Atrial fibrillation / anticoagulation

Non-valvular AF — 5 mg twice daily

Non-valvular AF — 150 mg twice daily

Conversion/maintenance of sinus rhythm in AF/AFL — by CrCl: >60 → 500 mcg; 40–60 → 250; 20–<40 → 125 mcg twice daily

Reduce hospitalisation in paroxysmal or persistent (non-permanent) AF — 400 mg twice daily with meals

Non-valvular AF — CrCl 50–95: 60 mg once daily

PAF or PSVT — 50 mg every 12 h, +50 mg twice daily every 4 days, max 300 mg/day

Paroxysmal AF without structural heart disease — 150 mg every 8 h (up to 900 mg/day)

Non-valvular AF — 20 mg once daily with the evening meal

Maintenance of sinus rhythm in AF/AFL — start 80 mg twice daily; most respond to 120 mg twice daily

Oral anticoagulation — INR-guided

Children