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Valproic acid (oral solution)

والپروئیک اسید (شربت)

⚠ Unverified

🧠 Nervous SystemAnticonvulsant

🤰 Pregnancy:Contraindicated🤱 Breastfeeding:Use with caution👶 Children:Dangerous / avoid👴 Older adults:Use with caution⚥ Females & males of reproductive potential:Use with caution 🇮🇷 Registered in Iran⛔ 3 contraindications 🇺🇸 FDA approved generic (ANDA) ANDA075379ATC N03AG01

Market / country: 🇺🇸 USA

Depakene (US)

🧮 Dose calculator

Epilepsy (complex partial / absence seizures) · Regimen source: FDA Valproic acid sol. · 2.1

  • • Increase by 5–10 mg/kg/week; usual response below 60 mg/kg/day; levels 50–100 mcg/mL. Divide if >250 mg/day. FDA Valproic acid sol. · 2.1

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🛡️ Safety & information

Contraindications

Formulations

👥 Special populations

  • 🤰 PregnancyContraindicated

    Label: contraindicated in pregnancy. FDA Valproic acid sol. · 4

    “For use in prophylaxis of migraine headaches: Valproic acid is contraindicated in women who are pregnant and in women of childbearing potential who are not using effective contraception [see Warnings and Precautions (5.2 , 5.3 , 5.4) and Use in Specific Populations (8.1) ] .”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Valproic acid sol. · 8.2

    “Risk Summary Valproate is excreted in human milk.”
  • 👶 ChildrenDangerous / avoid

    Boxed warning in the label about children. FDA Valproic acid sol. · Boxed Warning

    “Children under the age of two years and patients with mitochondrial disorders are at higher risk.”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Valproic acid sol. · 8.5

    “A study of elderly patients with dementia revealed drug related somnolence and discontinuation for somnolence [see Warnings and Precautions (5.14) ] .”
  • ⚥ Females & males of reproductive potentialUse with caution

    Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Valproic acid sol. · 8.3

    “Contraception Women of childbearing potential should use effective contraception while taking valproate [see Boxed Warning , Warnings and Precautions (5.4) , Drug Interactions (7) , and Use in Specific Populations (8.1) ] .”

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