Heart failure

Heart failure (adjunct to a diuretic) — 5 mg daily, up to 10 mg

Heart failure — start 3.125 mg twice daily for 2 weeks

Under 18 years

Heart failure / CKD — 10 mg once daily

Heart failure / AF rate control

Heart failure / CKD — adults: 10 mg

Heart failure — adults: start 2.5 mg

HF after MI — start 25 mg once daily, up to 50 mg within 4 weeks

Heart failure with LVEF ≥40% — start 10 or 20 mg, target 20 or 40 mg

Adult heart failure — start 5 mg twice daily with food

Child ≥6 months, <40 kg — start 0.05 mg/kg twice daily (solution)

Child ≥40 kg — start 2.5 mg twice daily

Heart failure — start 5 mg once daily

Acute decompensated heart failure — loading 50 mcg/kg slowly over 10 min

Maintenance — 0.375–0.75 mcg/kg/min (standard 0.5)

Heart failure after MI — 2.5 mg twice daily

Adult heart failure — start 49/51 mg twice daily, target 97/103 mg

Child ≥1 y, <40 kg — start 1.6 mg/kg twice daily (combined)

Child ≥40 kg — starting dose by weight, twice daily

Heart failure — 25 mg once daily

Under 18 years

Heart failure — adults: start 40 mg twice daily

HFrEF (EF <45%) after worsening — start 5 mg, double every 2 weeks to 10 mg