[{"data":1,"prerenderedAt":317},["ShallowReactive",2],{"drug-paroxetine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":12,"synonyms":19,"formulations":25,"regimens":64,"contraindications":166,"warnings":198,"renal":199,"monitoring":200,"interactions":201,"review":202,"examples":205,"atc":223,"iran":225,"links":253,"populations":270,"usApproval":312},"paroxetine",1,{"fa":7,"en":8},"پاروکستین","Paroxetine","nervous-system",{"fa":11,"en":11},"SSRI",[13,16],{"name":14,"market":15},"Paxil","US",{"name":17,"market":18},"Seroxat","GB",[20,21,22,23,7,24],"paxil","seroxat","سروکسات","پاکسیل","پاروکستین ۲۰",[26,40,48,56],{"id":27,"form":28,"route":29,"label":30,"concentration":31,"markets":35,"refs":36},"tab-10","tablet","oral","10 mg tablet",{"amount":32,"unit":33,"perUnit":28,"scored":34},10,"mg",false,[15],[37],{"source":38,"section":39},"fda-paroxetine","3",{"id":41,"form":28,"route":29,"label":42,"concentration":43,"markets":45,"refs":46},"tab-20","20 mg tablet",{"amount":44,"unit":33,"perUnit":28,"scored":34},20,[15],[47],{"source":38,"section":39},{"id":49,"form":28,"route":29,"label":50,"concentration":51,"markets":53,"refs":54},"tab-30","30 mg tablet",{"amount":52,"unit":33,"perUnit":28,"scored":34},30,[15],[55],{"source":38,"section":39},{"id":57,"form":28,"route":29,"label":58,"concentration":59,"markets":61,"refs":62},"tab-40","40 mg tablet",{"amount":60,"unit":33,"perUnit":28,"scored":34},40,[15],[63],{"source":38,"section":39},[65,91,110,129,147],{"id":66,"disease":66,"label":67,"population":70,"type":74,"unit":33,"dose":75,"refs":76,"limits":79,"notes":83},"mdd",{"fa":68,"en":69},"افسردگی اساسی — ۲۰ mg روزانه (حداکثر ۵۰)","Major depression — 20 mg daily (max 50)",{"minAge":71},{"value":72,"unit":73},18,"year","fixed",{"perDose":44,"dosesPerDay":5},[77],{"source":38,"section":78},"2.2, Table 1",{"maxPerDay":80,"refs":81},50,[82],{"source":38,"section":78},[84],{"text":85,"refs":88},{"fa":86,"en":87},"سالمند یا نارسایی شدید کلیه\u002Fکبد: شروع ۱۰ mg، حداکثر ۴۰ mg.","Elderly or severe renal\u002Fhepatic impairment: start 10 mg, max 40 mg.",[89],{"source":38,"section":90},"2.5",{"id":92,"disease":92,"label":93,"population":96,"type":74,"unit":33,"dose":98,"refs":99,"limits":101,"notes":105},"ocd",{"fa":94,"en":95},"OCD — ۲۰ mg روزانه (حداکثر ۶۰)","OCD — 20 mg daily (max 60)",{"minAge":97},{"value":72,"unit":73},{"perDose":44,"dosesPerDay":5},[100],{"source":38,"section":78},{"maxPerDay":102,"refs":103},60,[104],{"source":38,"section":78},[106],{"text":107,"refs":108},{"fa":86,"en":87},[109],{"source":38,"section":90},{"id":111,"disease":112,"label":113,"population":116,"type":74,"unit":33,"dose":118,"refs":119,"limits":121,"notes":124},"panic","panic-disorder",{"fa":114,"en":115},"اختلال پانیک — ۱۰ mg روزانه (حداکثر ۶۰)","Panic disorder — 10 mg daily (max 60)",{"minAge":117},{"value":72,"unit":73},{"perDose":32,"dosesPerDay":5},[120],{"source":38,"section":78},{"maxPerDay":102,"refs":122},[123],{"source":38,"section":78},[125],{"text":126,"refs":127},{"fa":86,"en":87},[128],{"source":38,"section":90},{"id":130,"disease":130,"label":131,"population":134,"type":74,"unit":33,"dose":136,"refs":137,"limits":139,"notes":142},"ptsd",{"fa":132,"en":133},"PTSD — ۲۰ mg روزانه (حداکثر ۵۰)","PTSD — 20 mg daily (max 50)",{"minAge":135},{"value":72,"unit":73},{"perDose":44,"dosesPerDay":5},[138],{"source":38,"section":78},{"maxPerDay":80,"refs":140},[141],{"source":38,"section":78},[143],{"text":144,"refs":145},{"fa":86,"en":87},[146],{"source":38,"section":90},{"id":148,"disease":149,"label":150,"population":153,"type":74,"unit":33,"dose":155,"refs":156,"notes":159},"gad-sad","gad",{"fa":151,"en":152},"اضطراب فراگیر \u002F اضطراب اجتماعی — ۲۰ mg روزانه","GAD \u002F social anxiety — 20 mg daily",{"minAge":154},{"value":72,"unit":73},{"perDose":44,"dosesPerDay":5},[157],{"source":38,"section":158},"2.3",[160],{"text":161,"refs":164},{"fa":162,"en":163},"در پاسخ ناکافی ۱۰ mg افزایش با فاصله حداقل ۱ هفته.","If inadequate, increase by 10 mg at intervals of at least 1 week.",[165],{"source":38,"section":158},[167,176,186],{"id":168,"severity":169,"text":170,"refs":173},"maoi","block",{"fa":171,"en":172},"همراه یا تا 14 روز پس از MAOI (از جمله لینزولید یا متیلن بلو وریدی).","With or within 14 days of an MAOI (including linezolid or IV methylene blue).",[174],{"source":38,"section":175},"4",{"id":177,"severity":169,"rule":178,"text":180,"refs":183},"child",{"maxAge":179},{"value":72,"unit":73},{"fa":181,"en":182},"برای کودکان تأیید نشده.","Not approved for pediatric use.",[184],{"source":38,"section":185},"8.4",{"id":187,"severity":188,"rule":189,"text":192,"refs":195},"suicide","warn",{"maxAge":190},{"value":191,"unit":73},25,{"fa":193,"en":194},"هشدار جعبه‌ای: افزایش افکار و رفتار خودکشی در کودکان، نوجوانان و جوانان.","Boxed warning: increased suicidal thoughts and behaviour in children, adolescents and young adults.",[196],{"source":38,"section":197},"Boxed Warning",[],[],[],[],{"status":203,"reviewer":204,"date":204},"unverified",null,[206,211,214,217,220],{"regimen":66,"formulation":41,"input":207,"expect":210},{"ageYears":208,"weightKg":209},35,70,{"perDose":44},{"regimen":92,"formulation":41,"input":212,"expect":213},{"ageYears":52,"weightKg":209},{"perDose":44},{"regimen":111,"formulation":27,"input":215,"expect":216},{"ageYears":52,"weightKg":209},{"perDose":32},{"regimen":130,"formulation":41,"input":218,"expect":219},{"ageYears":52,"weightKg":209},{"perDose":44},{"regimen":148,"formulation":41,"input":221,"expect":222},{"ageYears":52,"weightKg":209},{"perDose":44},[224],"N06AB05",{"status":226,"forms":227,"refs":248},"registered",[228,232,236,240,244],{"code":229,"en":230,"fa":231},"20409","PAROXETIN 10MG TAB","قرص پاروکستین ۱۰ میلی‌گرم",{"code":233,"en":234,"fa":235},"05932","PAROXETIN 20MG TAB","قرص پاروکستین ۲۰ میلی‌گرم",{"code":237,"en":238,"fa":239},"09975","PAROXETIN 30MG TAB","قرص پاروکستین ۳۰ میلی‌گرم",{"code":241,"en":242,"fa":243},"23027","PAROXETIN 40MG TAB","قرص پاروکستین ۴۰ میلی‌گرم",{"code":245,"en":246,"fa":247},"52184","PAROXETINE (AS MESILATE) TABLET ORAL 20 mg","قرص پاروکستین (معادل مزیلات) ۲۰ میلی‌گرم",[249],{"source":250,"section":251,"url":252},"darooyab-generic","G-604\u002FParoxetine","https:\u002F\u002Fwww.darooyab.ir\u002FG-604\u002FParoxetine",[254,258,262,265,268],{"kind":255,"url":256,"label":257},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=077584","ANDA077584",{"kind":259,"url":260,"label":261},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=598ece4d-0ac4-993b-e063-6294a90a1d34","FDA Paroxetine",{"kind":263,"url":264,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa698032.html",{"kind":266,"url":267,"label":224},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06AB05",{"kind":269,"url":252,"label":8},"darooyab",{"pregnancy":271,"lactation":280,"pediatric":288,"geriatric":296,"reproductive":304},{"level":272,"text":273,"quote":276,"refs":277},"caution",{"fa":274,"en":275},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Based on data from published observational studies, exposure to SSRIs, particularly in the month before delivery, has been associated with a less than 2-fold increase in the risk of postpartum hemorrhage [see Warnings and Precautions ( 5.5 ) and Clinical Considerations].",[278],{"source":38,"section":279},"8.1",{"level":272,"text":281,"quote":284,"refs":285},{"fa":282,"en":283},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Data from the published literature report the presence of paroxetine in human milk (see Data).",[286],{"source":38,"section":287},"8.2",{"level":289,"text":290,"quote":293,"refs":294},"avoid",{"fa":291,"en":292},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies.",[295],{"source":38,"section":197},{"level":272,"text":297,"quote":300,"refs":301},{"fa":298,"en":299},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","SSRIs including paroxetine, have been associated with cases of clinically significant hyponatremia in elderly patients, who may be at greater risk for this adverse reaction [see Warnings and Precautions ( 5.7 )].",[302],{"source":38,"section":303},"8.5",{"level":272,"text":305,"quote":308,"refs":309},{"fa":306,"en":307},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Male Based on findings from clinical studies, paroxetine may affect sperm quality which may impair fertility; it is not known if this effect is reversible [see Nonclinical Toxicology ( 13.1 )].",[310],{"source":38,"section":311},"8.3",{"kind":313,"refs":314,"id":257},"ANDA",[315],{"source":38,"section":316},"SPL approval \u002F marketing category",1792191879365]