[{"data":1,"prerenderedAt":229},["ShallowReactive",2],{"drug-metoclopramide":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":20,"formulations":24,"regimens":38,"contraindications":91,"warnings":110,"renal":123,"monitoring":132,"interactions":133,"review":134,"examples":137,"atc":154,"iran":156,"links":180,"populations":196},"metoclopramide",1,{"fa":7,"en":8},"متوکلوپرامید","Metoclopramide","alimentary-metabolism",{"fa":11,"en":12},"آنتاگونیست دوپامین؛ پروکینتیک","Dopamine antagonist; prokinetic",[14,17],{"name":15,"market":16},"Reglan","US",{"name":18,"market":19},"Maxolon","GB",[21,22,23],"plasil","پلاسیل","متوکلوپرامید قطره",[25],{"id":26,"form":27,"route":28,"label":29,"concentration":30,"markets":33,"refs":34},"sol-5-5","solution","oral","5 mg \u002F 5 mL oral solution",{"amount":31,"unit":32,"perVolumeMl":31},5,"mg",[19],[35],{"source":36,"section":37},"uk-smpc-metoclopramide","1",[39,72],{"id":40,"disease":41,"label":42,"population":45,"type":50,"unit":32,"dose":51,"refs":55,"limits":58,"durationDays":62,"notes":63},"cinv-child","cinv",{"fa":43,"en":44},"پیشگیری از تهوع تأخیری شیمی‌درمانی — ۱ تا ۱۸ سال: ۰٫۱ تا ۰٫۱۵ mg\u002Fkg تا ۳ بار در روز","Prevention of delayed CINV — 1–18 years: 0.1–0.15 mg\u002Fkg up to 3 times daily",{"minAge":46,"maxAge":48},{"value":5,"unit":47},"year",{"value":49,"unit":47},18,"weightBased",{"perKgPerDose":52,"perKgPerDoseMax":53,"intervalHours":54},0.1,0.15,8,[56],{"source":36,"section":57},"4.2",{"maxPerKgPerDay":59,"refs":60},0.5,[61],{"source":36,"section":57},{"min":5,"max":31},[64],{"text":65,"refs":68},{"fa":66,"en":67},"حداقل ۶ ساعت فاصله بین دو دوز، حتی اگر استفراغ شود. حداکثر ۵ روز. در کودکان فقط برای این کاربرد مجوز دارد.","At least 6 h between doses, even after vomiting. Maximum 5 days. In children licensed only for this use.",[69,70],{"source":36,"section":57},{"source":36,"section":71},"4.4",{"id":73,"disease":74,"label":75,"population":78,"type":80,"unit":32,"dose":81,"refs":84,"limits":86,"durationDays":90},"adult","nausea-vomiting",{"fa":76,"en":77},"بزرگسال — ۱۰ mg تا ۳ بار در روز","Adults — 10 mg up to 3 times daily",{"minAge":79},{"value":49,"unit":47},"fixed",{"perDose":82,"dosesPerDay":83},10,3,[85],{"source":36,"section":57},{"maxPerDay":87,"maxPerKgPerDay":59,"refs":88},30,[89],{"source":36,"section":57},{"min":5,"max":31},[92,103],{"id":93,"severity":94,"rule":95,"text":97,"refs":100},"under-1-year","block",{"maxAge":96},{"value":5,"unit":47},{"fa":98,"en":99},"کودکان زیر ۱ سال (خطر اختلالات اکستراپیرامیدال).","Children under 1 year (risk of extrapyramidal disorders).",[101],{"source":36,"section":102},"4.3",{"id":104,"severity":94,"text":105,"refs":108},"other",{"fa":106,"en":107},"خونریزی، انسداد یا سوراخ شدن گوارش؛ سابقه دیسکینزی دیررس؛ صرع؛ پارکینسون؛ فئوکروموسیتوم؛ همراه لوودوپا\u002Fآگونیست دوپامین؛ سابقه مت‌هموگلوبینمی.","GI haemorrhage, obstruction or perforation; history of tardive dyskinesia; epilepsy; Parkinson's disease; phaeochromocytoma; with levodopa\u002Fdopamine agonists; history of methaemoglobinaemia.",[109],{"source":36,"section":102},[111,117],{"text":112,"refs":115},{"fa":113,"en":114},"عوارض اکستراپیرامیدال به‌ویژه در کودکان و جوانان، حتی پس از یک دوز؛ در صورت بروز فوراً قطع شود.","Extrapyramidal disorders, particularly in children and young adults, even after a single dose; stop immediately if they occur.",[116],{"source":36,"section":71},{"text":118,"refs":121},{"fa":119,"en":120},"دیسکینزی دیررس با مصرف طولانی؛ بیش از ۳ ماه مصرف نشود. سندرم نورولپتیک بدخیم.","Tardive dyskinesia with prolonged use; do not exceed 3 months. Neuroleptic malignant syndrome.",[122],{"source":36,"section":71},[124],{"egfrBelow":125,"severity":126,"text":127,"refs":130},60,"warn",{"fa":128,"en":129},"کلیرانس ۱۵ تا ۶۰: دوز ۵۰٪ کاهش؛ ۱۵ یا کمتر: دوز روزانه ۷۵٪ کاهش.","CrCl 15–60: reduce dose 50%; ≤15: reduce daily dose 75%.",[131],{"source":36,"section":57},[],[],{"status":135,"reviewer":136,"date":136},"unverified",null,[138,146,150],{"regimen":40,"formulation":26,"input":139,"expect":142},{"ageYears":140,"weightKg":141},4,15,{"perDose":143,"mlPerDose":143,"upperPerDose":144,"upperPerDay":145},1.5,2.25,6.75,{"regimen":40,"formulation":26,"input":147,"expect":148},{"ageMonths":54,"weightKg":54},{"status":149},"blocked",{"regimen":73,"formulation":26,"input":151,"expect":153},{"ageYears":87,"weightKg":152},70,{"perDose":82,"mlPerDose":82,"perDay":87},[155],"A03FA01",{"status":157,"forms":158,"refs":175},"registered",[159,163,167,171],{"code":160,"en":161,"fa":162},"18780","METOCLOPRAMIDE 10MG SOFT GEL CAP","کپسول نرم متوکلوپرامید ۱۰ میلی‌گرم",{"code":164,"en":165,"fa":166},"00841","METOCLOPRAMIDE 10MG TAB","قرص متوکلوپرامید ۱۰ میلی‌گرم",{"code":168,"en":169,"fa":170},"00839","METOCLOPRAMIDE 10MG\u002F2ML AMP","آمپول متوکلوپرامید ۱۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":172,"en":173,"fa":174},"00840","METOCLOPRAMIDE 4MG\u002FML 15ML ORAL DROP","قطره خوراکی متوکلوپرامید ۴ میلی‌گرم \u002F میلی‌لیتر ۱۵ میلی‌لیتر",[176],{"source":177,"section":178,"url":179},"darooyab-generic","G-2614\u002FMetoclopramide","https:\u002F\u002Fwww.darooyab.ir\u002FG-2614\u002FMetoclopramide",[181,184,187,190,192],{"kind":182,"url":183,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa684035.html",{"kind":182,"url":185,"label":186},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601158.html","Metoclopramide Injection",{"kind":188,"url":189,"label":155},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A03FA01",{"kind":191,"url":179,"label":8},"darooyab",{"kind":193,"url":194,"label":195},"emc","https:\u002F\u002Fwww.medicines.org.uk\u002Femc\u002Fproduct\u002F2471\u002Fsmpc","UK SmPC Metoclopramide",{"pregnancy":197,"lactation":206,"pediatric":214,"geriatric":222},{"level":198,"text":199,"quote":202,"refs":203},"avoid",{"fa":200,"en":201},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Metoclopramide should be avoided at the end of pregnancy.",[204],{"source":36,"section":205},"4.6",{"level":207,"text":208,"quote":211,"refs":212},"caution",{"fa":209,"en":210},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Metoclopramide is excreted in breast milk at low level.",[213],{"source":36,"section":205},{"level":215,"text":216,"quote":219,"refs":220},"contraindicated",{"fa":217,"en":218},"برچسب: در کودکان زیر سن مشخص منع مصرف دارد.","Label: contraindicated in children below a stated age.","…  section 4.5). • Known history of methaemoglobinaemia with metoclopramide or of NADH cytochrome-b5 deficiency. • Use in children less than 1 year of age due to an increased risk of extrapyramidal disorders (see section 4.4).",[221],{"source":36,"section":102},{"level":207,"text":223,"quote":226,"refs":227},{"fa":224,"en":225},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Elderly In elderly patients a dose reduction should be considered, based on renal and hepatic function and overall frailty.",[228],{"source":36,"section":57},1792191867063]