Nitrofurantoin
نیتروفورانتوئین
🦠 Antiinfectives For Systemic UseUrinary antibacterial
Market / country: 🇺🇸 USA
Macrobid (US) · Macrodantin (US) · Furadantin (US)
🧮 Dose calculator
Urinary tract infection · Regimen source: FDA Macrobid · Dosage and Administration
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Contraindicated under 1 month (haemolytic anaemia). FDA Macrobid · Contraindications
- ⛔ Anuria, oliguria or CrCl <60 mL/min; pregnancy at term (38–42 weeks) and labour; prior nitrofurantoin cholestatic jaundice; hypersensitivity. FDA Macrobid · ContraindicationsFDA Nitrofurantoin susp · 4
Renal adjustment
- • eGFR < 60: CrCl under 60 mL/min is a contraindication. FDA Macrobid · Contraindications
Formulations
- Macrobid 100 mg capsule (monohydrate/macrocrystals) — capsule 🇺🇸 USA FDA Macrobid · How Supplied
- 25 mg capsule — capsule 🇺🇸 USA FDA Nitrofurantoin macro · How Supplied
- 50 mg capsule — capsule 🇺🇸 USA FDA Nitrofurantoin macro · How Supplied
- 100 mg capsule — capsule 🇺🇸 USA FDA Nitrofurantoin macro · How Supplied
- 25 mg/5 mL oral suspension — suspension 🇺🇸 USA FDA Nitrofurantoin susp · 3
👥 Special populations
- 🤰 PregnancyContraindicated
Label: contraindicated in pregnancy. FDA Nitrofurantoin macro · CONTRAINDICATIONS
“Because of the possibility of hemolytic anemia due to immature erythrocyte enzyme systems (glutathione instability), the drug is contraindicated in pregnant patients at term (38 to 42 weeks' gestation), during labor and delivery, or when the onset of labor is imminent.”
- 🤱 BreastfeedingDangerous / avoid
Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Nitrofurantoin macro · Precautions/Warnings – Nursing Mothers
“Because of the potential for serious adverse reactions from nitrofurantoin in nursing infants under one month of age, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother (see CONTRAINDICATIONS ).”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Nitrofurantoin macro · Precautions/Warnings – Pediatric Use
“Nitrofurantoin capsules (macrocrystals) are contraindicated in infants below the age of one month (see CONTRAINDICATIONS ).”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Nitrofurantoin macro · Precautions/Warnings – Geriatric Use
“Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA217272
- DailyMed (FDA label)FDA Nitrofurantoin macroFDA MacrobidFDA Nitrofurantoin susp
- MedlinePlus (NIH)Nitrofurantoin
- WHO ATC/DDDJ01XE01
- Darooyab (Iran)Nitrofurantoin
🇮🇷 Registered in Iran Darooyab · G-455/Nitrofurantoin
Dosage forms with Iranian generic codes, per Darooyab.
- 00907 · NITROFURANTOIN 100MG TAB · قرص نیتروفورانتوئین ۱۰۰ میلیگرم
- 11723 · NITROFURANTOIN 25MG/5ML 100ML SUSP · سوسپانسیون نیتروفورانتوئین ۲۵ میلیگرم / ۵ میلیلیتر ۱۰۰ میلیلیتر
- 00908 · NITROFURANTOIN 25MG/5ML 120ML SUSP · سوسپانسیون نیتروفورانتوئین ۲۵ میلیگرم / ۵ میلیلیتر ۱۲۰ میلیلیتر
- 11725 · NITROFURANTOIN 25MG/5ML 240ML SUSP · سوسپانسیون نیتروفورانتوئین ۲۵ میلیگرم / ۵ میلیلیتر ۲۴۰ میلیلیتر
- 11701 · NITROFURANTOIN 25MG/5ML 60ML SUSP · سوسپانسیون نیتروفورانتوئین ۲۵ میلیگرم / ۵ میلیلیتر ۶۰ میلیلیتر
- 07967 · NITROFURANTOIN 50MG CAP · کپسول نیتروفورانتوئین ۵۰ میلیگرم
- 09070 · NITROFURANTOIN 50MG/5ML 80ML SUSP · سوسپانسیون نیتروفورانتوئین ۵۰ میلیگرم / ۵ میلیلیتر ۸۰ میلیلیتر
- 51882 · NITROFURANTOIN SUSPENSION ORAL 25 mg/5mL 100 mL · سوسپانسیون خوراکی نیتروفورانتوئین ۲۵ میلیگرم / ۵ میلیلیتر ۱۰۰ میلیلیتر
- 52046 · NITROFURANTOIN SUSPENSION ORAL 10 mg/1mL 80 mL · سوسپانسیون خوراکی نیتروفورانتوئین ۱۰ میلیگرم / ۱ میلیلیتر ۸۰ میلیلیتر
- 52089 · NITROFURANTOIN SUSPENSION ORAL 25 mg/5mL 80 mL · سوسپانسیون خوراکی نیتروفورانتوئین ۲۵ میلیگرم / ۵ میلیلیتر ۸۰ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Macrobid · How SuppliedFDA Nitrofurantoin macro · How SuppliedFDA Nitrofurantoin susp · 3FDA Macrobid · Dosage and AdministrationFDA Nitrofurantoin susp · 2.1FDA Nitrofurantoin macro · Dosage and AdministrationFDA Nitrofurantoin susp · 2.2FDA Macrobid · ContraindicationsFDA Nitrofurantoin susp · 4FDA Nitrofurantoin macro · CONTRAINDICATIONSFDA Nitrofurantoin macro · Precautions/Warnings – Nursing MothersFDA Nitrofurantoin macro · Precautions/Warnings – Pediatric UseFDA Nitrofurantoin macro · Precautions/Warnings – Geriatric UseFDA Nitrofurantoin macro · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-455/Nitrofurantoin
- Clinical review⚠ Unverified