[{"data":1,"prerenderedAt":210},["ShallowReactive",2],{"drug-sildenafil":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":51,"contraindications":82,"warnings":102,"renal":103,"monitoring":104,"interactions":105,"review":106,"examples":109,"atc":114,"iran":116,"links":156,"populations":173,"usApproval":205},"sildenafil",1,{"fa":7,"en":8},"سیلدنافیل","Sildenafil","genitourinary-sex-hormones",{"fa":11,"en":12},"مهارکننده PDE5","PDE5 inhibitor",[14],{"name":15,"market":16},"Viagra","US",[18,19,7],"viagra","ویاگرا",[21,35,43],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-25","tablet","oral","25 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},25,"mg",false,[16],[32],{"source":33,"section":34},"fda-sildenafil","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-50","50 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},50,[16],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":48,"refs":49},"tab-100","100 mg tablet",{"amount":47,"unit":28,"perUnit":23,"scored":29},100,[16],[50],{"source":33,"section":34},[52],{"id":53,"disease":54,"label":55,"population":58,"type":62,"unit":28,"dose":63,"refs":64,"limits":67,"notes":70},"ed","erectile-dysfunction",{"fa":56,"en":57},"اختلال نعوظ — ۵۰ mg حدود ۱ ساعت قبل در صورت نیاز","ED — 50 mg about 1 h before, as needed",{"minAge":59},{"value":60,"unit":61},18,"year","fixed",{"perDose":39,"dosesPerDay":5},[65],{"source":33,"section":66},"2.1",{"maxPerDay":47,"refs":68},[69],{"source":33,"section":66},[71],{"text":72,"refs":75},{"fa":73,"en":74},"۲۵ تا ۱۰۰ mg؛ حداکثر یک بار در روز؛ ۳۰ دقیقه تا ۴ ساعت قبل. بالای ۶۵ سال، نارسایی کبد یا CrCl کمتر از ۳۰: شروع ۲۵ mg. با ریتوناویر حداکثر ۲۵ mg در ۴۸ ساعت.","25–100 mg; at most once daily; 30 min to 4 h before. Over 65, hepatic impairment or CrCl \u003C30: start 25 mg. With ritonavir max 25 mg per 48 h.",[76,78,80],{"source":33,"section":77},"2",{"source":33,"section":79},"2.5",{"source":33,"section":81},"2.4",[83,92],{"id":84,"severity":85,"text":86,"refs":89},"nitrates","block",{"fa":87,"en":88},"همراه هر نوع نیترات (نیتروگلیسیرین، ایزوسورباید) یا محرک‌های گوانیلات سیکلاز (ریوسیگوات): افت شدید فشار.","With any nitrate (nitroglycerin, isosorbide) or guanylate-cyclase stimulators (riociguat): severe hypotension.",[90],{"source":33,"section":91},"4",{"id":93,"severity":85,"rule":94,"text":96,"refs":99},"child",{"maxAge":95},{"value":60,"unit":61},{"fa":97,"en":98},"برای کودکان نیست.","Not indicated in children.",[100],{"source":33,"section":101},"8.4",[],[],[],[],{"status":107,"reviewer":108,"date":108},"unverified",null,[110],{"regimen":53,"formulation":36,"input":111,"expect":113},{"ageYears":39,"weightKg":112},80,{"perDose":39},[115],"G04BE03",{"status":117,"forms":118,"refs":151},"registered",[119,123,127,131,135,139,143,147],{"code":120,"en":121,"fa":122},"01780","SILDENAFIL CITRATE 100MG TAB","قرص سیلدنافیل سیترات ۱۰۰ میلی‌گرم",{"code":124,"en":125,"fa":126},"02098","SILDENAFIL CITRATE 25MG TAB","قرص سیلدنافیل سیترات ۲۵ میلی‌گرم",{"code":128,"en":129,"fa":130},"01781","SILDENAFIL CITRATE 50MG TAB","قرص سیلدنافیل سیترات ۵۰ میلی‌گرم",{"code":132,"en":133,"fa":134},"51942","SILDENAFIL 1 % 15 GRAM TOPICAL GEL","ژل موضعی سیلدنافیل ۱ درصد ۱۵ گرم",{"code":136,"en":137,"fa":138},"51120","SILDENAFIL 1% 30 GRAM TOP GEL","ژل موضعی سیلدنافیل ۱ درصد ۳۰ گرم",{"code":140,"en":141,"fa":142},"52667","SILDENAFIL 1 % 20 GRAM TOPICAL GEL","ژل موضعی سیلدنافیل ۱ درصد ۲۰ گرم",{"code":144,"en":145,"fa":146},"52512","SILDENAFIL (AS CITRATE) TABLET, ORALLY DISINTEGRATING ORAL 50 mg","قرص بازشونده دهانی سیلدنافیل (معادل سیترات) بازشونده ۵۰ میلی‌گرم",{"code":148,"en":149,"fa":150},"52511","SILDENAFIL (AS CITRATE) TABLET, ORALLY DISINTEGRATING ORAL 25 mg","قرص بازشونده دهانی سیلدنافیل (معادل سیترات) بازشونده ۲۵ میلی‌گرم",[152],{"source":153,"section":154,"url":155},"darooyab-generic","G-4223\u002FSildenafil","https:\u002F\u002Fwww.darooyab.ir\u002FG-4223\u002FSildenafil",[157,161,165,168,171],{"kind":158,"url":159,"label":160},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=209302","ANDA209302",{"kind":162,"url":163,"label":164},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=90477a51-63ba-43f4-a74b-4659a946093c","FDA Sildenafil",{"kind":166,"url":167,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa699015.html",{"kind":169,"url":170,"label":115},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G04BE03",{"kind":172,"url":155,"label":8},"darooyab",{"pregnancy":174,"lactation":183,"pediatric":190,"geriatric":197},{"level":175,"text":176,"quote":179,"refs":180},"caution",{"fa":177,"en":178},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Sildenafil is not indicated for use in females.",[181],{"source":33,"section":182},"8.1",{"level":175,"text":184,"quote":179,"refs":187},{"fa":185,"en":186},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.",[188],{"source":33,"section":189},"8.2",{"level":175,"text":191,"quote":194,"refs":195},{"fa":192,"en":193},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness have not been established in pediatric patients.",[196],{"source":33,"section":101},{"level":175,"text":198,"quote":201,"refs":202},{"fa":199,"en":200},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil resulting in approximately 84% and 107% higher plasma AUC values of sildenafil and its active N-desmethyl metabolite, respectively, compared to those seen in healthy young volunteers (18-45 years) [ see Clinical Pharmacology (12.3) ].",[203],{"source":33,"section":204},"8.5",{"kind":206,"refs":207,"id":160},"ANDA",[208],{"source":33,"section":209},"SPL approval \u002F marketing category",1792191871512]