[{"data":1,"prerenderedAt":290},["ShallowReactive",2],{"drug-streptomycin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":16,"formulations":17,"regimens":32,"contraindications":181,"warnings":191,"renal":201,"monitoring":202,"interactions":203,"review":204,"examples":207,"atc":230,"iran":232,"usApproval":244,"links":250,"populations":263},"streptomycin",1,{"fa":7,"en":8},"استرپتومایسین","Streptomycin","anti-infectives",{"fa":11,"en":12},"آمینوگلیکوزید","Aminoglycoside",[14],{"name":8,"market":15},"US",[4,7],[18],{"id":19,"form":20,"route":21,"label":22,"concentration":23,"markets":27,"refs":28},"vial-1g","powder-for-injection","im","1 g vial (IM after reconstitution)",{"amount":24,"unit":25,"perUnit":26},1000,"mg","vial",[15],[29],{"source":30,"section":31},"fda-streptomycin","How Supplied",[33,63,84,111,131,156],{"id":34,"disease":35,"label":36,"population":39,"type":43,"unit":25,"dose":44,"refs":47,"limits":50,"notes":54},"adult","brucellosis",{"fa":37,"en":38},"بروسلوز و سایر عفونت‌ها — بزرگسال: ۱ تا ۲ g در روز در دوزهای منقسم (عضلانی)","Brucellosis and other infections — adult: 1–2 g\u002Fday in divided doses (IM)",{"minAge":40},{"value":41,"unit":42},18,"year","fixed",{"perDose":45,"perDoseMax":24,"dosesPerDay":46},500,2,[48],{"source":30,"section":49},"Dosage and Administration — Other Infections",{"maxPerDay":51,"refs":52},2000,[53],{"source":30,"section":49},[55],{"text":56,"refs":59},{"fa":57,"en":58},"هر ۶ تا ۱۲ ساعت؛ معمولاً بیش از ۲ g در روز نشود. بالای ۶۰ سال و نارسایی کلیه دوز کمتر.","Every 6–12 h; generally not over 2 g\u002Fday. Reduce over 60 y and in renal impairment.",[60,61],{"source":30,"section":49},{"source":30,"section":62},"Dosage and Administration",{"id":64,"disease":35,"label":65,"population":68,"type":70,"unit":25,"dose":71,"refs":74,"notes":76},"child",{"fa":66,"en":67},"کودک — ۲۰ تا ۴۰ mg\u002Fkg\u002Fروز در دوزهای منقسم هر ۶ تا ۱۲ ساعت","Child — 20–40 mg\u002Fkg\u002Fday in divided doses every 6–12 h",{"maxAge":69},{"value":41,"unit":42},"weightBased",{"perKgPerDay":72,"perKgPerDayMax":73,"dividedDoses":46},20,40,[75],{"source":30,"section":49},[77],{"text":78,"refs":81},{"fa":79,"en":80},"از دوز بیش از حد در کودک به‌ویژه پرهیز شود (افسردگی CNS در شیرخوار).","Take particular care to avoid excessive doses in children (CNS depression in infants).",[82,83],{"source":30,"section":49},{"source":30,"section":62},{"id":85,"disease":86,"label":87,"population":90,"type":43,"unit":25,"dose":92,"refs":93,"limits":95,"notes":98},"plague-adult","plague",{"fa":88,"en":89},"طاعون — بزرگسال: ۱ تا ۲ g در روز در دوزهای منقسم (عضلانی)","Plague — adult: 1–2 g\u002Fday in divided doses (IM)",{"minAge":91},{"value":41,"unit":42},{"perDose":45,"perDoseMax":24,"dosesPerDay":46},[94],{"source":30,"section":49},{"maxPerDay":51,"refs":96},[97],{"source":30,"section":49},[99,104],{"text":100,"refs":101},{"fa":57,"en":58},[102,103],{"source":30,"section":49},{"source":30,"section":62},{"text":105,"refs":108},{"fa":106,"en":107},"برچسب استرپتومایسین «یرسینیا پستیس (طاعون)» را در موارد مصرف آورده (وقتی داروی کم‌خطرتر مناسب نیست)؛ دوز عمومی «سایر عفونت‌ها».","The streptomycin label lists “Yersinia pestis (plague)” (when less toxic agents are not suitable); general “other infections” dosing.",[109],{"source":30,"section":110},"Indications and Usage",{"id":112,"disease":86,"label":113,"population":116,"type":70,"unit":25,"dose":118,"refs":119,"notes":121},"plague-child",{"fa":114,"en":115},"طاعون — کودک: ۲۰ تا ۴۰ mg\u002Fkg\u002Fروز در دوزهای منقسم","Plague — child: 20–40 mg\u002Fkg\u002Fday in divided doses",{"maxAge":117},{"value":41,"unit":42},{"perKgPerDay":72,"perKgPerDayMax":73,"dividedDoses":46},[120],{"source":30,"section":49},[122,127],{"text":123,"refs":124},{"fa":79,"en":80},[125,126],{"source":30,"section":49},{"source":30,"section":62},{"text":128,"refs":129},{"fa":106,"en":107},[130],{"source":30,"section":110},{"id":132,"disease":132,"label":133,"population":136,"type":43,"unit":25,"dose":138,"refs":139,"limits":141,"notes":144},"chancroid",{"fa":134,"en":135},"شانکروئید — بزرگسال (دوز عمومی برچسب)","Chancroid — adult (general label dose)",{"minAge":137},{"value":41,"unit":42},{"perDose":45,"perDoseMax":24,"dosesPerDay":46},[140],{"source":30,"section":49},{"maxPerDay":51,"refs":142},[143],{"source":30,"section":49},[145,150],{"text":146,"refs":147},{"fa":57,"en":58},[148,149],{"source":30,"section":49},{"source":30,"section":62},{"text":151,"refs":154},{"fa":152,"en":153},"برچسب استرپتومایسین «هموفیلوس دوکره‌ای (شانکروئید)» را در موارد مصرف آورده (وقتی داروی کم‌خطرتر مناسب نیست)؛ دوز عمومی «سایر عفونت‌ها».","The streptomycin label lists “H. ducreyi (chancroid)” (when less toxic agents are not suitable); general “other infections” dosing.",[155],{"source":30,"section":110},{"id":157,"disease":157,"label":158,"population":161,"type":43,"unit":25,"dose":163,"refs":164,"limits":166,"notes":169},"donovanosis",{"fa":159,"en":160},"گرانولوم اینگوینال — بزرگسال (دوز عمومی برچسب)","Granuloma inguinale — adult (general label dose)",{"minAge":162},{"value":41,"unit":42},{"perDose":45,"perDoseMax":24,"dosesPerDay":46},[165],{"source":30,"section":49},{"maxPerDay":51,"refs":167},[168],{"source":30,"section":49},[170,175],{"text":171,"refs":172},{"fa":57,"en":58},[173,174],{"source":30,"section":49},{"source":30,"section":62},{"text":176,"refs":179},{"fa":177,"en":178},"برچسب استرپتومایسین «کالیماتوباکتریوم گرانولوماتیس (دونووانوز)» را در موارد مصرف آورده (وقتی داروی کم‌خطرتر مناسب نیست)؛ دوز عمومی «سایر عفونت‌ها».","The streptomycin label lists “Calymmatobacterium granulomatis (donovanosis)” (when less toxic agents are not suitable); general “other infections” dosing.",[180],{"source":30,"section":110},[182],{"id":183,"severity":184,"text":185,"refs":188},"hyper","block",{"fa":186,"en":187},"سابقه حساسیت به استرپتومایسین یا سایر آمینوگلیکوزیدها.","History of hypersensitivity to streptomycin or other aminoglycosides.",[189],{"source":30,"section":190},"Contraindications",[192],{"text":193,"refs":196},{"fa":194,"en":195},"هشدار جعبه‌ای: خطر سمیت عصبی شدید (اختلال تعادل و شنوایی، عصب بینایی، نوریت محیطی، انسفالوپاتی) در نارسایی کلیه یا ازوتمی پیش‌کلیوی به‌شدت بیشتر است؛ عملکرد کلیه و شنوایی پایش شود.","Boxed warning: risk of severe neurotoxicity (vestibular and cochlear dysfunction, optic nerve dysfunction, peripheral neuritis, encephalopathy) is sharply increased with impaired renal function or prerenal azotaemia; monitor renal function and hearing.",[197,199],{"source":30,"section":198},"Boxed Warning",{"source":30,"section":200},"Warnings",[],[],[],{"status":205,"reviewer":206,"date":206},"unverified",null,[208,212,218,221,224,227],{"regimen":34,"formulation":19,"input":209,"expect":211},{"ageYears":73,"weightKg":210},70,{"perDose":45,"upperPerDose":24},{"regimen":64,"formulation":19,"input":213,"expect":215},{"ageYears":214,"weightKg":72},6,{"perDose":216,"upperPerDose":217},200,400,{"regimen":85,"formulation":19,"input":219,"expect":220},{"ageYears":73,"weightKg":210},{"perDose":45,"upperPerDose":24},{"regimen":112,"formulation":19,"input":222,"expect":223},{"ageYears":214,"weightKg":72},{"perDose":216,"upperPerDose":217},{"regimen":132,"formulation":19,"input":225,"expect":226},{"ageYears":73,"weightKg":210},{"perDose":45,"upperPerDose":24},{"regimen":157,"formulation":19,"input":228,"expect":229},{"ageYears":73,"weightKg":210},{"perDose":45,"upperPerDose":24},[231],"J01GA01",{"status":233,"forms":234,"refs":239},"registered",[235],{"code":236,"en":237,"fa":238},"01173","STREPTOMYCIN SULFATE 1 G VIAL","ویال سترپتومایسین سولفات ۱ گرم",[240],{"source":241,"section":242,"url":243},"darooyab-generic","G-506\u002FStreptomycin","https:\u002F\u002Fwww.darooyab.ir\u002FG-506\u002FStreptomycin",{"kind":245,"refs":246,"id":249},"ANDA",[247],{"source":30,"section":248},"SPL approval \u002F marketing category","ANDA064210",[251,254,258,261],{"kind":252,"url":253,"label":249},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=064210",{"kind":255,"url":256,"label":257},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=abd1f64e-4283-4370-aae8-3666316aa36e","FDA Streptomycin",{"kind":259,"url":260,"label":231},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01GA01",{"kind":262,"url":243,"label":8},"darooyab",{"pregnancy":264,"lactation":273,"pediatric":282},{"level":265,"text":266,"quote":269,"refs":270},"caution",{"fa":267,"en":268},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","See WARNINGS section.",[271],{"source":30,"section":272},"Pregnancy",{"level":274,"text":275,"quote":278,"refs":279},"avoid",{"fa":276,"en":277},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in nursing infants from streptomycin, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[280],{"source":30,"section":281},"Nursing Mothers",{"level":265,"text":283,"quote":286,"refs":287},{"fa":284,"en":285},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","See DOSAGE AND ADMINISTRATION .",[288],{"source":30,"section":289},"Pediatric Use",1792440730285]