[{"data":1,"prerenderedAt":240},["ShallowReactive",2],{"drug-progesterone-vaginal":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":20,"formulations":25,"regimens":48,"contraindications":91,"warnings":101,"renal":102,"monitoring":103,"interactions":104,"review":105,"examples":108,"atc":118,"iran":120,"links":179,"populations":200,"usApproval":235},"progesterone-vaginal",1,{"fa":7,"en":8},"پروژسترون واژینال","Progesterone (vaginal)","genitourinary-sex-hormones",{"fa":11,"en":12},"پروژستین","Progestin",[14,17],{"name":15,"market":16},"Crinone","US",{"name":18,"market":19},"Cyclogest","GB",[21,22,23,24,7],"crinone","cyclogest","سیکلوژست","شیاف پروژسترون",[26,40],{"id":27,"form":28,"route":29,"label":30,"concentration":31,"markets":35,"refs":36},"gel-90","gel","vaginal","Crinone 8% (90 mg) applicator",{"amount":32,"unit":33,"perUnit":34},90,"mg","application",[16],[37],{"source":38,"section":39},"fda-crinone","How Supplied",{"id":41,"form":28,"route":29,"label":42,"concentration":43,"markets":45,"refs":46},"gel-45","Crinone 4% (45 mg) applicator",{"amount":44,"unit":33,"perUnit":34},45,[16],[47],{"source":38,"section":39},[49,72],{"id":50,"disease":51,"label":52,"population":55,"type":59,"unit":33,"dose":60,"refs":61,"allowedFormulations":64,"notes":65},"art","female-infertility",{"fa":53,"en":54},"حمایت لوتئال در ART — کرینون ۸٪ (۹۰ mg) یک بار در روز واژینال","ART luteal support — Crinone 8% (90 mg) vaginally once daily",{"minAge":56},{"value":57,"unit":58},18,"year","fixed",{"perDose":32,"dosesPerDay":5},[62],{"source":38,"section":63},"Dosage and Administration",[27],[66],{"text":67,"refs":70},{"fa":68,"en":69},"نارسایی کامل\u002Fنسبی تخمدان: ۹۰ mg دو بار. در صورت بارداری تا ۱۰ تا ۱۲ هفته ادامه.","Partial or complete ovarian failure: 90 mg twice daily. If pregnant, continue to 10–12 weeks.",[71],{"source":38,"section":63},{"id":73,"disease":74,"label":75,"population":78,"type":59,"unit":33,"dose":80,"refs":81,"allowedFormulations":83,"notes":84},"amen","secondary-amenorrhea",{"fa":76,"en":77},"آمنوره ثانویه — کرینون ۴٪ (۴۵ mg) یک روز در میان، ۶ دوز","Secondary amenorrhoea — Crinone 4% (45 mg) every other day, 6 doses",{"minAge":79},{"value":57,"unit":58},{"perDose":44,"dosesPerDay":5},[82],{"source":38,"section":63},[41],[85],{"text":86,"refs":89},{"fa":87,"en":88},"اگر پاسخ نداد، ۸٪ یک روز در میان تا ۶ دوز.","If no response, 8% every other day up to 6 doses.",[90],{"source":38,"section":63},[92],{"id":93,"severity":94,"text":95,"refs":98},"ci","block",{"fa":96,"en":97},"خونریزی واژینال تشخیص‌داده‌نشده؛ بیماری کبد؛ سرطان پستان یا دستگاه تناسلی؛ ترومبوآمبولی؛ سقط فراموش‌شده.","Undiagnosed vaginal bleeding; liver disease; breast or genital cancer; thromboembolism; missed abortion.",[99],{"source":38,"section":100},"Contraindications",[],[],[],[],{"status":106,"reviewer":107,"date":107},"unverified",null,[109,114],{"regimen":50,"formulation":27,"input":110,"expect":113},{"ageYears":111,"weightKg":112},32,60,{"perDose":32},{"regimen":73,"formulation":41,"input":115,"expect":117},{"ageYears":116,"weightKg":112},28,{"perDose":44},[119],"G03DA04",{"status":121,"forms":122,"refs":174},"registered",[123,127,131,135,139,143,147,151,154,158,162,166,170],{"code":124,"en":125,"fa":126},"18897","PROGESTERONE 100MG  CAP.","کپسول پروژسترون ۱۰۰ میلی‌گرم .",{"code":128,"en":129,"fa":130},"19093","PROGESTERONE 100MG VAG TAB","قرص واژینال پروژسترون ۱۰۰ میلی‌گرم",{"code":132,"en":133,"fa":134},"18898","PROGESTERONE 200MG  CAP.","کپسول پروژسترون ۲۰۰ میلی‌گرم .",{"code":136,"en":137,"fa":138},"02534","PROGESTERONE 200MG PESSARY","پروژسترون ۲۰۰ میلی‌گرم پسساری",{"code":140,"en":141,"fa":142},"02355","PROGESTERONE 200MG VAG SUPP","شیاف پروژسترون ۲۰۰ میلی‌گرم",{"code":144,"en":145,"fa":146},"01057","PROGESTERONE 25MG\u002F1ML AMP","آمپول پروژسترون ۲۵ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":148,"en":149,"fa":150},"02082","PROGESTERONE 400MG SUPP","شیاف پروژسترون ۴۰۰ میلی‌گرم",{"code":152,"en":153,"fa":150},"01059","PROGESTERONE 400MG VAG SUPP",{"code":155,"en":156,"fa":157},"01058","PROGESTERONE 50MG\u002F1ML AMP","آمپول پروژسترون ۵۰ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":159,"en":160,"fa":161},"14624","PROGESTERONE 80G GEL","ژل پروژسترون ۸۰ گرم",{"code":163,"en":164,"fa":165},"01056","PROGESTERONE_BULK","ماده اولیه پروژسترون",{"code":167,"en":168,"fa":169},"52265","PROGESTERONE GEL VAGINAL 8 % 22.5 g","ژل پروژسترون ۸ درصد ۲۲٫۵ گرم",{"code":171,"en":172,"fa":173},"53109","PROGESTERONE INJECTION PARENTERAL 25 mg\u002F1mL 2 mL","فرآورده تزریقی پروژسترون ۲۵ میلی‌گرم \u002F ۱ میلی‌لیتر ۲ میلی‌لیتر",[175],{"source":176,"section":177,"url":178},"darooyab-generic","G-3304\u002FProgesterone","https:\u002F\u002Fwww.darooyab.ir\u002FG-3304\u002FProgesterone",[180,184,188,192,195,198],{"kind":181,"url":182,"label":183},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=020701","NDA020701",{"kind":185,"url":186,"label":187},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=75e97aa1-daa4-45f9-b2e2-1a371302914e","FDA Crinone",{"kind":189,"url":190,"label":191},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa604017.html","Progesterone",{"kind":189,"url":193,"label":194},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa623013.html","Progesterone Vaginal",{"kind":196,"url":197,"label":119},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G03DA04",{"kind":199,"url":178,"label":191},"darooyab",{"pregnancy":201,"lactation":210,"pediatric":218,"geriatric":227},{"level":202,"text":203,"quote":206,"refs":207},"caution",{"fa":204,"en":205},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","[See CLINICAL STUDIES, Assisted Reproductive Technology ] Crinone 8% has been used to support embryo implantation and maintain pregnancies through its use as part of ART treatment regimens in two clinical studies (studies COL1620-007US and COL1620-F01).",[208],{"source":38,"section":209},"Pregnancy",{"level":202,"text":211,"quote":214,"refs":215},{"fa":212,"en":213},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Detectable amounts of progestins have been identified in the milk of mothers receiving them.",[216],{"source":38,"section":217},"Nursing Mothers",{"level":219,"text":220,"quote":223,"refs":224},"not-established",{"fa":221,"en":222},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[225],{"source":38,"section":226},"Pediatric Use",{"level":202,"text":228,"quote":231,"refs":232},{"fa":229,"en":230},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","The safety and effectiveness in geriatric patients (over age 65) have not been established.",[233],{"source":38,"section":234},"Geriatric Use",{"kind":236,"refs":237,"id":183},"NDA",[238],{"source":38,"section":239},"SPL approval \u002F marketing category",1792440728730]