Chemotherapy-induced nausea and vomiting

CINV prevention (adults and ≥12 y) — day 1: 125 mg, 1 h before chemotherapy

Days 2 and 3: 80 mg once daily (in the morning if no chemotherapy)

CINV refractory to conventional antiemetics — start 5 mg/m² 1–3 h before chemotherapy, then every 2–4 h (4–6 doses/day)

CINV prevention, adults — 150 mg IV on day 1, infused over 20–30 min

Chemotherapy nausea prevention — 2 mg once (or 1 mg twice) on chemotherapy days only

Prevention of delayed CINV — 1–18 years: 0.1–0.15 mg/kg up to 3 times daily

Moderately emetogenic chemotherapy — 4–11 years: 4 mg

Moderately emetogenic chemotherapy — 12–17 years: 8 mg

Chemotherapy nausea — ≥6 months: 0.15 mg/kg IV, 3 doses (max 16 mg per dose)

CINV prevention, adults — 0.25 mg IV over 30 s, 30 min before chemotherapy

Children 1 month–<17 y — 20 mcg/kg (max 1.5 mg) over 15 min