Doz

Nitroglycerin 0.4% ointment (anal fissure)

پماد نیتروگلیسرین ۰٫۴٪ (شقاق مقعد)

⚠ Unverified

❤️ Cardiovascular SystemTopical nitrate

🤰 Pregnancy:Use with caution👶 Children:Safety not established👴 Older adults:Use with caution 🇮🇷 Registered in Iran⛔ 1 contraindications⚠️ 1 interactions 🇺🇸 FDA approved (NDA) NDA021359ATC C05AE01

Market / country: 🇺🇸 USA

Rectiv (US)

🧮 Dose calculator

Anal fissure · Regimen source: FDA Rectiv · 2

⛔ With a covered finger, a 1-inch line as marked on the carton (375 mg ointment = 1.5 mg nitroglycerin) gently into the anal canal; every 12 h for up to 3 weeks. FDA Rectiv · 2

🛡️ Safety & information

Contraindications

  • ⛔ PDE5 inhibitors (sildenafil, tadalafil, vardenafil); severe anaemia; raised intracranial pressure; nitrate hypersensitivity. FDA Rectiv · 4

Important interactions

  • • Sildenafil, tadalafil and vardenafil: severe hypotension — contraindicated. FDA Rectiv · 4

Formulations

  • 0.4% ointment (1 inch = 1.5 mg nitroglycerin) — ointment 🇺🇸 USA FDA Rectiv · 3

👥 Special populations

  • 🤰 PregnancyUse with caution

    Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Rectiv · 8.1

    “Risk Summary There are no data on the use of nitroglycerin ointment intra-anally during pregnancy to determine a drug-associated risk of major birth defects, miscarriage or other adverse maternal or fetal outcomes.”
  • 🤱 BreastfeedingNo data

    The source for this drug has no section for this group.

  • 👶 ChildrenSafety not established

    Label: safety and effectiveness in children have not been established. FDA Rectiv · 8.4

    “The safety and effectiveness of RECTIV in pediatric patients under 18 years of age have not been established.”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Rectiv · 8.5

    “Clinical studies of RECTIV did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.”
  • ⚥ Females & males of reproductive potentialNo data

    The source for this drug has no section for this group.

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