[{"data":1,"prerenderedAt":219},["ShallowReactive",2],{"drug-tadalafil":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":51,"contraindications":93,"warnings":113,"renal":114,"monitoring":115,"interactions":116,"review":117,"examples":120,"atc":130,"iran":132,"links":156,"populations":173,"usApproval":214},"tadalafil",1,{"fa":7,"en":8},"تادالافیل","Tadalafil","genitourinary-sex-hormones",{"fa":11,"en":12},"مهارکننده PDE5","PDE5 inhibitor",[14],{"name":15,"market":16},"Cialis","US",[18,19,7],"cialis","سیالیس",[21,35,43],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-5","tablet","oral","5 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},5,"mg",false,[16],[32],{"source":33,"section":34},"fda-tadalafil","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-10","10 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},10,[16],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":48,"refs":49},"tab-20","20 mg tablet",{"amount":47,"unit":28,"perUnit":23,"scored":29},20,[16],[50],{"source":33,"section":34},[52,80],{"id":53,"disease":54,"label":55,"population":58,"type":62,"unit":28,"dose":63,"refs":64,"limits":67,"notes":71},"ed-prn","erectile-dysfunction",{"fa":56,"en":57},"اختلال نعوظ (در صورت نیاز) — شروع ۱۰ mg","ED (as needed) — start 10 mg",{"minAge":59},{"value":60,"unit":61},18,"year","fixed",{"perDose":39,"dosesPerDay":5},[65],{"source":33,"section":66},"2.1",{"maxPerDay":47,"refs":68},[69],{"source":33,"section":70},"2",[72],{"text":73,"refs":76},{"fa":74,"en":75},"۵ تا ۲۰ mg؛ CrCl ۳۰ تا ۵۰: شروع ۵ mg و حداکثر ۱۰ mg هر ۴۸ ساعت.","5–20 mg; CrCl 30–50: start 5 mg, max 10 mg per 48 h.",[77,78],{"source":33,"section":70},{"source":33,"section":79},"2.6",{"id":81,"disease":81,"label":82,"population":85,"type":62,"unit":28,"dose":87,"refs":88},"bph",{"fa":83,"en":84},"BPH (± اختلال نعوظ) — ۵ mg یک بار در روز","BPH (± ED) — 5 mg once daily",{"minAge":86},{"value":60,"unit":61},{"perDose":27,"dosesPerDay":5},[89,91],{"source":33,"section":90},"2.3",{"source":33,"section":92},"2.4",[94,103],{"id":95,"severity":96,"text":97,"refs":100},"nitrates","block",{"fa":98,"en":99},"همراه هر نوع نیترات (نیتروگلیسیرین، ایزوسورباید) یا محرک‌های گوانیلات سیکلاز (ریوسیگوات): افت شدید فشار.","With any nitrate (nitroglycerin, isosorbide) or guanylate-cyclase stimulators (riociguat): severe hypotension.",[101],{"source":33,"section":102},"4",{"id":104,"severity":96,"rule":105,"text":107,"refs":110},"child",{"maxAge":106},{"value":60,"unit":61},{"fa":108,"en":109},"زیر ۱۸ سال ثابت نشده.","Not established under 18.",[111],{"source":33,"section":112},"8.4",[],[],[],[],{"status":118,"reviewer":119,"date":119},"unverified",null,[121,126],{"regimen":53,"formulation":36,"input":122,"expect":125},{"ageYears":123,"weightKg":124},50,80,{"perDose":39},{"regimen":81,"formulation":22,"input":127,"expect":129},{"ageYears":128,"weightKg":124},60,{"perDose":27},[131],"G04BE08",{"status":133,"forms":134,"refs":151},"registered",[135,139,143,147],{"code":136,"en":137,"fa":138},"06974","TADALAFIL 10MG TAB","قرص تادالافیل ۱۰ میلی‌گرم",{"code":140,"en":141,"fa":142},"06975","TADALAFIL 20MG TAB","قرص تادالافیل ۲۰ میلی‌گرم",{"code":144,"en":145,"fa":146},"52889","TADALAFIL 2.5MG TAB","قرص تادالافیل ۲٫۵ میلی‌گرم",{"code":148,"en":149,"fa":150},"51681","TADALAFIL 5MG TAB","قرص تادالافیل ۵ میلی‌گرم",[152],{"source":153,"section":154,"url":155},"darooyab-generic","G-4274\u002FTadalafil","https:\u002F\u002Fwww.darooyab.ir\u002FG-4274\u002FTadalafil",[157,161,165,168,171],{"kind":158,"url":159,"label":160},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=205885","ANDA205885",{"kind":162,"url":163,"label":164},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=3ad14d63-42e7-493f-b56c-e02a4fd139f7","FDA Tadalafil",{"kind":166,"url":167,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa604008.html",{"kind":169,"url":170,"label":131},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G04BE08",{"kind":172,"url":155,"label":8},"darooyab",{"pregnancy":174,"lactation":183,"pediatric":190,"geriatric":198,"reproductive":206},{"level":175,"text":176,"quote":179,"refs":180},"caution",{"fa":177,"en":178},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Tadalafil tablets are not indicated for use in females.",[181],{"source":33,"section":182},"8.1",{"level":175,"text":184,"quote":179,"refs":187},{"fa":185,"en":186},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.",[188],{"source":33,"section":189},"8.2",{"level":191,"text":192,"quote":195,"refs":196},"not-established",{"fa":193,"en":194},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Tadalafil tablets are not indicated for use in pediatric patients.",[197],{"source":33,"section":112},{"level":175,"text":199,"quote":202,"refs":203},{"fa":200,"en":201},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","However, a greater sensitivity to medications in some older individuals should be considered [see Clinical Pharmacology ( 12.3 )] .",[204],{"source":33,"section":205},"8.5",{"level":175,"text":207,"quote":210,"refs":211},{"fa":208,"en":209},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Based on the data from 3 studies in adult males, tadalafil decreased sperm concentrations in the study of 10 mg tadalafil for 6 months and the study of 20 mg tadalafil for 9 months.",[212],{"source":33,"section":213},"8.3",{"kind":215,"refs":216,"id":160},"ANDA",[217],{"source":33,"section":218},"SPL approval \u002F marketing category",1792191871528]