Epilepsy (complex partial / absence seizures)

Partial-onset seizures — ≥16 y: 50 mg twice daily (25–100 mg twice daily)

Child ≥50 kg — start 25–50 mg twice daily (up to 100 mg twice daily)

Child 20 to <50 kg — start 0.5–1 mg/kg twice daily (up to 2 mg/kg twice daily)

Child 11 to <20 kg — start 0.5–1.25 mg/kg twice daily (up to 2.5 mg/kg twice daily)

Child <11 kg (≥1 month) — start 0.75–1.5 mg/kg twice daily (up to 3 mg/kg twice daily)

Epilepsy — under 6 y: start 10–20 mg/kg/day

Epilepsy — 6–12 y: start 100 mg twice daily

Epilepsy — adults and >12 y: start 200 mg twice daily

Adult partial-onset seizures — 11-week titration to 200 mg once daily

Seizures — children ≤10 y or 30 kg: start 0.01–0.03 mg/kg/day

Seizures — adults: start ≤1.5 mg/day in 3 doses

Complex partial seizures — ≥10 y: start 10–15 mg/kg/day

Focal seizures, adults — maintenance 800–1600 mg once daily (start 400 mg)

Focal seizures, children 4–17 y — once-daily maintenance by weight (lower end of range)

Severe refractory epilepsy, adults and ≥14 y — start 1200 mg/day in 3 doses; up to 3600 mg/day

Partial seizures — ≥12 y: 300 mg three times daily

Partial seizures — 3–11 y: start 10–15 mg/kg/day in 3 doses

Partial-onset seizures (adjunctive) — adults and children ≥50 kg: start 50 mg twice daily

Partial-onset seizures — child 11 to <50 kg: start 1 mg/kg twice daily

Epilepsy — adults and children

Partial seizures — ≥16 y: 500 mg twice daily

Partial seizures — 1–6 months: 7 mg/kg twice daily (target 21)

Partial seizures — 6 months–4 y: 10 mg/kg twice daily (target 25)

Partial seizures — 4–15 y: 10 mg/kg twice daily (target 30)

Partial seizures — adults: start 600 mg/day in two doses

Partial seizures — 4–16 y: start 8–10 mg/kg/day in two doses

Partial-onset seizures (≥4 y) — 2 mg at bedtime, +2 mg weekly; maintenance 8–12 mg

Epilepsy (except absence) — adult: 60–200 mg/day in 2–3 doses

Epilepsy — child: start 3–6 mg/kg/day in 2–3 doses

Epilepsy — adults: 100 mg three times daily

Epilepsy — children: 5 mg/kg/day in 2 or 3 doses

Partial seizures (adjunct) — ≥17 y: start 150 mg/day

Partial seizures (adjunct) — child ≥30 kg: start 2.5 mg/kg/day

Partial seizures (adjunct) — child <30 kg: start 3.5 mg/kg/day

Epilepsy (tonic-clonic, psychomotor, focal) — ≥8 y: maintenance 250 mg three times daily

Children under 8 y — maintenance 125–250 mg three times daily

Epilepsy monotherapy — ≥10 y: target 400 mg/day in two doses

Complex partial seizures — ≥10 y: start 10–15 mg/kg/day

Absence seizures — start 15 mg/kg/day

Refractory complex partial seizures, adult (≥17 y) — 500 mg twice daily, +500 mg/day weekly to 1500 mg twice daily

Partial seizures (adjunct, >16 y) — 100 mg daily, +100 mg every 2 weeks up to 400 mg