[{"data":1,"prerenderedAt":281},["ShallowReactive",2],{"drug-penicillin-g-benzathine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":24,"regimens":52,"contraindications":153,"warnings":172,"renal":173,"monitoring":174,"interactions":175,"review":176,"examples":179,"atc":209,"iran":211,"links":227,"populations":242,"usApproval":276},"penicillin-g-benzathine",1,{"fa":7,"en":8},"پنی‌سیلین بنزاتین","Penicillin G benzathine","anti-infectives",{"fa":11,"en":12},"پنی‌سیلین طولانی‌اثر (عضلانی)","Long-acting penicillin (IM)",[14],{"name":15,"market":16},"Bicillin L-A","US",[18,19,20,21,7,22,23],"bicillin","benzathine penicillin","پنی سیلین ۱۲۰۰","پنی سیلین 6.3.3","پنیسیلین","penicillin 1200",[25,38,45],{"id":26,"form":27,"route":28,"label":29,"concentration":30,"markets":33,"refs":34},"syr-1ml","injection","im","600,000 units \u002F 1 mL prefilled syringe (600,000 units\u002FmL)",{"amount":31,"unit":32,"perVolumeMl":5},600000,"unit",[16],[35],{"source":36,"section":37},"fda-bicillin-la","How Supplied",{"id":39,"form":27,"route":28,"label":40,"concentration":41,"markets":42,"refs":43},"syr-2ml","1,200,000 units \u002F 2 mL prefilled syringe (600,000 units\u002FmL)",{"amount":31,"unit":32,"perVolumeMl":5},[16],[44],{"source":36,"section":37},{"id":46,"form":27,"route":28,"label":47,"concentration":48,"markets":49,"refs":50},"syr-4ml","2,400,000 units \u002F 4 mL prefilled syringe (600,000 units\u002FmL)",{"amount":31,"unit":32,"perVolumeMl":5},[16],[51],{"source":36,"section":37},[53,70,83,102,121,135],{"id":54,"disease":55,"label":56,"population":59,"type":63,"unit":32,"dose":64,"refs":66,"durationDays":69},"strep-adult","streptococcal-pharyngitis",{"fa":57,"en":58},"فارنژیت استرپتوکوکی — بزرگسال: ۱٬۲۰۰٬۰۰۰ واحد تک‌دوز","Strep pharyngitis — adults: 1,200,000 units single dose",{"minAge":60},{"value":61,"unit":62},18,"year","fixed",{"perDose":65,"dosesPerDay":5},1200000,[67],{"source":36,"section":68},"Dosage and Administration",{"min":5,"max":5},{"id":71,"disease":55,"label":72,"population":75,"type":63,"unit":32,"dose":78,"refs":80,"durationDays":82},"strep-small",{"fa":73,"en":74},"فارنژیت استرپتوکوکی — کودک زیر ۲۷ kg (۶۰ پوند): ۳۰۰٬۰۰۰ تا ۶۰۰٬۰۰۰ واحد","Strep pharyngitis — child under 27 kg (60 lb): 300,000–600,000 units",{"maxAge":76,"maxWeightKg":77},{"value":61,"unit":62},27.2,{"perDose":79,"perDoseMax":31,"dosesPerDay":5},300000,[81],{"source":36,"section":68},{"min":5,"max":5},{"id":84,"disease":55,"label":85,"population":88,"type":63,"unit":32,"dose":90,"refs":92,"durationDays":94,"notes":95},"strep-older",{"fa":86,"en":87},"فارنژیت استرپتوکوکی — کودکان بزرگ‌تر: ۹۰۰٬۰۰۰ واحد","Strep pharyngitis — older children: 900,000 units",{"maxAge":89,"minWeightKg":77},{"value":61,"unit":62},{"perDose":91,"dosesPerDay":5},900000,[93],{"source":36,"section":68},{"min":5,"max":5},[96],{"text":97,"refs":100},{"fa":98,"en":99},"برچسب «کودکان بزرگ‌تر» را بدون مرز دقیق آورده؛ Doz آن را بالای ۶۰ پوند (۲۷ kg) گذاشته است.","The label says \"older pediatric patients\" without an exact cut-off; Doz uses above 60 lb (27 kg).",[101],{"source":36,"section":68},{"id":103,"disease":103,"label":104,"population":107,"type":63,"unit":32,"dose":109,"refs":111,"durationDays":113,"notes":114},"syphilis",{"fa":105,"en":106},"سیفلیس اولیه، ثانویه و نهفته: ۲٬۴۰۰٬۰۰۰ واحد تک‌دوز","Primary, secondary and latent syphilis: 2,400,000 units once",{"minAge":108},{"value":61,"unit":62},{"perDose":110,"dosesPerDay":5},2400000,[112],{"source":36,"section":68},{"min":5,"max":5},[115],{"text":116,"refs":119},{"fa":117,"en":118},"سیفلیس دیررس (ثالثیه و نوروسیفلیس): ۲٬۴۰۰٬۰۰۰ واحد هر ۷ روز، ۳ دوز.","Late (tertiary and neurosyphilis): 2,400,000 units every 7 days for three doses.",[120],{"source":36,"section":68},{"id":122,"disease":103,"label":123,"population":126,"type":129,"unit":32,"dose":130,"refs":132,"durationDays":134},"congenital",{"fa":124,"en":125},"سیفلیس مادرزادی — زیر ۲ سال: ۵۰٬۰۰۰ واحد\u002Fkg","Congenital syphilis — under 2 y: 50,000 units\u002Fkg",{"maxAge":127},{"value":128,"unit":62},2,"weightBased",{"perKgPerDay":131,"dividedDoses":5},50000,[133],{"source":36,"section":68},{"min":5,"max":5},{"id":136,"disease":137,"label":138,"population":141,"type":63,"unit":32,"dose":142,"refs":143,"durationDays":145,"notes":146},"rf-prophylaxis","rheumatic-fever-prophylaxis",{"fa":139,"en":140},"پیشگیری از تب روماتیسمی: ۱٬۲۰۰٬۰۰۰ واحد ماهی یک بار","Rheumatic fever prophylaxis: 1,200,000 units once a month",{},{"perDose":65,"dosesPerDay":5},[144],{"source":36,"section":68},{"min":5,"max":5},[147],{"text":148,"refs":151},{"fa":149,"en":150},"هر ماه تکرار شود؛ یا ۶۰۰٬۰۰۰ واحد هر ۲ هفته. (مقدار «روزانه» نمایش‌داده‌شده یعنی یک تزریق.)","Repeat every month; or 600,000 units every 2 weeks. (The \"per day\" figure shown is one injection.)",[152],{"source":36,"section":68},[154,163],{"id":155,"severity":156,"text":157,"refs":160},"ci","block",{"fa":158,"en":159},"سابقه حساسیت به هر پنی‌سیلین.","History of hypersensitivity to any penicillin.",[161],{"source":36,"section":162},"Contraindications",{"id":164,"severity":165,"text":166,"refs":169},"no-iv","warn",{"fa":167,"en":168},"هشدار جعبه‌ای: فقط عضلانی؛ تزریق وریدی با ایست قلبی-تنفسی و مرگ همراه بوده است.","Boxed warning: IM only; IV injection has caused cardiorespiratory arrest and death.",[170],{"source":36,"section":171},"Boxed Warning",[],[],[],[],{"status":177,"reviewer":178,"date":178},"unverified",null,[180,185,191,197,201,206],{"regimen":54,"formulation":39,"input":181,"expect":184},{"ageYears":182,"weightKg":183},30,70,{"perDose":65,"mlPerDose":128},{"regimen":71,"formulation":26,"input":186,"expect":189},{"ageYears":187,"weightKg":188},5,20,{"mlPerDose":190,"upperPerDose":31},0.5,{"regimen":84,"formulation":26,"input":192,"expect":195},{"ageYears":193,"weightKg":194},12,40,{"mlPerDose":196},1.5,{"regimen":103,"formulation":46,"input":198,"expect":199},{"ageYears":182,"weightKg":183},{"mlPerDose":200},4,{"regimen":122,"formulation":26,"input":202,"expect":204},{"ageYears":203,"weightKg":200},0.1,{"perDose":205},200000,{"regimen":136,"formulation":39,"input":207,"expect":208},{"ageYears":193,"weightKg":194},{"mlPerDose":128},[210],"J01CE08",{"status":212,"forms":213,"refs":222},"registered",[214,218],{"code":215,"en":216,"fa":217},"01628","PENICILLIN G BENZATHINE (PEN L A) 600,000 U VIAL","قلم تزریقی پنی‌سیلین گرم بنزاتین (لیتر A) ۶۰۰۰۰۰ واحد",{"code":219,"en":220,"fa":221},"00958","PENICILLIN G BENZATHINE (PEN LA) 1,200,000 U VIAL","قلم تزریقی پنی‌سیلین گرم بنزاتین (طولانی‌اثر) ۱۲۰۰۰۰۰ واحد",[223],{"source":224,"section":225,"url":226},"darooyab-generic","G-296\u002FBenzathine-Penicillin","https:\u002F\u002Fwww.darooyab.ir\u002FG-296\u002FBenzathine-Penicillin",[228,232,236,239],{"kind":229,"url":230,"label":231},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=050141","NDA050141",{"kind":233,"url":234,"label":235},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=012d46f1-d0a0-4676-a879-cd320297ab16","FDA Bicillin L-A",{"kind":237,"url":238,"label":210},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01CE08",{"kind":240,"url":226,"label":241},"darooyab","Benzathine-Penicillin",{"pregnancy":243,"lactation":252,"pediatric":260,"geriatric":268},{"level":244,"text":245,"quote":248,"refs":249},"caution",{"fa":246,"en":247},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.",[250],{"source":36,"section":251},"Pregnancy",{"level":244,"text":253,"quote":256,"refs":257},{"fa":254,"en":255},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution should be exercised when penicillin G benzathine is administered to a nursing woman.",[258],{"source":36,"section":259},"Nursing Mothers",{"level":244,"text":261,"quote":264,"refs":265},{"fa":262,"en":263},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","(See INDICATIONS AND USAGE and DOSAGE AND ADMINISTRATION sections.)",[266],{"source":36,"section":267},"Pediatric Use",{"level":244,"text":269,"quote":272,"refs":273},{"fa":270,"en":271},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[274],{"source":36,"section":275},"Geriatric Use",{"kind":277,"refs":278,"id":231},"NDA",[279],{"source":36,"section":280},"SPL approval \u002F marketing category",1792191874253]