"refs":79,"notes":81},"moderate",{"fa":74,"en":75},"پرکاری متوسط تا شدید — بزرگسال: ۳۰ mg\u002Fday در ۳ نوبت (تا ۴۰)","Moderately severe — adults: 30 mg\u002Fday in 3 doses (up to 40)",{"minAge":77},{"value":56,"unit":57},{"perDose":43,"dosesPerDay":60},[80],{"source":37,"section":63},[82],{"text":83,"refs":84},{"fa":67,"en":68},[85],{"source":37,"section":63},{"id":87,"disease":50,"label":88,"population":91,"type":58,"unit":32,"dose":93,"refs":95,"notes":97},"severe",{"fa":89,"en":90},"پرکاری شدید — بزرگسال: ۶۰ mg\u002Fday در ۳ نوبت","Severe — adults: 60 mg\u002Fday in 3 doses",{"minAge":92},{"value":56,"unit":57},{"perDose":94,"dosesPerDay":60},20,[96],{"source":37,"section":63},[98],{"text":99,"refs":100},{"fa":67,"en":68},[101],{"source":37,"section":63},{"id":103,"disease":50,"label":104,"population":107,"type":109,"unit":32,"dose":110,"refs":112,"notes":114},"peds",{"fa":105,"en":106},"کودکان: ۰٫۴ mg\u002Fkg\u002Fday در ۳ نوبت","Children: 0.4 mg\u002Fkg\u002Fday in 3 doses",{"maxAge":108},{"value":56,"unit":57},"weightBased",{"perKgPerDay":111,"dividedDoses":60},0.4,[113],{"source":37,"section":63},[115],{"text":116,"refs":119},{"fa":117,"en":118},"هر ۸ ساعت. نگهدارنده تقریباً نصف دوز اولیه. در کودکان متی‌مازول بر PTU ترجیح دارد.","Every 8 hours. Maintenance about half the initial dose. Methimazole is preferred over PTU in children.",[120,121],{"source":37,"section":63},{"source":37,"section":122},"Pediatric Use",[124],{"id":125,"severity":126,"text":127,"refs":130},"ci","block",{"fa":128,"en":129},"حساسیت به دارو.","Hypersensitivity to the drug.",[131],{"source":37,"section":132},"Contraindications",[],[],[],[],{"status":138,"reviewer":139,"date":139},"unverified",null,[141,147,151,155],{"regimen":49,"formulation":26,"input":142,"expect":145},{"ageYears":143,"weightKg":144},40,65,{"perDose":31,"perDay":146},15,{"regimen":72,"formulation":40,"input":148,"expect":149},{"ageYears":143,"weightKg":144},{"perDay":150},30,{"regimen":87,"formulation":40,"input":152,"expect":153},{"ageYears":143,"weightKg":144},{"tabletsPerDoseRounded":154},2,{"regimen":103,"formulation":26,"input":156,"expect":158},{"ageYears":43,"weightKg":157},37.5,{"perDose":31,"perDay":146},[160],"H03BB02",{"status":162,"forms":163,"refs":168},"registered",[164],{"code":165,"en":166,"fa":167},"00821","METHIMAZOLE 5MG TAB","قرص متیمازول ۵ میلی‌گرم",[169],{"source":170,"section":171,"url":172},"darooyab-generic","G-3419\u002FMethimazole","https:\u002F\u002Fwww.darooyab.ir\u002FG-3419\u002FMethimazole",[174,178,182,185,188],{"kind":175,"url":176,"label":177},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=040547","ANDA040547",{"kind":179,"url":180,"label":181},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=06bb4bcc-5e47-48b6-a76c-648f846704e8","FDA Methimazole",{"kind":183,"url":184,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682464.html",{"kind":186,"url":187,"label":160},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=H03BB02",{"kind":189,"url":172,"label":8},"darooyab",{"pregnancy":191,"lactation":200,"pediatric":208},{"level":192,"text":193,"quote":196,"refs":197},"caution",{"fa":194,"en":195},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","[See WARNINGS .] If methimazole tablets are used during the first trimester of pregnancy or if the patient becomes pregnant while taking this drug, the patient should be warned of the potential hazard to the fetus.",[198],{"source":37,"section":199},"Pregnancy",{"level":192,"text":201,"quote":204,"refs":205},{"fa":202,"en":203},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Methimazole is present in breast milk.",[206],{"source":37,"section":207},"Nursing Mothers",{"level":192,"text":209,"quote":212,"refs":213},{"fa":210,"en":211},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Because of postmarketing reports of severe liver injury in pediatric patients treated with propylthiouracil, methimazole is the preferred choice when an antithyroid drug is required for a pediatric patient [see DOSAGE AND ADMINISTRATION ] .",[214],{"source":37,"section":122},{"kind":216,"refs":217,"id":177},"ANDA",[218],{"source":37,"section":219},"SPL approval \u002F marketing category",1792191871993]