[{"data":1,"prerenderedAt":388},["ShallowReactive",2],{"drug-metronidazole":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":55,"contraindications":187,"warnings":211,"renal":226,"monitoring":227,"interactions":228,"review":229,"examples":232,"atc":272,"iran":274,"links":325,"populations":348,"usApproval":383},"metronidazole",1,{"fa":7,"en":8},"مترونیدازول","Metronidazole","antiparasitic",{"fa":11,"en":12},"نیتروایمیدازول؛ ضدتک‌یاخته و ضدبی‌هوازی","Nitroimidazole antiprotozoal\u002Fantibacterial",[14],{"name":15,"market":16},"Flagyl","US",[18,19,7],"فلاژیل","flagyl",[21,35,44],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-250","tablet","oral","250 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},250,"mg",false,[16],[32],{"source":33,"section":34},"fda-metronidazole-tab","Description",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-500","500 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},500,[16],[42],{"source":33,"section":43},"How Supplied",{"id":45,"form":46,"route":47,"label":48,"concentration":49,"markets":51,"refs":52},"iv-5","injection","iv","500 mg \u002F 100 mL (5 mg\u002FmL) IV infusion",{"amount":50,"unit":28,"perVolumeMl":5},5,[16],[53],{"source":54,"section":43},"fda-metroiv",[56,86,100,120,139,153,175],{"id":57,"disease":58,"label":59,"population":62,"type":66,"unit":28,"dose":67,"refs":71,"durationDays":76,"notes":78,"allowedFormulations":85},"amebiasis-child","intestinal-amebiasis",{"fa":60,"en":61},"آمیبیاز (روده‌ای و آبسه کبدی) — کودکان: ۳۵ تا ۵۰ mg\u002Fkg\u002Fday در ۳ نوبت، ۱۰ روز","Amebiasis — children: 35–50 mg\u002Fkg\u002Fday in 3 doses, 10 days",{"maxAge":63},{"value":64,"unit":65},18,"year","weightBased",{"perKgPerDay":68,"perKgPerDayMax":69,"dividedDoses":70},35,50,3,[72,74],{"source":33,"section":73},"Dosage and Administration",{"source":33,"section":75},"Pediatric Use",{"min":77,"max":77},10,[79],{"text":80,"refs":83},{"fa":81,"en":82},"فقط برای آمیبیاز در کودکان بی‌خطری ثابت شده است. شکل مایع در این برچسب نیست.","In children safety is established only for amebiasis. No liquid form in this label.",[84],{"source":33,"section":75},[22,36],{"id":87,"disease":58,"label":88,"population":91,"type":93,"unit":28,"dose":94,"refs":96,"durationDays":98,"allowedFormulations":99},"amebiasis-adult",{"fa":89,"en":90},"آمیبیاز روده‌ای حاد — بزرگسال: ۷۵۰ mg سه بار در روز","Acute intestinal amebiasis — adults: 750 mg three times daily",{"minAge":92},{"value":64,"unit":65},"fixed",{"perDose":95,"dosesPerDay":70},750,[97],{"source":33,"section":73},{"min":50,"max":77},[22,36],{"id":101,"disease":102,"label":103,"population":106,"type":66,"unit":28,"dose":108,"refs":111,"limits":113,"durationDays":117,"allowedFormulations":119},"anaerobic-adult","serious-anaerobic-infection",{"fa":104,"en":105},"عفونت بی‌هوازی جدی — بزرگسال: ۷٫۵ mg\u002Fkg هر ۶ ساعت","Serious anaerobic infection — adults: 7.5 mg\u002Fkg every 6 h",{"minAge":107},{"value":64,"unit":65},{"perKgPerDose":109,"intervalHours":110},7.5,6,[112],{"source":33,"section":73},{"maxPerDay":114,"refs":115},4000,[116],{"source":33,"section":73},{"min":118,"max":77},7,[22,36],{"id":121,"disease":102,"label":122,"population":125,"type":66,"unit":28,"dose":127,"refs":129,"allowedFormulations":131,"notes":132},"iv-load",{"fa":123,"en":124},"عفونت بی‌هوازی شدید — بارگذاری ۱۵ mg\u002Fkg وریدی طی ۱ ساعت","Serious anaerobic infection — loading 15 mg\u002Fkg IV over 1 h",{"minAge":126},{"value":64,"unit":65},{"perKgPerDay":128,"dividedDoses":5},15,[130],{"source":54,"section":73},[45],[133],{"text":134,"refs":137},{"fa":135,"en":136},"حدود ۱ g برای ۷۰ kg؛ ۶ ساعت بعد نگهدارنده.","About 1 g for 70 kg; maintenance starts 6 h later.",[138],{"source":54,"section":73},{"id":140,"disease":102,"label":141,"population":144,"type":66,"unit":28,"dose":146,"refs":147,"limits":149,"allowedFormulations":152},"iv-maint",{"fa":142,"en":143},"نگهدارنده — ۷٫۵ mg\u002Fkg وریدی هر ۶ ساعت","Maintenance — 7.5 mg\u002Fkg IV every 6 h",{"minAge":145},{"value":64,"unit":65},{"perKgPerDose":109,"intervalHours":110},[148],{"source":54,"section":73},{"maxPerDay":114,"refs":150},[151],{"source":54,"section":73},[45],{"id":154,"disease":155,"label":156,"population":159,"type":93,"unit":28,"dose":161,"refs":162,"durationDays":165,"allowedFormulations":166,"notes":167},"liver-abscess-adult","amebic-liver-abscess",{"fa":157,"en":158},"آبسه کبدی آمیبی — بزرگسال: ۵۰۰ یا ۷۵۰ mg سه بار در روز، ۵ تا ۱۰ روز","Amoebic liver abscess — adult: 500 or 750 mg three times daily, 5–10 days",{"minAge":160},{"value":64,"unit":65},{"perDose":39,"perDoseMax":95,"dosesPerDay":70},[163],{"source":33,"section":164},"Dosage and Administration — Amebiasis",{"min":50,"max":77},[22,36],[168],{"text":169,"refs":172},{"fa":170,"en":171},"درمان دارویی جای آسپیراسیون یا درناژ چرک را نمی‌گیرد.","Drug therapy does not replace aspiration or drainage of pus.",[173],{"source":33,"section":174},"Indications and Usage — Amebiasis",{"id":176,"disease":155,"label":177,"population":180,"type":66,"unit":28,"dose":182,"refs":183,"durationDays":185,"allowedFormulations":186},"liver-abscess-child",{"fa":178,"en":179},"آبسه کبدی آمیبی — کودک: ۳۵ تا ۵۰ mg\u002Fkg\u002Fروز در ۳ دوز، ۱۰ روز","Amoebic liver abscess — child: 35–50 mg\u002Fkg\u002Fday in 3 doses, 10 days",{"maxAge":181},{"value":64,"unit":65},{"perKgPerDay":68,"perKgPerDayMax":69,"dividedDoses":70},[184],{"source":33,"section":164},{"min":77,"max":77},[22,36],[188,197,204],{"id":189,"severity":190,"text":191,"refs":194},"hypersensitivity","block",{"fa":192,"en":193},"حساسیت به مترونیدازول یا سایر نیتروایمیدازول‌ها.","Hypersensitivity to metronidazole or other nitroimidazoles.",[195],{"source":33,"section":196},"Contraindications",{"id":198,"severity":190,"text":199,"refs":202},"disulfiram-alcohol",{"fa":200,"en":201},"مصرف دی‌سولفیرام در ۲ هفته اخیر؛ الکل یا پروپیلن گلیکول تا ۳ روز پس از درمان.","Disulfiram within the last two weeks; alcohol or propylene glycol during and for 3 days after therapy.",[203],{"source":33,"section":196},{"id":205,"severity":190,"text":206,"refs":209},"cockayne",{"fa":207,"en":208},"سندرم کاکاین (نارسایی کبدی کشنده).","Cockayne syndrome (fatal hepatotoxicity).",[210],{"source":33,"section":196},[212,219],{"text":213,"refs":216},{"fa":214,"en":215},"هشدار جعبه‌ای: در موش و رت سرطان‌زا؛ از مصرف غیرضروری پرهیز شود.","Boxed warning: carcinogenic in mice and rats; avoid unnecessary use.",[217],{"source":33,"section":218},"WARNING (boxed)",{"text":220,"refs":223},{"fa":221,"en":222},"واکنش‌های شدید پوستی (SJS، TEN، DRESS)؛ انسفالوپاتی و نوروپاتی محیطی؛ تشنج.","Severe cutaneous reactions (SJS, TEN, DRESS); encephalopathy and peripheral neuropathy; seizures.",[224],{"source":33,"section":225},"Warnings",[],[],[],{"status":230,"reviewer":231,"date":231},"unverified",null,[233,237,243,248,252,258,262,265],{"regimen":57,"formulation":22,"input":234,"expect":235},{"ageYears":50,"weightKg":64},{"status":236},"blocked",{"regimen":57,"formulation":22,"input":238,"expect":241},{"ageYears":239,"weightKg":240},8,21.4,{"perDose":242,"tabletsPerDoseRounded":5},249.67,{"regimen":87,"formulation":22,"input":244,"expect":247},{"ageYears":245,"weightKg":246},30,70,{"tabletsPerDoseRounded":70},{"regimen":101,"formulation":36,"input":249,"expect":250},{"ageYears":245,"weightKg":246},{"perDose":251},525,{"regimen":121,"formulation":45,"input":253,"expect":255},{"ageYears":254,"weightKg":246},40,{"perDose":256,"mlPerDose":257},1050,210,{"regimen":140,"formulation":45,"input":259,"expect":260},{"ageYears":254,"weightKg":246},{"perDose":251,"mlPerDose":261},105,{"regimen":154,"formulation":22,"input":263,"expect":264},{"ageYears":254,"weightKg":246},{"perDose":39,"upperPerDose":95},{"regimen":176,"formulation":22,"input":266,"expect":269},{"ageYears":267,"weightKg":268},13,43,{"perDose":270,"upperPerDose":271},501.67,716.67,[273],"P01AB01",{"status":275,"forms":276,"refs":320},"registered",[277,281,285,289,293,297,301,305,309,312,316],{"code":278,"en":279,"fa":280},"02074","METRONIDAZOLE 0.75% VAG GEL","ژل واژینال مترونیدازول ۰٫۷۵ درصد",{"code":282,"en":283,"fa":284},"01590","METRONIDAZOLE 0.75%TOP GEL","ژل موضعی مترونیدازول ۰٫۷۵ درصد",{"code":286,"en":287,"fa":288},"12496","METRONIDAZOLE 200MG  TAB","قرص مترونیدازول ۲۰۰ میلی‌گرم",{"code":290,"en":291,"fa":292},"00845","METRONIDAZOLE 250MG TAB","قرص مترونیدازول ۲۵۰ میلی‌گرم",{"code":294,"en":295,"fa":296},"02162","METRONIDAZOLE 500MG OVULE","مترونیدازول ۵۰۰ میلی‌گرم اوول",{"code":298,"en":299,"fa":300},"12912","METRONIDAZOLE 500MG VAG SUPP","شیاف مترونیدازول ۵۰۰ میلی‌گرم",{"code":302,"en":303,"fa":304},"00846","METRONIDAZOLE 500MG VAG TAB","قرص واژینال مترونیدازول ۵۰۰ میلی‌گرم",{"code":306,"en":307,"fa":308},"00843","METRONIDAZOLE 500MG\u002F100ML VIAL P-BAG","ویال مترونیدازول ۵۰۰ میلی‌گرم \u002F ۱۰۰ میلی‌لیتر",{"code":310,"en":311,"fa":308},"08243","METRONIDAZOLE 500MG\u002F100ML VIAL P-BOTTLE",{"code":313,"en":314,"fa":315},"00844","METRONIDAZOLE BENZOATE 125MG\u002F5ML 120ML SUSP","سوسپانسیون مترونیدازول بنزوات ۱۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":317,"en":318,"fa":319},"51656","METRONIDAZOLE 500MG TAB","قرص مترونیدازول ۵۰۰ میلی‌گرم",[321],{"source":322,"section":323,"url":324},"darooyab-generic","G-1131\u002FMetronidazole","https:\u002F\u002Fwww.darooyab.ir\u002FG-1131\u002FMetronidazole",[326,330,334,337,340,343,346],{"kind":327,"url":328,"label":329},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=070772","ANDA070772",{"kind":331,"url":332,"label":333},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=9ed89bfc-ccf3-4e6c-924f-2a14bf82163f","FDA Metronidazole",{"kind":331,"url":335,"label":336},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=e4ea0c09-cdd1-4708-962c-6ba28b989df3","FDA Metronidazole inj.",{"kind":338,"url":339,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa689011.html",{"kind":338,"url":341,"label":342},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601159.html","Metronidazole Injection",{"kind":344,"url":345,"label":273},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=P01AB01",{"kind":347,"url":324,"label":8},"darooyab",{"pregnancy":349,"lactation":358,"pediatric":367,"geriatric":375},{"level":350,"text":351,"quote":354,"refs":355},"contraindicated",{"fa":352,"en":353},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","In patients with trichomoniasis, metronidazole tablets, USP are contraindicated during the first trimester of pregnancy (see PRECAUTIONS ).",[356],{"source":33,"section":357},"CONTRAINDICATIONS",{"level":359,"text":360,"quote":363,"refs":364},"caution",{"fa":361,"en":362},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Metronidazole is present in human milk at concentrations similar to maternal serum levels, and infant serum levels can be close to or comparable to infant therapeutic levels.",[365],{"source":33,"section":366},"Nursing Mothers",{"level":368,"text":369,"quote":372,"refs":373},"not-established",{"fa":370,"en":371},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established, except for the treatment of amebiasis.",[374],{"source":33,"section":75},{"level":359,"text":376,"quote":379,"refs":380},{"fa":377,"en":378},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In elderly geriatric patients, monitoring for metronidazole associated adverse events is recommended (see CLINICAL PHARMACOLOGY , PRECAUTIONS ).",[381],{"source":33,"section":382},"Geriatric Use",{"kind":384,"refs":385,"id":329},"ANDA",[386],{"source":33,"section":387},"SPL approval \u002F marketing category",1792191879711]