[{"data":1,"prerenderedAt":176},["ShallowReactive",2],{"drug-propylthiouracil":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":81,"warnings":91,"renal":99,"monitoring":100,"interactions":101,"review":102,"examples":105,"atc":112,"iran":114,"links":126,"populations":144,"usApproval":171},"propylthiouracil",1,{"fa":7,"en":8},"پروپیل‌تیواوراسیل","Propylthiouracil (PTU)","systemic-hormones",{"fa":11,"en":12},"ضدتیروئید","Antithyroid",[14],{"name":15,"market":16},"PTU","US",[15,18,19],"پی تی یو","پروپیل تیواوراسیل",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-50","tablet","oral","50 mg tablet (scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},50,"mg",true,[16],[32],{"source":33,"section":34},"fda-ptu","How Supplied",[36,64],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":50,"notes":53},"adult","hyperthyroidism",{"fa":40,"en":41},"پرکاری تیروئید — بزرگسال: ۳۰۰ mg\u002Fday در ۳ نوبت","Hyperthyroidism — adults: 300 mg\u002Fday in 3 doses",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":48,"dosesPerDay":49},100,3,[51],{"source":33,"section":52},"Dosage and Administration, Adults",[54],{"text":55,"refs":58},{"fa":56,"en":57},"هر ۸ ساعت. شدید یا گواتر بزرگ: ۴۰۰ mg\u002Fday (گاهی ۶۰۰ تا ۹۰۰). نگهدارنده ۱۰۰ تا ۱۵۰ mg\u002Fday. ممکن است در سه‌ماهه اول بارداری ارجح باشد.","Every 8 hours. Severe or large goitre: 400 mg\u002Fday (occasionally 600–900). Maintenance 100–150 mg\u002Fday. May be preferred in the first trimester of pregnancy.",[59,60,62],{"source":33,"section":52},{"source":33,"section":61},"Dosage and Administration",{"source":33,"section":63},"Indications and Usage",{"id":65,"disease":38,"label":66,"population":69,"type":71,"unit":28,"dose":72,"refs":76},"peds",{"fa":67,"en":68},"کودکان","Children",{"maxAge":70},{"value":44,"unit":45},"notCalculated",{"reason":73},{"fa":74,"en":75},"به‌علت آسیب شدید کبدی در کودکان توصیه نمی‌شود، مگر وقتی متی‌مازول تحمل نشود و جراحی یا ید رادیواکتیو مناسب نباشد.","Not recommended in children because of severe liver injury, except when methimazole is not tolerated and surgery or radioiodine are unsuitable.",[77,79],{"source":33,"section":78},"Dosage and Administration, Pediatric Patients",{"source":33,"section":80},"Pediatric Use",[82],{"id":83,"severity":84,"text":85,"refs":88},"ci","block",{"fa":86,"en":87},"حساسیت به دارو.","Hypersensitivity to the drug.",[89],{"source":33,"section":90},"Contraindications",[92],{"text":93,"refs":96},{"fa":94,"en":95},"سمیت کبدی: نارسایی کبد، پیوند یا مرگ در بزرگسالان و کودکان گزارش شده است.","Liver toxicity: liver failure, transplantation or death reported in adults and children.",[97],{"source":33,"section":98},"Warnings, Liver Toxicity",[],[],[],{"status":103,"reviewer":104,"date":104},"unverified",null,[106],{"regimen":37,"formulation":22,"input":107,"expect":110},{"ageYears":108,"weightKg":109},40,65,{"perDose":48,"tabletsPerDoseRounded":111},2,[113],"H03BA02",{"status":115,"forms":116,"refs":121},"registered",[117],{"code":118,"en":119,"fa":120},"01072","PROPYLTHIOURACIL 50MG TAB","قرص پروپیلتیووراسیل ۵۰ میلی‌گرم",[122],{"source":123,"section":124,"url":125},"darooyab-generic","G-3417\u002FPropylthiouracil","https:\u002F\u002Fwww.darooyab.ir\u002FG-3417\u002FPropylthiouracil",[127,131,135,139,142],{"kind":128,"url":129,"label":130},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=006188","NDA006188",{"kind":132,"url":133,"label":134},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=b0c23a2c-b250-4c0d-9b2a-c1483faa2ca0","FDA Propylthiouracil",{"kind":136,"url":137,"label":138},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682465.html","Propylthiouracil",{"kind":140,"url":141,"label":113},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=H03BA02",{"kind":143,"url":125,"label":138},"darooyab",{"pregnancy":145,"lactation":154,"pediatric":163},{"level":146,"text":147,"quote":150,"refs":151},"avoid",{"fa":148,"en":149},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Pregnancy Category D.",[152],{"source":33,"section":153},"Pregnancy",{"level":155,"text":156,"quote":159,"refs":160},"caution",{"fa":157,"en":158},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Propylthiouracil is present in breast milk to a small extent and therefore likely results in clinically insignificant doses to the nursing infant.",[161],{"source":33,"section":162},"Nursing Mothers",{"level":146,"text":164,"quote":167,"refs":168},{"fa":165,"en":166},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","These reports of hepatic reactions include cases requiring liver transplantation in adult and pediatric patients.",[169],{"source":33,"section":170},"Boxed Warning",{"kind":172,"refs":173,"id":130},"NDA",[174],{"source":33,"section":175},"SPL approval \u002F marketing category",1792191871997]