Metoclopramide
متوکلوپرامید
🍽️ Alimentary Tract And MetabolismDopamine antagonist; prokinetic
Market / country: 🇬🇧 UK
Reglan (US) · Maxolon (GB)
🧮 Dose calculator
Chemotherapy-induced nausea and vomiting · Regimen source: UK SmPC Metoclopramide · 4.2
- • At least 6 h between doses, even after vomiting. Maximum 5 days. In children licensed only for this use. UK SmPC Metoclopramide · 4.2UK SmPC Metoclopramide · 4.4
Enter age and weight.
🛡️ Safety & information
Contraindications
- ⛔ Children under 1 year (risk of extrapyramidal disorders). UK SmPC Metoclopramide · 4.3
- ⛔ GI haemorrhage, obstruction or perforation; history of tardive dyskinesia; epilepsy; Parkinson's disease; phaeochromocytoma; with levodopa/dopamine agonists; history of methaemoglobinaemia. UK SmPC Metoclopramide · 4.3
Warnings
- • Extrapyramidal disorders, particularly in children and young adults, even after a single dose; stop immediately if they occur. UK SmPC Metoclopramide · 4.4
- • Tardive dyskinesia with prolonged use; do not exceed 3 months. Neuroleptic malignant syndrome. UK SmPC Metoclopramide · 4.4
Renal adjustment
- • eGFR < 60: CrCl 15–60: reduce dose 50%; ≤15: reduce daily dose 75%. UK SmPC Metoclopramide · 4.2
Formulations
- 5 mg / 5 mL oral solution — solution 🇬🇧 UK UK SmPC Metoclopramide · 1
👥 Special populations
- 🤰 PregnancyDangerous / avoid
Label: can cause fetal harm. Dangerous in pregnancy. UK SmPC Metoclopramide · 4.6
“Metoclopramide should be avoided at the end of pregnancy.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. UK SmPC Metoclopramide · 4.6
“Metoclopramide is excreted in breast milk at low level.”
- 👶 ChildrenContraindicated
Label: contraindicated in children below a stated age. UK SmPC Metoclopramide · 4.3
“… section 4.5). • Known history of methaemoglobinaemia with metoclopramide or of NADH cytochrome-b5 deficiency. • Use in children less than 1 year of age due to an increased risk of extrapyramidal disorders (see section 4.4).”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. UK SmPC Metoclopramide · 4.2
“Elderly In elderly patients a dose reduction should be considered, based on renal and hepatic function and overall frailty.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)❌ None
- DailyMed (FDA label)❌ None
- MedlinePlus (NIH)MetoclopramideMetoclopramide Injection
- WHO ATC/DDDA03FA01
- Darooyab (Iran)Metoclopramide
- eMC (UK label)UK SmPC Metoclopramide
🇮🇷 Registered in Iran Darooyab · G-2614/Metoclopramide
Dosage forms with Iranian generic codes, per Darooyab.
- 18780 · METOCLOPRAMIDE 10MG SOFT GEL CAP · کپسول نرم متوکلوپرامید ۱۰ میلیگرم
- 00841 · METOCLOPRAMIDE 10MG TAB · قرص متوکلوپرامید ۱۰ میلیگرم
- 00839 · METOCLOPRAMIDE 10MG/2ML AMP · آمپول متوکلوپرامید ۱۰ میلیگرم / ۲ میلیلیتر
- 00840 · METOCLOPRAMIDE 4MG/ML 15ML ORAL DROP · قطره خوراکی متوکلوپرامید ۴ میلیگرم / میلیلیتر ۱۵ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)❌ Not present
- UK SmPC (eMC / MHRA)✅ PresentUK SmPC Metoclopramide · 1UK SmPC Metoclopramide · 4.2UK SmPC Metoclopramide · 4.4UK SmPC Metoclopramide · 4.3UK SmPC Metoclopramide · 4.6
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-2614/Metoclopramide
- Clinical review⚠ Unverified