[{"data":1,"prerenderedAt":288},["ShallowReactive",2],{"drug-theophylline":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":36,"contraindications":143,"warnings":153,"renal":161,"monitoring":162,"interactions":163,"review":164,"examples":167,"atc":190,"iran":192,"links":232,"populations":249,"usApproval":283},"theophylline",1,{"fa":7,"en":8},"تئوفیلین","Theophylline","respiratory",{"fa":11,"en":12},"متیل‌گزانتین؛ برونکودیلاتور","Methylxanthine bronchodilator",[14],{"name":15,"market":16},"Elixophyllin","US",[18,19,20],"theophyllin","تئوفیلین جی","theophylline g",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"sol-80-15","solution","oral","80 mg \u002F 15 mL",{"amount":28,"unit":29,"perVolumeMl":30},80,"mg",15,[16],[33],{"source":34,"section":35},"fda-theophylline-sol","Description",[37,68,88,109,129],{"id":38,"disease":39,"label":40,"population":43,"type":49,"unit":29,"dose":50,"refs":54,"limits":57,"notes":61},"child-step1","asthma",{"fa":41,"en":42},"کودکان ۱ تا ۱۵ سال، زیر ۴۵ کیلوگرم — شروع: ۱۲ تا ۱۴ mg\u002Fkg\u002Fday","Children 1–15 y, \u003C45 kg — start: 12–14 mg\u002Fkg\u002Fday",{"minAge":44,"maxAge":46,"maxWeightKg":48},{"value":5,"unit":45},"year",{"value":47,"unit":45},16,45,"weightBased",{"perKgPerDay":51,"perKgPerDayMax":52,"dividedDoses":53},12,14,4,[55],{"source":34,"section":56},"Dosage and Administration, Table V",{"maxPerDay":58,"refs":59},300,[60],{"source":34,"section":56},[62],{"text":63,"refs":66},{"fa":64,"en":65},"در عوامل خطر کاهش کلیرانس یا وقتی پایش سطح سرمی ممکن نیست، دوز نهایی کودکان ۱ تا ۱۵ سال از ۱۶ mg\u002Fkg\u002Fday (حداکثر ۴۰۰ mg\u002Fday) بیشتر نشود. حاشیه درمانی باریک؛ پایش سطح سرمی.","With risk factors for reduced clearance or if serum levels cannot be monitored, the final dose for 1–15 years must not exceed 16 mg\u002Fkg\u002Fday (max 400 mg\u002Fday). Narrow therapeutic index; monitor serum levels.",[67],{"source":34,"section":56},{"id":69,"disease":39,"label":70,"population":73,"type":49,"unit":29,"dose":76,"refs":77,"limits":79,"notes":83},"child-step2",{"fa":71,"en":72},"کودکان زیر ۴۵ کیلوگرم — پس از ۳ روز: ۱۶ mg\u002Fkg\u002Fday","Children \u003C45 kg — after 3 days: 16 mg\u002Fkg\u002Fday",{"minAge":74,"maxAge":75,"maxWeightKg":48},{"value":5,"unit":45},{"value":47,"unit":45},{"perKgPerDay":47,"dividedDoses":53},[78],{"source":34,"section":56},{"maxPerDay":80,"refs":81},400,[82],{"source":34,"section":56},[84],{"text":85,"refs":86},{"fa":64,"en":65},[87],{"source":34,"section":56},{"id":89,"disease":39,"label":90,"population":93,"type":49,"unit":29,"dose":96,"refs":98,"limits":100,"notes":104},"child-step3",{"fa":91,"en":92},"کودکان زیر ۴۵ کیلوگرم — پس از ۳ روز دیگر: ۲۰ mg\u002Fkg\u002Fday","Children \u003C45 kg — after 3 more days: 20 mg\u002Fkg\u002Fday",{"minAge":94,"maxAge":95,"maxWeightKg":48},{"value":5,"unit":45},{"value":47,"unit":45},{"perKgPerDay":97,"dividedDoses":53},20,[99],{"source":34,"section":56},{"maxPerDay":101,"refs":102},600,[103],{"source":34,"section":56},[105],{"text":106,"refs":107},{"fa":64,"en":65},[108],{"source":34,"section":56},{"id":110,"disease":39,"label":111,"population":114,"type":115,"unit":29,"dose":116,"refs":120,"notes":122},"adult",{"fa":112,"en":113},"بیش از ۴۵ کیلوگرم و بزرگسال — شروع ۳۰۰ mg\u002Fday",">45 kg and adults — start 300 mg\u002Fday",{"minWeightKg":48},"titration",{"dividedDoses":53,"titration":117},{"start":58,"increment":118,"incrementEveryDays":119,"targetMin":80,"targetMax":101,"max":101},100,3,[121],{"source":34,"section":56},[123],{"text":124,"refs":127},{"fa":125,"en":126},"۳۰۰ ← ۴۰۰ ← ۶۰۰ mg\u002Fday هر ۳ روز در صورت تحمل، در دوزهای هر ۶ تا ۸ ساعت. با عوامل خطر یا بالای ۶۰ سال حداکثر ۴۰۰ mg\u002Fday.","300 → 400 → 600 mg\u002Fday every 3 days if tolerated, divided every 6–8 h. With risk factors or over 60 years, max 400 mg\u002Fday.",[128],{"source":34,"section":56},{"id":130,"disease":39,"label":131,"population":134,"type":136,"unit":29,"dose":137,"refs":141},"infant",{"fa":132,"en":133},"شیرخوار زیر ۱ سال","Infants under 1 year",{"maxAge":135},{"value":5,"unit":45},"notCalculated",{"reason":138},{"fa":139,"en":140},"فرمول برچسب: دوز روزانه (mg) = [(۰٫۲ × سن به هفته) + ۵] × وزن (kg)؛ زیر ۲۶ هفته در ۳ نوبت، ۲۶ هفته به بالا در ۴ نوبت. نوزاد نارس: ۱ تا ۱٫۵ mg\u002Fkg هر ۱۲ ساعت. تنظیم با سطح سرمی؛ محاسبه خودکار انجام نمی‌شود.","Label formula: total daily dose (mg) = [(0.2 × age in weeks) + 5] × kg; \u003C26 weeks in 3 doses, ≥26 weeks in 4 doses. Premature neonates: 1–1.5 mg\u002Fkg every 12 h. Titrate to serum level; not auto-calculated.",[142],{"source":34,"section":56},[144],{"id":145,"severity":146,"text":147,"refs":150},"hypersensitivity","block",{"fa":148,"en":149},"حساسیت به تئوفیلین یا اجزای فرآورده.","Hypersensitivity to theophylline or other components.",[151],{"source":34,"section":152},"Contraindications",[154],{"text":155,"refs":158},{"fa":156,"en":157},"با احتیاط شدید در زخم پپتیک فعال، اختلال تشنجی و سایر بیماری‌های همزمان.","Use with extreme caution in active peptic ulcer disease, seizure disorders and other concurrent illness.",[159],{"source":34,"section":160},"Warnings",[],[],[],{"status":165,"reviewer":166,"date":166},"unverified",null,[168,175,178,181,185],{"regimen":38,"formulation":23,"input":169,"expect":171},{"ageYears":170,"weightKg":97},6,{"perDose":172,"upperPerDose":173,"mlPerDose":174},60,70,11.25,{"regimen":69,"formulation":23,"input":176,"expect":177},{"ageYears":170,"weightKg":97},{"perDose":28,"mlPerDose":30},{"regimen":89,"formulation":23,"input":179,"expect":180},{"ageYears":170,"weightKg":97},{"perDose":118,"perDay":80},{"regimen":89,"formulation":23,"input":182,"expect":184},{"ageYears":52,"weightKg":183},40,{"perDay":101},{"regimen":110,"formulation":23,"input":186,"expect":188},{"ageYears":187,"weightKg":173},30,{"perDose":189},75,[191],"R03DA04",{"status":193,"forms":194,"refs":227},"registered",[195,199,203,207,211,215,219,223],{"code":196,"en":197,"fa":198},"02403","THEOPHYLLINE 100MG RET TAB","قرص تئوفیلین ۱۰۰ میلی‌گرم RET",{"code":200,"en":201,"fa":202},"01691","THEOPHYLLINE 100MG TAB","قرص تئوفیلین ۱۰۰ میلی‌گرم",{"code":204,"en":205,"fa":206},"02203","THEOPHYLLINE 200MG RET CAP","کپسول تئوفیلین ۲۰۰ میلی‌گرم RET",{"code":208,"en":209,"fa":210},"01209","THEOPHYLLINE 200MG RET TAB","قرص تئوفیلین ۲۰۰ میلی‌گرم RET",{"code":212,"en":213,"fa":214},"01210","THEOPHYLLINE 200MG TAB","قرص تئوفیلین ۲۰۰ میلی‌گرم",{"code":216,"en":217,"fa":218},"52437","THEOPHYLLINE CAPSULE, COATED, EXTENDED RELEASE ORAL 100 mg","کپسول آهسته‌رهش تئوفیلین ۱۰۰ میلی‌گرم",{"code":220,"en":221,"fa":222},"52438","THEOPHYLLINE CAPSULE, COATED, EXTENDED RELEASE ORAL 300 mg","کپسول آهسته‌رهش تئوفیلین ۳۰۰ میلی‌گرم",{"code":224,"en":225,"fa":226},"52439","THEOPHYLLINE CAPSULE, COATED, EXTENDED RELEASE ORAL 400 mg","کپسول آهسته‌رهش تئوفیلین ۴۰۰ میلی‌گرم",[228],{"source":229,"section":230,"url":231},"darooyab-generic","G-1496\u002FTheophylline","https:\u002F\u002Fwww.darooyab.ir\u002FG-1496\u002FTheophylline",[233,237,241,244,247],{"kind":234,"url":235,"label":236},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=091156","ANDA091156",{"kind":238,"url":239,"label":240},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=1b685384-5d96-46fa-b93b-e96538a2cfe7","FDA Theophylline sol",{"kind":242,"url":243,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa681006.html",{"kind":245,"url":246,"label":191},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=R03DA04",{"kind":248,"url":231,"label":8},"darooyab",{"pregnancy":250,"lactation":259,"pediatric":267,"geriatric":275},{"level":251,"text":252,"quote":255,"refs":256},"caution",{"fa":253,"en":254},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","There are no adequate and well controlled studies in pregnant women.",[257],{"source":34,"section":258},"Precautions\u002FWarnings – Pregnancy",{"level":251,"text":260,"quote":263,"refs":264},{"fa":261,"en":262},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants.",[265],{"source":34,"section":266},"Precautions\u002FWarnings – Nursing Mothers",{"level":251,"text":268,"quote":271,"refs":272},{"fa":269,"en":270},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Theophylline is safe and effective for the approved indications in pediatric patients (See INDICATIONS AND USAGE ).",[273],{"source":34,"section":274},"Precautions\u002FWarnings – Pediatric Use",{"level":251,"text":276,"quote":279,"refs":280},{"fa":277,"en":278},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Theophylline clearance is reduced in patients greater than 60 years of age, resulting in increased serum theophylline concentrations in response to a given theophylline dose.",[281],{"source":34,"section":282},"Precautions\u002FWarnings – Geriatric Use",{"kind":284,"refs":285,"id":236},"ANDA",[286],{"source":34,"section":287},"SPL approval \u002F marketing category",1792440741427]