[{"data":1,"prerenderedAt":274},["ShallowReactive",2],{"drug-metoprolol":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":52,"contraindications":136,"warnings":146,"renal":147,"monitoring":148,"interactions":149,"review":150,"examples":153,"atc":165,"iran":167,"links":207,"populations":228,"usApproval":269},"metoprolol",1,{"fa":7,"en":8},"متوپرولول","Metoprolol tartrate","cardiovascular",{"fa":11,"en":12},"بتابلاکر انتخابی β1","Beta-1 selective blocker",[14],{"name":15,"market":16},"Lopressor","US",[18,19,7,20],"lopressor","لوپرسور","metoprolol tartrate",[22,36,44],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-25","tablet","oral","25 mg tablet (scored)",{"amount":28,"unit":29,"perUnit":24,"scored":30},25,"mg",true,[16],[33],{"source":34,"section":35},"fda-metoprolol","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-50","50 mg tablet (scored)",{"amount":40,"unit":29,"perUnit":24,"scored":30},50,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-100","100 mg tablet (scored)",{"amount":48,"unit":29,"perUnit":24,"scored":30},100,[16],[51],{"source":34,"section":35},[53,80,102,121],{"id":54,"disease":55,"label":56,"population":59,"type":63,"unit":29,"dose":64,"refs":66,"limits":69,"notes":73},"htn","hypertension",{"fa":57,"en":58},"فشار خون — بزرگسال: ۱۰۰ mg\u002Fday (یک یا دو نوبت)","Hypertension — adults: 100 mg\u002Fday (single or divided)",{"minAge":60},{"value":61,"unit":62},18,"year","fixed",{"perDose":40,"dosesPerDay":65},2,[67],{"source":34,"section":68},"2.1",{"maxPerDay":70,"refs":71},450,[72],{"source":34,"section":68},[74],{"text":75,"refs":78},{"fa":76,"en":77},"محدوده مؤثر ۱۰۰ تا ۴۵۰ mg\u002Fday؛ بالاتر از ۴۵۰ مطالعه نشده. با غذا.","Effective range 100–450 mg\u002Fday; above 450 not studied. With food.",[79],{"source":34,"section":68},{"id":81,"disease":81,"label":82,"population":85,"type":63,"unit":29,"dose":87,"refs":88,"limits":91,"notes":95},"angina",{"fa":83,"en":84},"آنژین — بزرگسال: ۱۰۰ mg\u002Fday در دو نوبت","Angina — adults: 100 mg\u002Fday in two doses",{"minAge":86},{"value":61,"unit":62},{"perDose":40,"dosesPerDay":65},[89],{"source":34,"section":90},"2.2",{"maxPerDay":92,"refs":93},400,[94],{"source":34,"section":90},[96],{"text":97,"refs":100},{"fa":98,"en":99},"محدوده ۱۰۰ تا ۴۰۰ mg\u002Fday.","Range 100–400 mg\u002Fday.",[101],{"source":34,"section":90},{"id":103,"disease":104,"label":105,"population":108,"type":63,"unit":29,"dose":110,"refs":111,"notes":114},"post-mi","acute-coronary-syndrome",{"fa":106,"en":107},"پس از MI — نگهدارنده ۱۰۰ mg دو بار در روز","Post-MI — maintenance 100 mg twice daily",{"minAge":109},{"value":61,"unit":62},{"perDose":48,"dosesPerDay":65},[112],{"source":34,"section":113},"2.3",[115],{"text":116,"refs":119},{"fa":117,"en":118},"پس از دوز وریدی: ۵۰ mg هر ۶ ساعت به مدت ۴۸ ساعت، سپس ۱۰۰ mg دو بار. درمان ۱ تا ۳ سال ادامه یابد.","After the IV dose: 50 mg every 6 h for 48 h, then 100 mg twice daily. Continue 1–3 years.",[120],{"source":34,"section":113},{"id":122,"disease":55,"label":123,"population":126,"type":128,"unit":29,"dose":129,"refs":133},"peds",{"fa":124,"en":125},"زیر ۱۸ سال","Under 18 years",{"maxAge":127},{"value":61,"unit":62},"notCalculated",{"reason":130},{"fa":131,"en":132},"بی‌خطری و اثربخشی در کودکان ثابت نشده است.","Safety and effectiveness in pediatric patients not established.",[134],{"source":34,"section":135},"8.4",[137],{"id":138,"severity":139,"text":140,"refs":143},"ci","block",{"fa":141,"en":142},"برادی‌کاردی شدید، بلوک درجه ۲ یا ۳، شوک کاردیوژنیک، فشار سیستولیک \u003C۱۰۰، نارسایی قلبی جبران‌نشده، سندرم سینوس بیمار (بدون پیس‌میکر)، حساسیت.","Severe bradycardia, second- or third-degree block, cardiogenic shock, systolic BP \u003C100, decompensated heart failure, sick sinus syndrome (no pacemaker), hypersensitivity.",[144],{"source":34,"section":145},"4",[],[],[],[],{"status":151,"reviewer":152,"date":152},"unverified",null,[154,158,162],{"regimen":54,"formulation":37,"input":155,"expect":157},{"ageYears":40,"weightKg":156},80,{"perDose":40,"perDay":48},{"regimen":81,"formulation":37,"input":159,"expect":161},{"ageYears":160,"weightKg":156},60,{"tabletsPerDoseRounded":5},{"regimen":103,"formulation":45,"input":163,"expect":164},{"ageYears":160,"weightKg":156},{"perDose":48},[166],"C07AB02",{"status":168,"forms":169,"refs":202},"registered",[170,174,178,182,186,190,194,198],{"code":171,"en":172,"fa":173},"11873","METOPROLOL SUCCINATE 190MG TAB","قرص متوپرولول سوکسینات ۱۹۰ میلی‌گرم",{"code":175,"en":176,"fa":177},"16112","METOPROLOL SUCCINATE 23.75MG TAB","قرص متوپرولول سوکسینات ۲۳٫۷۵ میلی‌گرم",{"code":179,"en":180,"fa":181},"11871","METOPROLOL SUCCINATE 47.5MG TAB","قرص متوپرولول سوکسینات ۴۷٫۵ میلی‌گرم",{"code":183,"en":184,"fa":185},"11872","METOPROLOL SUCCINATE 95MG TAB","قرص متوپرولول سوکسینات ۹۵ میلی‌گرم",{"code":187,"en":188,"fa":189},"02036","METOPROLOL TARTRATE 100MG TAB","قرص متوپرولول تارتارات ۱۰۰ میلی‌گرم",{"code":191,"en":192,"fa":193},"08514","METOPROLOL TARTRATE 200MG SR TAB","قرص آهسته‌رهش متوپرولول تارتارات ۲۰۰ میلی‌گرم",{"code":195,"en":196,"fa":197},"02319","METOPROLOL TARTRATE 50MG TAB","قرص متوپرولول تارتارات ۵۰ میلی‌گرم",{"code":199,"en":200,"fa":201},"02073","METOPROLOL TARTRATE 5MG\u002F5ML AMP","آمپول متوپرولول تارتارات ۵ میلی‌گرم \u002F ۵ میلی‌لیتر",[203],{"source":204,"section":205,"url":206},"darooyab-generic","G-1767\u002FMetoprolol","https:\u002F\u002Fwww.darooyab.ir\u002FG-1767\u002FMetoprolol",[208,212,216,220,223,226],{"kind":209,"url":210,"label":211},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=202871","ANDA202871",{"kind":213,"url":214,"label":215},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=5b0b19b1-4c3c-4ecb-8153-8c58ba29e5ee","FDA Metoprolol tartrate",{"kind":217,"url":218,"label":219},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682571.html","Hydrochlorothiazide",{"kind":217,"url":221,"label":222},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682864.html","Metoprolol",{"kind":224,"url":225,"label":166},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C07AB02",{"kind":227,"url":206,"label":222},"darooyab",{"pregnancy":229,"lactation":238,"pediatric":246,"geriatric":253,"reproductive":261},{"level":230,"text":231,"quote":234,"refs":235},"caution",{"fa":232,"en":233},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from published observational studies have not demonstrated an association of adverse developmental outcomes with maternal use of metoprolol during pregnancy ( see Data).",[236],{"source":34,"section":237},"8.1",{"level":230,"text":239,"quote":242,"refs":243},{"fa":240,"en":241},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Limited available data from published literature report that metoprolol is present in human milk.",[244],{"source":34,"section":245},"8.2",{"level":230,"text":247,"quote":250,"refs":251},{"fa":248,"en":249},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness of metoprolol tartrate have not been established in pediatric patients.",[252],{"source":34,"section":135},{"level":230,"text":254,"quote":257,"refs":258},{"fa":255,"en":256},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Clinical studies of metoprolol tartrate in hypertension did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.",[259],{"source":34,"section":260},"8.5",{"level":230,"text":262,"quote":265,"refs":266},{"fa":263,"en":264},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","In animal fertility studies, metoprolol has been associated with reversible adverse effects on spermatogenesis starting at oral dose level of 3.5 mg\u002Fkg in rats, which would correspond to a dose of 34 mg\u002Fday in humans in mg\u002Fm 2 equivalent, although other studies have shown no effect of metoprolol on reproductive …",[267],{"source":34,"section":268},"8.3",{"kind":270,"refs":271,"id":211},"ANDA",[272],{"source":34,"section":273},"SPL approval \u002F marketing category",1792191869949]