[{"data":1,"prerenderedAt":172},["ShallowReactive",2],{"drug-permethrin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":61,"warnings":81,"renal":82,"monitoring":83,"interactions":84,"review":85,"examples":88,"atc":89,"iran":91,"links":115,"populations":133,"usApproval":167},"permethrin",1,{"fa":7,"en":8},"پرمترین","Permethrin","antiparasitic",{"fa":11,"en":12},"ضدانگل خارجی (پیرتروئید)","Topical scabicide (pyrethroid)",[14],{"name":15,"market":16},"Elimite","US",[7,18,19],"کرم گال","elimite",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"cream-5","cream","topical","Permethrin 5% cream",{"amount":27,"unit":28,"perUnit":29},5,"g","tube",[16],[32],{"source":33,"section":34},"fda-permethrin-cream","Indications and Usage",[36],{"id":37,"disease":37,"label":38,"population":41,"type":45,"unit":46,"dose":47,"refs":51,"notes":54},"scabies",{"fa":39,"en":40},"گال — یک‌بار مالیدن از سر تا کف پا","Scabies — single application head to soles",{"minAge":42},{"value":43,"unit":44},2,"month","notCalculated","mg",{"reason":48},{"fa":49,"en":50},"دوز وزنی ندارد: کرم را کامل از سر تا کف پا ماساژ دهید (بزرگسال معمولاً ۳۰ گرم)، پس از ۸ تا ۱۴ ساعت بشویید. در شیرخوار پوست سر، شقیقه و پیشانی هم درمان شود. یک بار معمولاً کافی است؛ اگر پس از ۱۴ روز مایت زنده دیده شد، تکرار.","Not weight-dosed: massage thoroughly from head to soles (about 30 g for an average adult), wash off after 8–14 h. In infants also treat scalp, temple and forehead. One application is generally curative; retreat only if living mites after 14 days.",[52],{"source":33,"section":53},"Dosage and Administration",[55],{"text":56,"refs":59},{"fa":57,"en":58},"خارش ممکن است پس از درمان ادامه یابد و به‌تنهایی دلیل تکرار نیست.","Itching may persist after treatment and is not by itself a reason to retreat.",[60],{"source":33,"section":53},[62,71],{"id":63,"severity":64,"text":65,"refs":68},"hypersensitivity","block",{"fa":66,"en":67},"حساسیت به پرمترین، پیرتروئیدها یا پیرترین.","Hypersensitivity to permethrin, synthetic pyrethroids or pyrethrins.",[69],{"source":33,"section":70},"Contraindications",{"id":72,"severity":64,"rule":73,"text":75,"refs":78},"under-2-months",{"maxAge":74},{"value":43,"unit":44},{"fa":76,"en":77},"بی‌خطری زیر ۲ ماه ثابت نشده است.","Not established under 2 months.",[79],{"source":33,"section":80},"Pediatric Use",[],[],[],[],{"status":86,"reviewer":87,"date":87},"unverified",null,[],[90],"P03AC04",{"status":92,"forms":93,"refs":110},"registered",[94,98,102,106],{"code":95,"en":96,"fa":97},"01631","PERMETHRIN 1% 100ML SHAMPOO","شامپو پرمترین ۱ درصد ۱۰۰ میلی‌لیتر",{"code":99,"en":100,"fa":101},"01779","PERMETHRIN 1% 60ML SHAMPOO","شامپو پرمترین ۱ درصد ۶۰ میلی‌لیتر",{"code":103,"en":104,"fa":105},"01632","PERMETHRIN 1% W\u002FW CREAM RINSE","کرم پرمترین ۱ درصد W \u002F W رینس",{"code":107,"en":108,"fa":109},"02449","PERMETRIN 5% TOP CREAM","کرم پرمترین ۵ درصد",[111],{"source":112,"section":113,"url":114},"darooyab-generic","G-3151\u002FPermethrin","https:\u002F\u002Fwww.darooyab.ir\u002FG-3151\u002FPermethrin",[116,120,124,128,131],{"kind":117,"url":118,"label":119},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=209732","ANDA209732",{"kind":121,"url":122,"label":123},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=31de941a-d5b9-8de5-6695-daca8b57d010","FDA Permethrin 5%",{"kind":125,"url":126,"label":127},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa698037.html","Permethrin Topical",{"kind":129,"url":130,"label":90},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=P03AC04",{"kind":132,"url":114,"label":8},"darooyab",{"pregnancy":134,"lactation":143,"pediatric":151,"geriatric":159},{"level":135,"text":136,"quote":139,"refs":140},"caution",{"fa":137,"en":138},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratorgenic Effects: Pregnancy Category B Reproduction studies have been performed in mice, rats, and rabbits (200 to 400 mg\u002Fkg\u002Fday orally) and have revealed no evidence of impaired fertility or harm to the fetus due to permethrin.",[141],{"source":33,"section":142},"Pregnancy:",{"level":135,"text":144,"quote":147,"refs":148},{"fa":145,"en":146},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk and because of the evidence for tumorigenic potential of permethrin in animal studies, consideration should be given to discontinuing nursing temporarily or withholding the drug while the mother is nursing.",[149],{"source":33,"section":150},"Nursing Mothers",{"level":152,"text":153,"quote":156,"refs":157},"not-established",{"fa":154,"en":155},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in infants less than two months of age have not been established.",[158],{"source":33,"section":80},{"level":135,"text":160,"quote":163,"refs":164},{"fa":161,"en":162},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","However, since topical permethrin is metabolized in the liver and excreted in the urine as inactive metabolites, there does not appear to be an increased risk of toxic reactions in patients with impaired renal function when used as labeled.",[165],{"source":33,"section":166},"Geriatric Use",{"kind":168,"refs":169,"id":119},"ANDA",[170],{"source":33,"section":171},"SPL approval \u002F marketing category",1792440740649]