[{"data":1,"prerenderedAt":238},["ShallowReactive",2],{"drug-ropinirole":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":58,"contraindications":111,"warnings":131,"renal":132,"monitoring":133,"interactions":134,"review":135,"examples":138,"atc":148,"iran":150,"links":182,"populations":199,"usApproval":233},"ropinirole",1,{"fa":7,"en":8},"روپینیرول","Ropinirole","nervous-system",{"fa":11,"en":12},"آگونیست دوپامین","Dopamine agonist",[14],{"name":15,"market":16},"Requip","US",[18,19,7],"requip","ریکوئیپ",[21,35,43,50],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-0-25","tablet","oral","0.25 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},0.25,"mg",false,[16],[32],{"source":33,"section":34},"fda-ropinirole","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-0-5","0.5 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},0.5,[16],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":47,"refs":48},"tab-1","1 mg tablet",{"amount":5,"unit":28,"perUnit":23,"scored":29},[16],[49],{"source":33,"section":34},{"id":51,"form":23,"route":24,"label":52,"concentration":53,"markets":55,"refs":56},"tab-2","2 mg tablet",{"amount":54,"unit":28,"perUnit":23,"scored":29},2,[16],[57],{"source":33,"section":34},[59,86],{"id":60,"disease":61,"label":62,"population":65,"type":69,"unit":28,"dose":70,"refs":76,"notes":79},"pd","parkinsons",{"fa":63,"en":64},"پارکینسون — شروع ۰٫۲۵ mg سه بار در روز","Parkinson’s disease — start 0.25 mg three times daily",{"minAge":66},{"value":67,"unit":68},18,"year","titration",{"dividedDoses":71,"titration":72},3,{"start":73,"increment":73,"incrementEveryDays":74,"max":75},0.75,7,24,[77],{"source":33,"section":78},"2.2, Table 1",[80],{"text":81,"refs":84},{"fa":82,"en":83},"هفته ۱ تا ۴: ۰٫۲۵، ۰٫۵، ۰٫۷۵، ۱ mg سه بار؛ سپس هفتگی تا ۹ و بعد تا حداکثر ۲۴ mg\u002Fday. قطع تدریجی طی ۷ روز.","Weeks 1–4: 0.25, 0.5, 0.75, 1 mg three times daily; then weekly up to 9 and later max 24 mg\u002Fday. Taper over 7 days.",[85],{"source":33,"section":78},{"id":87,"disease":88,"label":89,"population":92,"type":94,"unit":28,"dose":95,"refs":96,"limits":99,"notes":104},"rls","restless-legs",{"fa":90,"en":91},"پای بی‌قرار — ۰٫۲۵ mg ۱ تا ۳ ساعت قبل از خواب","Restless legs — 0.25 mg 1–3 h before bedtime",{"minAge":93},{"value":67,"unit":68},"fixed",{"perDose":27,"dosesPerDay":5},[97],{"source":33,"section":98},"2.3, Table 2",{"maxPerDay":100,"refs":101},4,[102],{"source":33,"section":103},"2.3",[105],{"text":106,"refs":109},{"fa":107,"en":108},"روز ۱ و ۲: ۰٫۲۵؛ روز ۳ تا ۷: ۰٫۵؛ سپس هفتگی ۱، ۱٫۵، ۲، ۲٫۵، ۳ و ۴ mg؛ حداکثر ۴ mg.","Days 1–2: 0.25; days 3–7: 0.5; then weekly 1, 1.5, 2, 2.5, 3 and 4 mg; max 4 mg.",[110],{"source":33,"section":98},[112,121],{"id":113,"severity":114,"text":115,"refs":118},"ci","block",{"fa":116,"en":117},"حساسیت به روپینیرول.","Hypersensitivity to ropinirole.",[119],{"source":33,"section":120},"4",{"id":122,"severity":114,"rule":123,"text":125,"refs":128},"child",{"maxAge":124},{"value":67,"unit":68},{"fa":126,"en":127},"در کودکان ثابت نشده.","Not established in children.",[129],{"source":33,"section":130},"8.4",[],[],[],[],{"status":136,"reviewer":137,"date":137},"unverified",null,[139,144],{"regimen":60,"formulation":22,"input":140,"expect":143},{"ageYears":141,"weightKg":142},65,70,{"perDose":27},{"regimen":87,"formulation":22,"input":145,"expect":147},{"ageYears":146,"weightKg":142},50,{"perDose":27},[149],"N04BC04",{"status":151,"forms":152,"refs":177},"registered",[153,157,161,165,169,173],{"code":154,"en":155,"fa":156},"02001","ROPINIROLE 0.25MG TAB","قرص روپینیرول ۰٫۲۵ میلی‌گرم",{"code":158,"en":159,"fa":160},"09141","ROPINIROLE 0.5MG TAB","قرص روپینیرول ۰٫۵ میلی‌گرم",{"code":162,"en":163,"fa":164},"02002","ROPINIROLE 1MG TAB","قرص روپینیرول ۱ میلی‌گرم",{"code":166,"en":167,"fa":168},"06590","ROPINIROLE 2MG TAB","قرص روپینیرول ۲ میلی‌گرم",{"code":170,"en":171,"fa":172},"02003","ROPINIROLE 5MG TAB","قرص روپینیرول ۵ میلی‌گرم",{"code":174,"en":175,"fa":176},"16836","ROPINIROLE 8MG TAB","قرص روپینیرول ۸ میلی‌گرم",[178],{"source":179,"section":180,"url":181},"darooyab-generic","G-2498\u002FRopinirole","https:\u002F\u002Fwww.darooyab.ir\u002FG-2498\u002FRopinirole",[183,187,191,194,197],{"kind":184,"url":185,"label":186},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=090429","ANDA090429",{"kind":188,"url":189,"label":190},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=6d1a0f9f-5fa0-43fa-83b9-0d18a129fd0c","FDA Ropinirole",{"kind":192,"url":193,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa698013.html",{"kind":195,"url":196,"label":149},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N04BC04",{"kind":198,"url":181,"label":8},"darooyab",{"pregnancy":200,"lactation":209,"pediatric":217,"geriatric":225},{"level":201,"text":202,"quote":205,"refs":206},"caution",{"fa":203,"en":204},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate data on the developmental risk associated with the use of ropinirole tablets in pregnant women.",[207],{"source":33,"section":208},"8.1",{"level":201,"text":210,"quote":213,"refs":214},{"fa":211,"en":212},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of ropinirole in human milk, the effects of ropinirole on the breastfed infant, or the effects of ropinirole on milk production.",[215],{"source":33,"section":216},"8.2",{"level":218,"text":219,"quote":222,"refs":223},"not-established",{"fa":220,"en":221},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[224],{"source":33,"section":130},{"level":201,"text":226,"quote":229,"refs":230},{"fa":227,"en":228},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Pharmacokinetic trials conducted in patients demonstrated that oral clearance of ropinirole is reduced by 15% in patients older than 65 years compared with younger patients [see Clinical Pharmacology (12.3)] .",[231],{"source":33,"section":232},"8.5",{"kind":234,"refs":235,"id":186},"ANDA",[236],{"source":33,"section":237},"SPL approval \u002F marketing category",1792191878685]