[{"data":1,"prerenderedAt":340},["ShallowReactive",2],{"drug-valproic-acid":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":38,"contraindications":88,"warnings":117,"renal":118,"monitoring":119,"interactions":120,"review":121,"examples":124,"atc":140,"iran":142,"links":274,"populations":293,"usApproval":335},"valproic-acid",1,{"fa":7,"en":8},"والپروئیک اسید (شربت)","Valproic acid (oral solution)","nervous-system",{"fa":11,"en":12},"ضدتشنج","Anticonvulsant",[14],{"name":15,"market":16},"Depakene","US",[18,19,20,21,22],"depakene","دپاکین","والپروات","والپروات سدیم","شربت والپروات",[24],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"sol-250","solution","oral","250 mg\u002F5 mL oral solution",{"amount":30,"unit":31,"perVolumeMl":32},250,"mg",5,[16],[35],{"source":36,"section":37},"fda-valproicsol","3",[39,67],{"id":40,"disease":41,"label":42,"population":45,"type":49,"unit":31,"dose":50,"refs":53,"limits":56,"notes":60},"cps","epilepsy",{"fa":43,"en":44},"صرع پارشیل پیچیده — ۱۰ سال به بالا: شروع ۱۰ تا ۱۵ mg\u002Fkg\u002Fday","Complex partial seizures — ≥10 y: start 10–15 mg\u002Fkg\u002Fday",{"minAge":46},{"value":47,"unit":48},10,"year","weightBased",{"perKgPerDay":47,"perKgPerDayMax":51,"dividedDoses":52},15,2,[54],{"source":36,"section":55},"2.1",{"maxPerKgPerDay":57,"refs":58},60,[59],{"source":36,"section":55},[61],{"text":62,"refs":65},{"fa":63,"en":64},"افزایش ۵ تا ۱۰ mg\u002Fkg\u002Fهفته؛ معمولاً پاسخ زیر ۶۰ mg\u002Fkg\u002Fday؛ سطح خونی ۵۰ تا ۱۰۰ mcg\u002FmL. اگر بیش از ۲۵۰ mg\u002Fday، منقسم.","Increase by 5–10 mg\u002Fkg\u002Fweek; usual response below 60 mg\u002Fkg\u002Fday; levels 50–100 mcg\u002FmL. Divide if >250 mg\u002Fday.",[66],{"source":36,"section":55},{"id":68,"disease":41,"label":69,"population":72,"type":49,"unit":31,"dose":74,"refs":75,"limits":78,"notes":81},"absence",{"fa":70,"en":71},"صرع ابسانس — شروع ۱۵ mg\u002Fkg\u002Fday","Absence seizures — start 15 mg\u002Fkg\u002Fday",{"minAge":73},{"value":52,"unit":48},{"perKgPerDay":51,"dividedDoses":52},[76],{"source":36,"section":77},"2",{"maxPerKgPerDay":57,"refs":79},[80],{"source":36,"section":77},[82],{"text":83,"refs":86},{"fa":84,"en":85},"افزایش هفتگی ۵ تا ۱۰ mg\u002Fkg؛ بی‌خطری بالای ۶۰ mg\u002Fkg\u002Fday ثابت نشده.","Increase by 5–10 mg\u002Fkg weekly; safety above 60 mg\u002Fkg\u002Fday not established.",[87],{"source":36,"section":77},[89,100,108],{"id":90,"severity":91,"rule":92,"text":94,"refs":97},"under-2","block",{"maxAge":93},{"value":52,"unit":48},{"fa":95,"en":96},"زیر ۲ سال خطر کشنده آسیب کبدی بسیار بالاتر است.","Under 2 years: considerably higher risk of fatal hepatotoxicity.",[98],{"source":36,"section":99},"8.4",{"id":101,"severity":91,"text":102,"refs":105},"ci",{"fa":103,"en":104},"بیماری یا اختلال قابل‌توجه کبد؛ اختلال میتوکندریایی POLG؛ حساسیت؛ اختلال چرخه اوره؛ برای پیشگیری میگرن: بارداری یا عدم پیشگیری مؤثر.","Hepatic disease or significant dysfunction; POLG mitochondrial disorders; hypersensitivity; urea-cycle disorders; for migraine prophylaxis: pregnancy or no effective contraception.",[106],{"source":36,"section":107},"4",{"id":109,"severity":110,"text":111,"refs":114},"boxed","warn",{"fa":112,"en":113},"هشدار جعبه‌ای: سمیت کبدی، تراتوژنیسیته، پانکراتیت.","Boxed warning: hepatotoxicity, teratogenicity, pancreatitis.",[115],{"source":36,"section":116},"Boxed Warning",[],[],[],[],{"status":122,"reviewer":123,"date":123},"unverified",null,[125,133],{"regimen":40,"formulation":25,"input":126,"expect":129},{"ageYears":127,"weightKg":128},12,40,{"perDose":130,"mlPerDose":131,"upperPerDose":132},200,4,300,{"regimen":68,"formulation":25,"input":134,"expect":137},{"ageYears":135,"weightKg":136},6,20,{"perDose":138,"mlPerDose":139},150,3,[141],"N03AG01",{"status":143,"forms":144,"refs":269},"registered",[145,149,153,157,161,165,169,173,177,181,185,189,193,197,201,205,209,213,217,221,225,229,233,237,241,245,249,253,257,261,265],{"code":146,"en":147,"fa":148},"11636","DIVALPROEX (VALPROATE SEMISODIUM) 125MG TAB","قرص دی‌والپروکس (والپروات سمی‌سدیم) ۱۲۵ میلی‌گرم",{"code":150,"en":151,"fa":152},"11614","DIVALPROEX (VALPROATE SEMISODIUM) 250MG TAB","قرص دی‌والپروکس (والپروات سمی‌سدیم) ۲۵۰ میلی‌گرم",{"code":154,"en":155,"fa":156},"11611","DIVALPROEX (VALPROATE SEMISODIUM) 500MG TAB","قرص دی‌والپروکس (والپروات سمی‌سدیم) ۵۰۰ میلی‌گرم",{"code":158,"en":159,"fa":160},"11366","VALPROATE SODIUM 100MG\u002FML 10ML AMP","آمپول والپروات سدیم ۱۰۰ میلی‌گرم \u002F میلی‌لیتر ۱۰ میلی‌لیتر",{"code":162,"en":163,"fa":164},"11367","VALPROATE SODIUM 100MG\u002FML 3ML AMP","آمپول والپروات سدیم ۱۰۰ میلی‌گرم \u002F میلی‌لیتر ۳ میلی‌لیتر",{"code":166,"en":167,"fa":168},"17568","VALPROATE SODIUM 100MG\u002FML 5ML INJ","فرآورده تزریقی والپروات سدیم ۱۰۰ میلی‌گرم \u002F میلی‌لیتر ۵ میلی‌لیتر",{"code":170,"en":171,"fa":172},"07763","VALPROATE SODIUM 150MG CAP","کپسول والپروات سدیم ۱۵۰ میلی‌گرم",{"code":174,"en":175,"fa":176},"01275","VALPROATE SODIUM 200MG TAB","قرص والپروات سدیم ۲۰۰ میلی‌گرم",{"code":178,"en":179,"fa":180},"07669","VALPROATE SODIUM 200MG\u002F5ML 120ML SYRUP","شربت والپروات سدیم ۲۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":182,"en":183,"fa":184},"02805","VALPROATE SODIUM 200MG\u002F5ML 240ML SYRUP","شربت والپروات سدیم ۲۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۲۴۰ میلی‌لیتر",{"code":186,"en":187,"fa":188},"06170","VALPROATE SODIUM 200MG\u002F5ML 300ML SYRUP","شربت والپروات سدیم ۲۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۳۰۰ میلی‌لیتر",{"code":190,"en":191,"fa":192},"09715","VALPROATE SODIUM 200MG\u002F5ML 40ML SYRUP","شربت والپروات سدیم ۲۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۴۰ میلی‌لیتر",{"code":194,"en":195,"fa":196},"01724","VALPROATE SODIUM 200MG\u002F5ML 60ML SYRUP","شربت والپروات سدیم ۲۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۶۰ میلی‌لیتر",{"code":198,"en":199,"fa":200},"11443","VALPROATE SODIUM 200MG\u002FML SYRUP","شربت والپروات سدیم ۲۰۰ میلی‌گرم \u002F میلی‌لیتر",{"code":202,"en":203,"fa":204},"11494","VALPROATE SODIUM 200ML SYRUP","شربت والپروات سدیم ۲۰۰ میلی‌لیتر",{"code":206,"en":207,"fa":208},"07127","VALPROATE SODIUM 250MG TAB","قرص والپروات سدیم ۲۵۰ میلی‌گرم",{"code":210,"en":211,"fa":212},"12290","VALPROATE SODIUM 300MG ER CAP","کپسول آهسته‌رهش والپروات سدیم ۳۰۰ میلی‌گرم",{"code":214,"en":215,"fa":216},"22182","VALPROATE SODIUM 300MG TAB","قرص والپروات سدیم 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میلی‌گرم",{"code":250,"en":251,"fa":252},"04577","VALPROATE SODIUM 500MG TAB","قرص والپروات سدیم ۵۰۰ میلی‌گرم",{"code":254,"en":255,"fa":256},"08020","VALPROATE SODIUM 50MG SR TAB","قرص آهسته‌رهش والپروات سدیم ۵۰ میلی‌گرم",{"code":258,"en":259,"fa":260},"21675","VALPROIC ACID 500MG SOFT GEL CAP","کپسول نرم والپرویک اسید ۵۰۰ میلی‌گرم",{"code":262,"en":263,"fa":264},"52223","VALPROATE SODIUM INJECTION PARENTERAL 100 mg\u002F1mL 4 mL","فرآورده تزریقی والپروات سدیم ۱۰۰ میلی‌گرم \u002F ۱ میلی‌لیتر ۴ میلی‌لیتر",{"code":266,"en":267,"fa":268},"52064","VALPROATE SODIUM SYRUP ORAL 200 mg\u002F5mL 250 mL","شربت والپروات سدیم ۲۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۲۵۰ میلی‌لیتر",[270],{"source":271,"section":272,"url":273},"darooyab-generic","G-690\u002FSodium-Valproate","https:\u002F\u002Fwww.darooyab.ir\u002FG-690\u002FSodium-Valproate",[275,279,283,287,290],{"kind":276,"url":277,"label":278},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=075379","ANDA075379",{"kind":280,"url":281,"label":282},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=7d5cb52e-37dd-4dfa-a6f4-09f9548846c6","FDA Valproic acid sol.",{"kind":284,"url":285,"label":286},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682412.html","Valproic Acid",{"kind":288,"url":289,"label":141},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N03AG01",{"kind":291,"url":273,"label":292},"darooyab","Sodium-Valproate",{"pregnancy":294,"lactation":302,"pediatric":311,"geriatric":319,"reproductive":327},{"level":295,"text":296,"quote":299,"refs":300},"contraindicated",{"fa":297,"en":298},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","For use in prophylaxis of migraine headaches: Valproic acid is contraindicated in women who are pregnant and in women of childbearing potential who are not using effective contraception [see Warnings and Precautions (5.2 , 5.3 , 5.4) and Use in Specific Populations (8.1) ] .",[301],{"source":36,"section":107},{"level":303,"text":304,"quote":307,"refs":308},"caution",{"fa":305,"en":306},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Valproate is excreted in human milk.",[309],{"source":36,"section":310},"8.2",{"level":312,"text":313,"quote":316,"refs":317},"avoid",{"fa":314,"en":315},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","Children under the age of two years and patients with mitochondrial disorders are at higher risk.",[318],{"source":36,"section":116},{"level":303,"text":320,"quote":323,"refs":324},{"fa":321,"en":322},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","A study of elderly patients with dementia revealed drug related somnolence and discontinuation for somnolence [see Warnings and Precautions (5.14) ] .",[325],{"source":36,"section":326},"8.5",{"level":303,"text":328,"quote":331,"refs":332},{"fa":329,"en":330},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Women of childbearing potential should use effective contraception while taking valproate [see Boxed Warning , Warnings and Precautions (5.4) , Drug Interactions (7) , and Use in Specific Populations (8.1) ] .",[333],{"source":36,"section":334},"8.3",{"kind":336,"refs":337,"id":278},"ANDA",[338],{"source":36,"section":339},"SPL approval \u002F marketing category",1792444714017]